Monitoring of pesticides in river water using fully automated on-line solid-pase extraction and liquid chromatography with diode array detection with a novel filtration device

Lacorte, Sı́lvia; Vreuls, J. J.; Salau, J.S.; Ventura, Francesc; Barceló, Damià

doi:10.1016/s0021-9673(97)00619-5

Cited by 44 publications

(20 citation statements)

References 14 publications

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“…The same principle as in traditional SPE is used in the on-line separation methods (Barcelo and Hennion, 1997;Lacorte et al, 1998;Morr et al, 2006;Kushnir et al, 2008). The on-line separation usually leads to a reduced complexity of the sample preparation, reduced labor, and improvement in the detection limits.…”

Section: B Sample Preparationmentioning

confidence: 99%

Liquid chromatography-tandem mass spectrometry applications in endocrinology

Kushnir

Rockwood

Bergquist

2009

Mass Spectrom. Rev.

138

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Liquid chromatography-tandem mass spectrometry (LC-MS/ MS) has been recognized as a primary methodology for the accurate analysis of endogenous steroid hormones in biological samples. This review focuses on the use of LC-MS/MS in clinical laboratories to assist with the diagnosis of diverse groups of endocrine and metabolic diseases. Described analytical methods use on-line and off-line sample preparation and analytical derivatization to enhance analytical sensitivity, specificity, and clinical utility. Advantages of LC-MS/MS as an analytical technique include high specificity, possibility to simultaneously measure multiple analytes, and the ability to assess the specificity of the analysis in every sample. All described analytical methods were extensively validated, utilized in routine diagnostic practice, and were applied in a number of clinical and epidemiological studies, including a study of the steroidogenesis in ovarian follicles. #

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Section: B Sample Preparationmentioning

confidence: 99%

Liquid chromatography-tandem mass spectrometry applications in endocrinology

Kushnir

Rockwood

Bergquist

2009

Mass Spectrom. Rev.

138

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“…Six LC columns with different column inner diameters, particle diameters and column lengths, four mobile phases and two LC systems were used for the validation of the mass sensitivity (Eqs. [10][11][12]. By comparing the theoretical mass sensitivity (m LOD,th ) calculated using Eq.…”

Section: Mass Limit Of Detection (M Lod )mentioning

confidence: 99%

Enhancing concentration and mass sensitivities for liquid chromatography trace analysis of clopyralid in drinking water

Meldrum

McCabe

et al. 2011

J of Separation Science

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A theoretical treatment was developed and validated that relates analyte concentration and mass sensitivities to injection volume, retention factor, particle diameter, column length, column inner diameter and detection wavelength in liquid chromatography, and sample volume and extracted volume in solid-phase extraction (SPE). The principles were applied to improve sensitivity for trace analysis of clopyralid in drinking water. It was demonstrated that a concentration limit of detection of 0.02 ppb (μg/L) for clopyralid could be achieved with the use of simple UV detection and 100 mL of a spiked drinking water sample. This enabled reliable quantitation of clopyralid at the targeted 0.1 ppb level. Using a buffered solution as the elution solvent (potassium acetate buffer, pH 4.5, containing 10% of methanol) in the SPE procedures was found superior to using 100% methanol, as it provided better extraction recovery (70-90%) and precision (5% for a concentration at 0.1 ppb level). In addition, the eluted sample was in a weaker solvent than the mobile phase, permitting the direct injection of the extracted sample, which enabled a faster cycle time of the overall analysis. Excluding the preparation of calibration standards, the analysis of a single sample, including acidification, extraction, elution and LC run, could be completed in 1 h. The method was used successfully for the determination of clopyralid in over 200 clopyralid monoethanolamine-fortified drinking water samples, which were treated with various water treatment resins.

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“…This system, consisting of a sample preparation unit (Prospekt), a liquid chromatograph, and a diode array detector, was successfully applied to the determination of pesticides in river water [18]. However, due to its design, energy consumption, number of mobile parts, and complexity, the SAMOS cannot be used as a tool for field sampling on regular basis.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of selected endocrine disrupters (pesticides, phenols and phthalates) in water by in-field solid-phase extraction (SPE) using the prototype PROFEXS followed by on-line SPE (PROSPEKT) and analysis by liquid chromatography-atmospheric pressure chemical ionisation-mass spectrometry

López-Roldán

Alda

Barceló

2004

Analytical and Bioanalytical Chemistry

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In this study, a new procedure, based on on-line solid-phase extraction (SPE) and analysis by liquid-chromatography-atmospheric pressure chemical ionization-mass spectrometry (LC-APCI-MS), has been developed for the simultaneous, multianalyte determination of 21 selected pesticides, phenols and phthalates in water. SPE was carried out on polymeric PLRP-s cartridges by percolating 20 mL-samples. For sample preconcentration, the performance of a prototype programmable field extraction system (PROFEXS) was evaluated against the commercial laboratory bench Prospekt system used for method development. The Profexs is designed for the automated on-site sampling, SPE preconcentration, and storage of up to 16 samples in SPE cartridges. These cartridges are further eluted and on-line analyzed with the Prospekt coupled to the chromatographic system. In the optimized method, where completely on-line SPE-LC-MS analysis of the samples is carried out with the Prospekt in the laboratory, detection limits lower than 100 ng/L, and satisfactory precision (relative standard deviations <25%) and accuracies (recovery percentages >75%) were obtained for most investigated compounds from the analysis of spiked Milli-Q water. The extraction efficiency achieved with the Profexs was comparable to that of the Prospekt for most compounds and somewhat lower for the most apolar analytes, probably due to adsorption on the pump filters. The completely on-line optimized method was applied to the analysis of surface water, ground water and drinking water from a waterworks in Barcelona. Some pesticides and phenols were found in both surface water and groundwater at ng/L or microg/L levels, but not in the final drinking water. Di(2-ethylhexyl)phthalate (DEHP) was present in all samples investigated, including blanks. To the author's knowledge, this is the first work describing the application of a fully automated on-line SPE-LC-MS method for the simultaneous analysis of pesticides, phenols, and phthalates in water, and the second one that examines the possibilities of the prototype Profexs for automated on-site SPE preconcentration of organic pollutants from water samples.

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Monitoring of pesticides in river water using fully automated on-line solid-pase extraction and liquid chromatography with diode array detection with a novel filtration device

Cited by 44 publications

References 14 publications

Liquid chromatography-tandem mass spectrometry applications in endocrinology

Liquid chromatography-tandem mass spectrometry applications in endocrinology

Enhancing concentration and mass sensitivities for liquid chromatography trace analysis of clopyralid in drinking water

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