Monitoring Physiological Changes in Neutron-Exposed Normal Mouse Brain Using FDG-PET and DW-MRI

Kang, Kyung Jun; Jung, Kim Mi; Choi, Eunji; Kim, Hyosung; Hee, Sun; Ko, In Ok; Oh, Se Jong; Lee, Yong Jin; Kim, Jung Young; Park, Ji Ae

doi:10.1667/rr15405.1

Cited by 1 publication

(1 citation statement)

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“…For example, in our study, the temporal lobe in pat.6 was hypermetabolic and initially diagnosed in <1 month, but pat.3 already had a hypometabolic temporal lobe in the chronic stages when he was hospitalized. Additionally, PET can play a role in the early initiation of corticosteroid treatment that is effective for damage to the blood–brain barrier, 40 especially when preliminary laboratory results and MRI are not initially positive. For instance, in this study the serum results of pat.7 were negative and MRI was ambiguous, but at the same stage, PET was obviously abnormal.…”

Section: Discussionmentioning

confidence: 99%

Hypometabolism of the left middle/medial frontal lobe onFDG‐PETin anti–NMDAreceptor encephalitis: Comparison withMRIandEEGfindings

et al. 2023

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Objectives To investigate changes in brain‐glucose metabolism in anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis, and compare results with MRI and electroencephalography (EEG) findings at different disease stages. Methods The clinical data of 18 patients (median age, 35 years; 11 men) were retrospectively collected. Patients were divided into groups based on the time of symptom onset to examination, (≤1 month, >1 but ≤3 months, >3 months). Two‐sample t ‐test results were compared with age and sex‐paired healthy controls using statistical parametric mapping and verified using a NeuroQ software normal database with a discriminating z‐score of 2. Results Abnormal patterns on FDG‐PET differed over time ( T = 3.21–8.74, Z = 2.68–4.23, p < 0.005). Regional analysis showed hypometabolic left middle or medial frontal cortex in 4/5, 5/7, and 5/6 patients, respectively. Time‐subgroup analysis revealed hypermetabolic supertemporal cortex in 4/5, 5/7, and 2/6, patients, respectively. MRI and EEG abnormalities in any region and stage occurred in 10/18 and 10/16 patients, respectively. MRI and EEG time‐subgroup analysis showed abnormalities in 5/9, 4/5, and 1/4, and 1/3, 6/7, and 3/6 patients, respectively. Abnormal temporal lobes were detected most frequently in MRI analyses and occurred in 3/10 patients. Conclusions Decreased left middle/medial frontal metabolism could be common to all stages. Metabolism in other regions, MRI, and EEG results were associated with the progression of anti‐NMDAR encephalitis. The sensitivity rate of FDG‐PET was superior to that of MRI and EEG.

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Section: Discussionmentioning

confidence: 99%