Monitoring of the central blood pressure waveform via a conformal ultrasonic device

Wang, Chonghe; Li, Xiaoshi; Hu, Hongjie; Zhang, Lin; Huang, Zhenlong; Lin, Muyang; Zhang, Zhuorui; Yin, Zhenan; Huang, Brady K.; Gong, H.; Bhaskaran, Shubha; Gu, Yue; Makihata, Mitsutoshi; Guo, Yuxuan; Lei, Yusheng; Chen, Yimu; Wang, Chunfeng; Li, Yang; Zhang, Tianjiao; Chen, Zeyu; Pisano, Albert P.; Zhang, Liangfang; Zhou, Qifa; Xu, Sheng

doi:10.1038/s41551-018-0287-x

Cited by 546 publications

(474 citation statements)

References 50 publications

Supporting

Mentioning

467

Contrasting

Unclassified

Order By: Relevance

“…Apart from the PTT-based BP estimation method, some other physiological features have been investigated to indicate BP changes, including PPG intensity ratio [109], Womersley number [110], radial electrical bioimpedance [111], modified normalized pulse volume [112], acceleration plethysmography (APG) [113], and diameter of a pulsating blood vessel [114]. Additionally, machine learning has also been applied to BP estimation to develop regression models between signal features and BP, and demonstrating promising estimation accuracy [115][116][117][118][119][120].…”

Section: B Continuous Blood Pressure Monitoringmentioning

confidence: 99%

See 1 more Smart Citation

Wearable Sensing and Telehealth Technology with Potential Applications in the Coronavirus Pandemic

Ding

Clifton

et al. 2021

IEEE Rev. Biomed. Eng.

189

135

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) has emerged as a pandemic with serious clinical manifestations including death.A pandemic at the large-scale like COVID-19 places extraordinary demands on the world's health systems, dramatically devastates vulnerable populations, and critically threatens the global communities in an unprecedented way. While tremendous efforts at the frontline are placed on detecting the virus, providing treatments and developing vaccines, it is also critically important to examine the technologies and systems for tackling disease emergence, arresting its spread and especially the strategy for diseases prevention. The objective of this article is to review enabling technologies and systems with various application scenarios for handling the COVID-19 crisis. The article will focus specifically on 1) wearable devices suitable for monitoring the populations at risk and those in quarantine, both for evaluating the health status of caregivers and management personnel, and for facilitating triage processes for admission to hospitals; 2) unobtrusive sensing systems for detecting the disease and for monitoring patients with relatively mild symptoms whose clinical situation could suddenly worsen in improvised hospitals; and 3) telehealth technologies for the remote monitoring and diagnosis of COVID-19 and related diseases. Finally, further challenges and opportunities for future directions of development are highlighted.

show abstract

Section: B Continuous Blood Pressure Monitoringmentioning

confidence: 99%

“…Cuffless continuous monitoring approaches can be implemented into wearable and unobtrusive devices, such as watch [121], glasses [122,123], a wrist/armband [99,124,125], shirt [126], sleeping cushion [127], chair [128], smartphone [112], camera and flexible patch [114,129,130] as summarized in Fig. 8.…”

Section: B Continuous Blood Pressure Monitoringmentioning

confidence: 99%

Wearable Sensing and Telehealth Technology with Potential Applications in the Coronavirus Pandemic

Ding

Clifton

et al. 2021

IEEE Rev. Biomed. Eng.

189

135

View full text Add to dashboard Cite

show abstract

“…ultrasound devices, molecular thermo-sensors, and genetic/epigenetic transducing modules, is highly modular and will continue to evolve for greater precision and reduced immunogenicity. In fact, stretchable electronic circuits are being developed to fabricate wearable patches of ultrasound transducers ( 34 ). The leverage of technological advancements of different fields into FUS-based acoustogenetics should be able to drive the development of these fields to open up new frontiers.…”

