Monitoring of systemic candidiasis by 18F-FDG PET/CT

Avet, John; Granjon, D.; Prévôt-Bitot, Nathalie; Isnardi, V.; Berger, Claire; Stéphan, Jean Louis; Dubois, Francis

doi:10.1007/s00259-009-1255-1

Cited by 14 publications

(27 citation statements)

References 3 publications

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“…The available publications demonstrate the usefulness of FDG in monitoring both the more common causes of IFIs, Candida and Aspergillus sp. [82][83][84][85][86][87][88], and also the other causes of IFIs such as Zygomycosis sp. [84,[90][91][92], Histoplasmosis sp [94,95], Coccidimycosis, Phomopsis, Mycetomas spp.…”

Section: Monitoring Ifis With Fdg Petmentioning

confidence: 99%

“…Again although underrepresented, the literature shows monitoring therapy is effective in children just as well as in adults [82,83,85,87]. High resolution CT scan was found to have an impact on the early diagnosis of IFIs, especially in Aspergillus, resulting in including this technique in the guidelines.…”

Section: Monitoring Ifis With Fdg Petmentioning

confidence: 99%

“…FDG imaging led to a change in antifungal therapy because of the poor response seen on follow up FDG studies in a number of reports [86,87,89]. It also helped to extend antifungal therapy in a case in which response was seen but in which there was still some disease activity after 120 days.…”

Section: Monitoring Ifis With Fdg Petmentioning

confidence: 99%

“…In another study, FDG was unfortunately not performed before starting the therapy but when the scan was performed during therapy, it not only showed poor response to the antifungal treatment but it also revealed other foci of infection that were previously unknown to the clinicians [87].…”

Section: Monitoring Ifis With Fdg Petmentioning

confidence: 99%

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The Role of PET in Monitoring Therapy in Fungal Infections

Ankrah

Klein

Span

et al. 2018

CPD

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Positron emission tomography (PET) is a powerful diagnostic nuclear medicine imaging technique. PET allows in vivo detection of a wide variety of physiologic and pathologic phenomena and it offers a noninvasive tool for the monitoring of therapy in various diseases. Invasive fungal infections (IFIs) are a global concern because of the increasing population of patients at risk of IFIs and the high morbidity and mortality. Therapy with antifungal agents is long-standing and expensive. The emerging resistant fungal strains make the management of IFIs challenging. There is an absolute need for a sensitive noninvasive biomarker capable of monitoring the disease activity of IFIs and determining the efficacy of treatment at an early time point. PET imaging with 18F-fluorodeoxyglucose (FDG) was used to detect and assess disease activity in IFI foci already over 20 years ago. At that time, it was suggested it could be a useful biomarker for monitoring antifungal therapy. However, this knowledge has still not been fully exploited for the management of IFIs. The literature reveals an increasing realization of the usefulness of PET in monitoring therapy of IFIs. In this review, we highlight the advantages of nuclear medicine techniques in the management of IFIs with emphasis of the role of PET in monitoring therapy efficacy.

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Section: Monitoring Ifis With Fdg Petmentioning

confidence: 99%

Section: Monitoring Ifis With Fdg Petmentioning

confidence: 99%

Section: Monitoring Ifis With Fdg Petmentioning

confidence: 99%

Section: Monitoring Ifis With Fdg Petmentioning

confidence: 99%

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The Role of PET in Monitoring Therapy in Fungal Infections

Ankrah

Klein

Span

et al. 2018

CPD

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“…In general, image data can be obtained by different experimental approaches, e.g., microscopy, positron emission tomography (PET)/computer tomography (CT), or bioluminescence imaging. Due to the fact that the latter two techniques for monitoring fungal infections in living hosts are still in the early stages of development (Avet et al, 2009; Ibrahim-Granet et al, 2010), we focus here on recent studies using microscopy-generated image data. A good example of such data is represented by monitoring the interaction of labeled fungal cells, i.e., conidia, germlings, or hyphae, with immune effector cells using microscopy, especially fluorescence microscopy or confocal laser scanning microscopy (CLSM).…”

Section: Data Basis and Data Analysismentioning

confidence: 99%

Systems Biology of Fungal Infection

Horn¹,

Heinekamp²,

Kniemeyer³

et al. 2012

Front. Microbio.

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Elucidation of pathogenicity mechanisms of the most important human-pathogenic fungi, Aspergillus fumigatus and Candida albicans, has gained great interest in the light of the steadily increasing number of cases of invasive fungal infections. A key feature of these infections is the interaction of the different fungal morphotypes with epithelial and immune effector cells in the human host. Because of the high level of complexity, it is necessary to describe and understand invasive fungal infection by taking a systems biological approach, i.e., by a comprehensive quantitative analysis of the non-linear and selective interactions of a large number of functionally diverse, and frequently multifunctional, sets of elements, e.g., genes, proteins, metabolites, which produce coherent and emergent behaviors in time and space. The recent advances in systems biology will now make it possible to uncover the structure and dynamics of molecular and cellular cause-effect relationships within these pathogenic interactions. We review current efforts to integrate omics and image-based data of host-pathogen interactions into network and spatio-temporal models. The modeling will help to elucidate pathogenicity mechanisms and to identify diagnostic biomarkers and potential drug targets for therapy and could thus pave the way for novel intervention strategies based on novel antifungal drugs and cell therapy.

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