Monitoring of the Intracranial Hemodynamics and Oxygenation during and after Hyperventilation in Newborn Rabbits with Near-Infrared Spectroscopy

Kamei, Atsushi; Ozaki, Takeo; Takashima, Sachio

doi:10.1203/00006450-199403000-00012

Cited by 29 publications

(4 citation statements)

References 18 publications

(20 reference statements)

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“…The effects of hyperventilation demonstrated by NIRS have been reported in Kamei's paper including decreases in oxyhemoglobin and total hemoglobin and an increase in deoxyhemoglobin during hyperventilation. 28) Regardless, the elevated deoxyhemoglobin originates either from a hypoxic condition that leads to proton accumulation and further hyperventilation or from exertional hyperventilation to reduce PaCO 2 , which further induces vasoconstriction and deteriorated hypoxic levels during exercise. 25) As a result, impaired coordination in ventilatory/hemodynamic adaptation to exercise was evident.…”

Section: Discussionmentioning

confidence: 99%

Central and Peripheral Hemodynamic Adaptations During Cardiopulmonary Exercise Test in Heart Failure Patients With Exercise Periodic Breathing

Chou

Chen

et al. 2015

Int. Heart J.

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Some heart failure (HF) patients develop ventilatory oscillation which is composed of exercise periodic breathing (EPB) and sleep apnea. The ventilatory oscillation is associated with exercise intolerance. This study employed an integrated monitoring system to elucidate the way of central and peripheral hemodynamic adaption responding to exercise. This study recruited 157 HF patients to perform exercise testing using a bicycle ergometer. A noninvasive bio-reactance device was adopted to measure cardiac hemodynamics, whereas a near-infrared spectroscopy (NIRS) was used to assess perfusion and O2 extraction in the frontal cerebral lobe (FC) and vastus lateralis muscle (VL) during exercise respectively. Furthermore, quality of life (QoL) was measured with the Short Form-36 (SF-36) and the Minnesota Living with Heart Failure questionnaires (MLHFQ). The patients were divided into an EPB group (n = 65) and a non-EPB group (n = 92) according to their ventilation patterns during testing. Compared to their non-EPB counterparts, the patients with EPB exhibited 1) impaired aerobic capacity with a smaller peak oxygen consumption (VO2peak) and oxygen uptake efficiency slopes; 2) impaired circulatory and ventilatory efficiency with relatively high cardiac output and ventilation per unit workload; 3) impaired ventilatory/hemodynamic adaptation in response to exercise with elevated deoxyhemoglobin levels in the FC region; and 4) impaired QoL with lower physical component scores on the SF-36 and higher scores on the MLHFQ. In conclusion, EPB may reduce circulatory-ventilatory-hemodynamic efficiency during exercise, thereby impairing functional capacity in patients with HF.

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Section: Discussionmentioning

confidence: 99%

Central and Peripheral Hemodynamic Adaptations During Cardiopulmonary Exercise Test in Heart Failure Patients With Exercise Periodic Breathing

Chou

Chen

et al. 2015

Int. Heart J.

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“…PaCO 2 is well known to influence cerebral vascular tone and thus cerebral blood volume. Hyperventilation and a subsequent reduction in PaCO 2 has been shown to reduce cerebral oxygenation [29]. In addition, PaCO 2 is known to affect the Hb-oxygen saturation curve.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Oxygenation Is Affected by Filling Mode and Perfluorochemical Volume in Partial Liquid Ventilation of Healthy Piglets

Burkhardt

Proquitté²,

Krause³

et al. 2002

Neonatology

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Intrapulmonary administration of perfluorochemicals (PFC) has been suggested for reasons other than respiratory insufficiency. PFC application has been described to affect cerebral Hb concentration, however, data for healthy lungs are missing. Newborn piglets were randomized into 3 groups (30-ml slow-filling, 10-ml slow-filling and 30-ml rapid-filling), orally intubated and mechanically ventilated. Partial liquid ventilation (PLV) was initiated by filling the lung with PF5080 (10 or 30 ml/kg) at a rate of 1.5 ml/min (slow filling) or within 45 s (rapid filling). Vital signs, blood gases, tidal volume (VT) and changes in the cerebral concentration of oxygenated hemoglobin (HbO₂) and total Hb were determined for up to 20 min. Rapid administration of PFC caused an immediate drop in HbO₂, PaO₂ and VT. The concentration of oxygenated and total Hb increased thereafter and remained high. We found a slow increase in PaCO₂, HbO₂ and total Hb in the 30-ml slow-filling group, but almost no changes in the 10-ml slow filling group (except for a decrease in PaO₂). According to our data, PLV with 10 ml/kg should be preferred since cerebral alterations are minimal. If complete filling of the lung is needed PFC should be administered slowly to minimize side effects.

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“…Local brain activity was quantified for the first time in 1993 using continuouswave fNIRS, by substituting optical differential path length factors [8]. At that time, mmol•mm (or mmol•cm) was commonly used as the unit expressing the degree of change in the levels of Hb, taking the differential path length factor as 1 [111,112]. The phase angle k expresses oxygen metabolism quantitatively in degrees.…”

Section: Quantification Of Brain Activity In Time Seriesmentioning

confidence: 99%

Vector-Based Approach for the Detection of Initial Dips Using Functional Near-Infrared Spectroscopy

Kato¹

2019

Neuroimaging - Structure, Function and Mind

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Functional near-infrared spectroscopy (fNIRS) is a non-invasive method for the detection of local brain activity using changes in the local levels of oxyhemoglobin (oxyHb) and deoxyhemoglobin (deoxyHb). Simultaneous measurement of the levels of oxyHb and deoxyHb is an advantage of fNIRS over other modalities. This review provides a historical description of the physiological problems involved in the accurate identification of local brain activity using fNIRS. The need for improved spatial and temporal identification of local brain activity is described in terms of the physiological challenges of task selection and placement of probes. In addition, this review discusses challenges with data analysis based on a single index, advantages of the simultaneous analysis of multiple indicators, and recently established composite indicators. The vector-based approach provides quantitative imaging of the phase and intensity contrast for oxygen exchange responses in a time series and may detect initial dips related to neuronal activity in the skull. The vector plane model consists of orthogonal vectors of oxyHb and deoxyHb. Initial dips are hemodynamic reactions of oxyHb and deoxyHb induced by increased oxygen consumption in the early tasks of approximately 2-3 seconds. The new analytical concept of fNIRS, able to effectively detect initial dips, may extend further the clinical and social applications of fNIRS.

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Monitoring of the Intracranial Hemodynamics and Oxygenation during and after Hyperventilation in Newborn Rabbits with Near-Infrared Spectroscopy

Cited by 29 publications

References 18 publications

Central and Peripheral Hemodynamic Adaptations During Cardiopulmonary Exercise Test in Heart Failure Patients With Exercise Periodic Breathing

Central and Peripheral Hemodynamic Adaptations During Cardiopulmonary Exercise Test in Heart Failure Patients With Exercise Periodic Breathing

Cerebral Oxygenation Is Affected by Filling Mode and Perfluorochemical Volume in Partial Liquid Ventilation of Healthy Piglets

Vector-Based Approach for the Detection of Initial Dips Using Functional Near-Infrared Spectroscopy

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