Section: Discussionmentioning

confidence: 99%

Acoustogenetic Control of CAR T Cells via Focused Ultrasound

Wu¹,

Huang³

et al. 2020

Preprint

View full text Add to dashboard Cite

14Optogenetics can control specific molecular events in living systems, but the penetration depth of 15 light is typically limited at hundreds of micrometers. Focused ultrasound (FUS), on the other 16 hand, can deliver energy safely and noninvasively into tissues at depths of centimeters. Here we 17 have developed an acoustogenetic approach using short-pulsed FUS to remotely and directly 18 control the genetics and cellular functions of engineered mammalian cells for therapeutic 19 purposes. We applied this acoustogenetic approach to control chimeric antigen receptor (CAR) T 20 cells with high spatiotemporal precision, aiming to mitigate the potentially lethal "on-target off-21 tumor" effects of CAR T cell therapy. We first verified the controllability of our acoustogenetic 22 CAR T cells in recognizing and killing tumor cells in vitro, and then applied this approach in 23 vivo to suppress tumor growth of both lymphoma and prostate cancers. The results indicate that 24 FUS-based acoustogenetics can allow the noninvasive and remote activation, without any 25 exogenous cofactor, of different types of CAR T cells for cancer therapeutics. 26Optogenetics enables the control of specific molecular events and cellular functions in living 27 systems with high spatiotemporal resolutions. However, optogenetics cannot reach deep tissues, 28 with the penetration depth of light typically limited at micrometer to millimeter scales (1). 29Ultrasound can be focused to deliver mechanical energy safely and noninvasively into small 30 volumes of tissue deep inside the body up to tens of centimeters (1). The rapidly oscillating 31 pressure of focused ultrasound (FUS) waves and the resultant cycles of mechanical 32 loading/unloading can lead to local heat generation in biological tissues. Aided by Magnetic 33Resonance Imaging (MRI) thermometry, FUS has been widely applied to clinically ablate 34 tumors, and control drug delivery, vasodilation, neuromodulation (2), and transgene expression 35(3-5). Transcription factors and genetic circuits have also been engineered to convert the FUS-36 generated heat into genetic regulation to control microbial systems in vivo (6). However, there is 37 a lack of general methods using FUS to control mammalian cell functions in vivo for therapeutic 38 applications. 40Chimeric antigen receptor (CAR) T cell therapy, where T cells are genetically programmed with 41 redirected specificity against malignant cells, is becoming a paradigm-shifting approach for 42 cancer treatment, especially for blood cancers (7). However, major challenges remain for solid 43 tumors before CAR-based immunotherapy can be widely adopted. For instance, the non-specific 44 targeting of the CAR T cells against normal tissues (on-target off-tumor toxicities) can be life-45 threatening: off-tumor toxicities against the lung, the brain, and the heart have caused multiple 46 cases of deaths (7-10). Immunosuppressive corticosteroid therapy and suicide gene engineering 47 are relatively effective in suppressing off-tumor tox...

show abstract

“…h) Conformal ultrasonic sensor for blood pressure measurement and typical pulse waveform at the carotid artery correlated to the left atrial and ventricular events. Reproduced with permission . Copyright 2018, Springer Nature.…”

Section: Stretchable and Conformal Sensors For Cyber Biophysical Intementioning

confidence: 99%

“…Enhancing interfacial adhesion eventually contributes to the stable collection of weak epidermal biomechanical signals. Applying conformability to an ultrasonic device allows the capture of blood pressure waveforms with long‐term stability at embedded arterial and venous sites with depth of ≈4 cm . These signals contain important diagnostic information such as deep‐lying internal jugular venous pulses which are helpful for real‐time monitoring of the user's state of health (Figure h) …”

Section: Stretchable and Conformal Sensors For Cyber Biophysical Intementioning

confidence: 99%

Cyber–Physiochemical Interfaces

et al. 2020

View full text Add to dashboard Cite

Living things rely on various physical, chemical, and biological interfaces, e.g., somatosensation, olfactory/gustatory perception, and nervous system response. They help organisms to perceive the world, adapt to their surroundings, and maintain internal and external balance. Interfacial information exchanges are complicated but efficient, delicate but precise, and multimodal but unisonous, which has driven researchers to study the science of such interfaces and develop techniques with potential applications in health monitoring, smart robotics, future wearable devices, and cyber physical/human systems. To understand better the issues in these interfaces, a cyber–physiochemical interface (CPI) that is capable of extracting biophysical and biochemical signals, and closely relating them to electronic, communication, and computing technology, to provide the core for aforementioned applications, is proposed. The scientific and technical progress in CPI is summarized, and the challenges to and strategies for building stable interfaces, including materials, sensor development, system integration, and data processing techniques are discussed. It is hoped that this will result in an unprecedented multi‐disciplinary network of scientific collaboration in CPI to explore much uncharted territory for progress, providing technical inspiration—to the development of the next‐generation personal healthcare technology, smart sports‐technology, adaptive prosthetics and augmentation of human capability, etc.

show abstract

Monitoring of the central blood pressure waveform via a conformal ultrasonic device

Cited by 546 publications

References 50 publications

Wearable Sensing and Telehealth Technology with Potential Applications in the Coronavirus Pandemic

Wearable Sensing and Telehealth Technology with Potential Applications in the Coronavirus Pandemic

Acoustogenetic Control of CAR T Cells via Focused Ultrasound

Cyber–Physiochemical Interfaces

Contact Info

Product

Resources

About