Monitoring Overeruption Pattern of Young vs Adult Unopposed Molars in the Rat

Denes, Balazs Jozsef; Lagou, Aikaterini; Kiliaridis, Stavros

doi:10.11607/ijp.6644

Cited by 4 publications

(2 citation statements)

References 3 publications

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“…27 And it's noteworthy that molars in adult patients had a lower risk of overeruption, 27 in agreement with the conclusion that hypofunctional molars from young rats supraerupt more than those from adult rats. 28,29 Thus, anticipating to obtain more marked phenotypic changes between the CG and HG, we carried out an in vivo study in a 4-week-old young mice, which may account for the remaining growth potential of alveolar bone in the CG.…”

Section: Discussionmentioning

confidence: 99%

Periodontal ligament‐associated protein‐1 engages in teeth overeruption and periodontal fiber disorder following occlusal hypofunction

Chen

Luo

Xie

et al. 2022

J of Periodontal Research

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Background and Objective: Teeth overeruption is a problem of clinical significance, but the underlying mechanism how changes in external occlusal force convert to the periodontium remodeling signals has been a largely under explored domain. And recently, periodontal ligament-associated protein-1 (PLAP-1)/asporin was found to play a pivotal role in maintaining periodontal homeostasis. The aim of this study was to explore the function of PLAP-1 in the periodontally hypofunctional tissue turnover. Methods:After extracting left maxillary molars in mice, the left and right mandibular molars were distributed into hypofunction group (HG) and control group (CG), respectively. Mice were sacrificed for radiographic, histological, and molecular biological analyses after 1, 4 and 12 weeks. In vitro, dynamic compression was applied using Flexcell FX-5000 Compression System to simulate intermittent occlusal force. The expression of PLAP1 in loaded and unloaded human periodontal ligament cells (hP-DLCs) was compared, and its molecular biological effects were further explored by small interfering RNA (siRNA) targeting PLAP1. Results:In vivo, fiber disorder in periodontal ligament (PDL), bone apposition at furcation regions, and bone resorption in alveolar bone were illustrated in the HG compared with the CG. In addition, PLAP-1 positive area decreased significantly in PDL following occlusal unloading. In vitro, the loss of compressive loading relatively downregulated PLAP1 expression, which was essential to promote collagen I but inhibit osterix and osteocalcin expression in hPDLCs.Conclusions: PLAP-1 presumably plays a pivotal role in occlusal force-regulated periodontal homeostasis by facilitating collagen fiber synthesis in hPDLCs and suppressing excessive osteoblast differentiation, further preventing teeth from overeruption.

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Section: Discussionmentioning

confidence: 99%

Periodontal ligament‐associated protein‐1 engages in teeth overeruption and periodontal fiber disorder following occlusal hypofunction

Chen

Luo

Xie

et al. 2022

J of Periodontal Research

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show abstract

“…An average overeruption of 0.8–0.9 mm was found after a ten-year follow-up. Several factors were reported associated with the spatial changes of overeruption of tooth, such as the age when the antagonist teeth were lost, arch location, and severity/duration of periodontal disease [ 7 , 8 , 11 , 14 , 18 , 20 ]. Nevertheless, the overeruption of a molar is potentially a complicated spatial movement, involving not only vertical migration, but also tipping and rotation [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional position changes of unopposed molars before implant rehabilitation: a short-term retrospective cohort analysis

et al. 2022

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Objective To investigate the spatial changes of unopposed molars within the period between the antagonist extraction and the final implant restoration using data from cone beam computed tomography. Methods A total of 59 patients with 68 unopposed molars were included in this study. Three-dimensional models reconstructed from cone beam computed tomography data before and after loss of the antagonist were superimposed to measure the spatial changes. The overeruption and tipping of target teeth were calculated by coordinate values. Results The result of overeruption over the study period (9.2 ± 4.3 months) was expressed by two values: the mean overeruption of molar cups (0.432 mm) and the maximum overeruption of cusps (0.753 mm), which were statistically significant compared to the baseline level (p < 0.001). The average tipping was 1.717 degrees in the buccal direction. Conclusions Unopposed molars displayed overeruption throughout the study period (9.2 ± 4.3 months), which indicates that the clinicians should pay attention to the possibilities of overeruption and make appropriate interventions in their clinical practice. The establishment of three-dimensional measuring methods using cone beam computed tomography data helps analyze spatial changes.

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Innovative device for in-vivo quantitative assessment of different wire materials using 3D models

Adly,

Adly

et al. 2024

Journal of Science: Advanced Materials and Devices

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Monitoring Overeruption Pattern of Young vs Adult Unopposed Molars in the Rat

Cited by 4 publications

References 3 publications

Periodontal ligament‐associated protein‐1 engages in teeth overeruption and periodontal fiber disorder following occlusal hypofunction

Periodontal ligament‐associated protein‐1 engages in teeth overeruption and periodontal fiber disorder following occlusal hypofunction

Three-dimensional position changes of unopposed molars before implant rehabilitation: a short-term retrospective cohort analysis

Innovative device for in-vivo quantitative assessment of different wire materials using 3D models

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