Monitoring progress of maternal and neonatal immunization in Latin America and the Caribbean

Velandia-González, Martha; Vilajeliu, Alba; Contreras, Marcela; Trumbo, Silas P.; Pacis, Carilu; Ropero, Alba María; Ruiz-Matus, Cuauhtémoc

doi:10.1016/j.vaccine.2020.12.043

Cited by 14 publications

(27 citation statements)

References 9 publications

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“…Nevertheless, vaccination of older pregnant women (35–49 years of age), black or Hispanic, with low educational level, single, unemployed, below the poverty line, residents in non-rural areas, without prenatal insurance was lower in public health insurance [ 4 ]. In Latin America and the Caribbean, until 2018, 14 of 49 countries and territories had recommended vaccination of pregnant women with Tdap in their routine vaccination programs and between 2012 and 2018, 12 countries had reported oscillating vaccination coverage [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…In Latin America and the Caribbean, seroprevalence studies have been conducted on the effect of vaccinating against pertussis [ 6 7 8 ], but as far as we know, immunity conferred against diphtheria and tetanus and the variables that could influence on sero-protection for these diseases has not been studied. Sero-surveillance of diphtheria and tetanus in pregnant women and neonates is especially useful in this region, given the difficulty of having a vaccination card, up-to-data information from population census, and state pregnancy records in the vaccination information system [ 5 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Successful seroconversion against diphtheria and tetanus induced through maternal vaccination in a region of Colombia

Hincapié-Palacio

Echeverri

Hoyos

et al. 2022

Clin Exp Vaccine Res

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Purpose This study aims to compare protection against diphtheria and tetanus conferred on the mother and the neonate before and after maternal vaccination against tetanus, diphtheria, and acellular pertussis (Tdap), transfer of antibodies, and the variables that could impact on the protection. Materials and Methods The study followed a cohort of 200 pregnant women from a region in Colombia, contacted during prenatal control before vaccination and upon delivery. The work determined immunoglobulin G antibodies against diphtheria and tetanus of pregnant women and umbilical cord. The proportion of protection, the geometric mean of the concentration, and the transfer of maternal antibodies were calculated. The protection profile of the pregnant women was explored by using multiple correspondence analysis. Results The concentration of antibodies against diphtheria was significant before and after vaccination of the pregnant women (p=0.000) with proportions of 85.0% and 97.5%, respectively, and of 98.6% in the umbilical cord, with significant antibody correlation (Spearman’s coefficient=0.668, p=0.01). Sero-protection against tetanus before vaccination was at 71.0%, after at 92.6%, and in the umbilical cord at 95.9%, with significant antibody concentration before and after vaccination (p=0.000) and antibody correlation (Spearman’s coefficient=0.936, p=0.01). Sero-protection was higher when the pregnant women were vaccine 8 to 11 weeks before delivery. Unprotected pregnant women were those not vaccinated during pregnancy. Conclusion The high proportion of protection against diphtheria and tetanus and the placental transfer support the need to promote maternal immunization with Tdap.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Successful seroconversion against diphtheria and tetanus induced through maternal vaccination in a region of Colombia

Hincapié-Palacio

Echeverri

Hoyos

et al. 2022

Clin Exp Vaccine Res

View full text Add to dashboard Cite

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“…Current vaccination coverage rates in Latin America and the Caribbean fall short of the targets set by the Pan American Health Organization, with coverage varying both between and within countries [3,4]. Coverage rates for vaccines recommended during pregnancy tend to fluctuate over time [5]. In Mexico, for example, influenza vaccination rates for pregnant women fell from 81% in 2018 [5] to 65% in 2020 [6]; while Tdap coverage for pregnant women jumped from 52% in 2015 to 96% in 2016 before dropping again to 60% in 2018.…”

Section: Introductionmentioning

confidence: 99%

“…Coverage rates for vaccines recommended during pregnancy tend to fluctuate over time [5]. In Mexico, for example, influenza vaccination rates for pregnant women fell from 81% in 2018 [5] to 65% in 2020 [6]; while Tdap coverage for pregnant women jumped from 52% in 2015 to 96% in 2016 before dropping again to 60% in 2018. Despite inadequate coverage rates, a recent systematic review of barriers to vaccination in Latin America [7], found very few studies which have looked at barriers to vaccination among pregnant women in the region [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“Saint Google, now we have information!”: a qualitative study on narratives of trust and attitudes towards maternal vaccination in Mexico City and Toluca

2021

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Background Maternal vaccination is key to decreasing maternal and infant mortality globally. Yet perceptions about maternal vaccines and immunization among pregnant women are often understudied, particularly in low- and middle- income countries. This qualitative study explored trust, views, and attitudes towards maternal immunization among pregnant women in Mexico. A total of 54 women from Mexico City and Toluca participated in the in-depth interviews and focus groups. We explored participants’ experiences with maternal vaccination, as well as how they navigated the health system, searched for information, and made decisions around maternal immunization. Results Our findings point to issues around access and quality of maternal healthcare, including immunizations services. While healthcare professionals were recognized for their expertise, participants reported not receiving enough information to make informed decisions and used online search engines and digital media to obtain more information about maternal healthcare. Some participants held strong doubts over the benefits of vaccination and were hesitant about the safety and efficacy of maternal vaccines. These concerns were also shared by pregnant women who had been vaccinated. Some participants disclosed low levels of trust in government and vaccination campaigns. Conclusion Pregnant women, soon to be parents and making vaccination decisions for their child, constitute an important target group for policymakers seeking optimal maternal as well as childhood immunization coverage. Our findings highlight the importance of targeted communication, trust-building and engagement strategies to strengthen confidence in immunization amongst this group.

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“…Interventions launched under this strategic plan sought to fulfill the mission of the Decade of Vaccines (2011–2020): “to extend, by 2020 and beyond, the full benefit of immunization to all people, regardless of where they are born, who they are or where they live” [12] . Velandia-González et al recapped the progress made toward the plan’s targets relevant to maternal neonatal immunization, and proposed coordinated practices for vaccination data accrual, integration of health programs, and technical innovation [13] .…”

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confidence: 99%

Maternal and neonatal immunization in the Americas: The benefits, the hurdles, and the way forward

Pasetti

Healy

2021

Vaccine

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Monitoring progress of maternal and neonatal immunization in Latin America and the Caribbean

Cited by 14 publications

References 9 publications

Successful seroconversion against diphtheria and tetanus induced through maternal vaccination in a region of Colombia

Successful seroconversion against diphtheria and tetanus induced through maternal vaccination in a region of Colombia

“Saint Google, now we have information!”: a qualitative study on narratives of trust and attitudes towards maternal vaccination in Mexico City and Toluca

Maternal and neonatal immunization in the Americas: The benefits, the hurdles, and the way forward

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