Monitoring of metabolic side-effects in children and adolescents prescribed antipsychotic medication: A systematic review

Mead, Laura E.; Ayres, Alice; Blake, Julie A.; Scott, James G.

doi:10.1177/00048674211009620

Cited by 5 publications

(1 citation statement)

References 37 publications

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“…Previous literature showed that the first-line antidepressants may not achieve satisfactory effect in 60% of adolescents with MDD (14). Some limitations associated with interventions for acute onset of adolescents with mental disorders include slow effectiveness, lack of well-tolerated and effective pharmaceuticals, and limited pharmaceutical therapeutic options (15,16). Besides that, there are hidden safety risks in antidepressant medication, such as selective serotonin reuptake inhibitors (SSRIs) could increase the risk of suicidality and self-injury in youth (17,18).…”

Section: Introductionmentioning

confidence: 99%

Electroconvulsive therapy efficacy in adolescents with mental illness: A retrospective comparison

Zhang

Lei

et al. 2022

Front. Psychiatry

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BackgroundThere is limited evidence on the efficacy of electroconvulsive therapy (ECT) in adolescents with mental illness. The present study reported outcomes of adolescents with mental illness treated with ECT aimed at providing evidence for large-scale feasibility.ObjectivesThe primary objective of this trial was to examine the differences in demographic and clinical data between responders and non-responders. The secondary objective was to determine whether ECT produced differential readmission rates, the burden of oral medication, and social function in responders and non-responders in the long term.MethodsPatients aged 14–18 years diagnosed with schizophrenia (SCZ), major depressive disorder (MDD), or bipolar disorder (BD) who received ECT between 2015 and 2020 were included in the study. Demographic and clinical data were compared, and both short-term and long-term outcomes were assessed: response on the Clinical Global Impressions-Improvement scale and readmission at follow-up. The independent-sample t–test was used to compare the continuous variables and the X2 test was used to compare the dichotomous variables with statistical significance at P ≤ 0.05.ResultsFour hundred ten adolescents (aged 14–18 years, 53.90% female) received ECT for SCZ, MDD, and BD. The response rate for SCZ, MDD, and BD were 65.61, 78.57, and 69.95%, respectively. Both SCZ (P = 0.008) and BD (P = 0.008) groups had a significant elder age in responders than in non-responders. Besides that MDD responders had a significantly larger number of ECT sessions than non-responders (P = 0.046), the study failed to find a significant difference in other ECT parameters. A significantly higher proportion of readmission was found in BD non-responders than in responders (P = 0.029), there was no difference in the rate of readmission in other diagnostic groups.ConclusionsThese data suggested that ECT is an effective treatment for adolescents with severe mental illness, and the rate of readmission was low in the long term. The present study supports that large-scale systematic studies are warranted for further investigation of the response rate of ECT for treating adolescents with mental illness.

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Section: Introductionmentioning

confidence: 99%

Electroconvulsive therapy efficacy in adolescents with mental illness: A retrospective comparison

Zhang

Lei

et al. 2022

Front. Psychiatry

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Metabolic Monitoring for Adults Living with a Serious Mental Illness on a Second-Generation Antipsychotic Agent: A Scoping Review

Bui,

Au,

Janetzki

et al. 2024

Adm Policy Ment Health

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Premature mortality in people living with a severe mental illness (SMI) is often attributed to multiple factors including the use of medicines such as antipsychotics. Second-generation antipsychotics (SGAs) are known to cause metabolic syndrome which can increase the risk of cardiovascular disease. Practice guidelines have recommended regular physical health monitoring, particularly of metabolic parameters, however, metabolic monitoring for people living with SMI using antipsychotics remains suboptimal. Therefore, highlighting the need for ongoing research. This scoping review aimed to provide an overview of current metabolic monitoring practices. We anticipate that this information will assist clinicians and policymakers and inform future research. The following databases were searched: MEDLINE (Ovid), Embase (Ovid), CINAHL (EBSCO), the Cochrane Database of Systemic Reviews (Wiley), APA PsycInfo (Ovid) and Scopus (Elsevier Science Publishers). The target group was adults (aged ≥ 18) diagnosed with SMI (including bipolar disorder, major depressive disorder and psychotic disorders) and taking SGAs. In total, 44 studies from 14 countries were retrieved. Our findings highlighted that most studies conducted in hospitals did not report on metabolic monitoring practices. Additionally, the roles and responsibilities of healthcare professionals in metabolic monitoring for SMI were infrequently described and parameters such as waist circumference and BMI were often poorly monitored. The scoping review highlights that no streamlined approach towards metabolic monitoring currently exists. There is a need to stipulate and define the roles and responsibilities of all health professionals involved in metabolic monitoring in SMI to optimise care for these individuals. Moreover, there is a need for ongoing research, particularly in the community setting, to promote increased accessibility to metabolic monitoring for SMI.

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Effect of antipsychotics and mood stabilisers on metabolism in bipolar disorder: a network meta-analysis of randomised-controlled trials

Kong,

Wang,

Yan

et al. 2024

eClinicalMedicine

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Monitoring of metabolic side-effects in children and adolescents prescribed antipsychotic medication: A systematic review

Cited by 5 publications

References 37 publications

Electroconvulsive therapy efficacy in adolescents with mental illness: A retrospective comparison

Electroconvulsive therapy efficacy in adolescents with mental illness: A retrospective comparison

Metabolic Monitoring for Adults Living with a Serious Mental Illness on a Second-Generation Antipsychotic Agent: A Scoping Review

Effect of antipsychotics and mood stabilisers on metabolism in bipolar disorder: a network meta-analysis of randomised-controlled trials

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