Monitoring of levels of polycyclic aromatic hydrocarbons in bees caught from beekeeping: remark 1

Amorena, Michele; Visciano, Pierina; Giacomelli, Alessandra; Marinelli, E.; Sabatini, A. G.; Mędrzycki, Piotr; Oddo, Livia Persano; Pace, F.; Belligoli, P.; Serafino, Gabriella Di; Saccares, S.; Formato, Giovanni; Langella, V.; Perugini, Monia

doi:10.1007/s11259-009-9283-7

Cited by 15 publications

(7 citation statements)

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“…When TCA19 signature was evaluated in subgroup containing stage III elderly patients, a tendency towards benefit from adjuvant chemotherapy in TCA19‐based high‐risk patients was observed. Although elderly patients with stage III disease have often been excluded from standard chemotherapy, patients older than 75 years reportedly had a similar survival benefit from fluorouracil‐based treatment as younger patients (Amorena et al., 2009; Verbeek, 2008). Therefore, traditional chemotherapy appears to benefit elderly stage III patients who were identified as a high‐risk group by TCA19, while alternative chemotherapy using 2nd‐ or 3rd‐line may be required for those in the low‐risk group.…”

Section: Discussionmentioning

confidence: 99%

A nineteen gene‐based risk score classifier predicts prognosis of colorectal cancer patients

et al. 2014

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Colorectal cancer (CRC) patients frequently experience disease recurrence and distant metastasis. This study aimed to identify prognostic indicators, including individual responses to chemotherapy, in CRC patients. RNA-seq data was generated using 54 samples (normal colon, primary CRC, and liver metastases) from 18 CRC patients and genes associated with CRC aggressiveness were identified. A risk score based on these genes was developed and validated in four independent CRC patient cohorts (n = 1063). Diverse statistical methods were applied to validate the risk scoring system, including a generalized linear model likelihood ratio test, Kaplan-Meier curves, a log-rank test, and the Cox model. TREM1 and CTGF were identified as two activated regulators associated with CRC aggressiveness. A risk score based on 19 genes regulated by TREM1 or CTGF activation (TCA19) was a significant prognostic indicator. In multivariate and subset analyses based on pathological staging, TCA19 was an independent risk factor (HR = 1.894, 95% CI = 1.227-2.809, P = 0.002). Subset stratification in stage III patients revealed that TCA19 had prognostic potential and identified patients who would benefit from adjuvant chemotherapy, regardless of age. The TCA19 predictor represents a novel diagnostic tool for identifying high-risk CRC patients and possibly predicting the response to adjuvant chemotherapy.

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Section: Discussionmentioning

confidence: 99%

A nineteen gene‐based risk score classifier predicts prognosis of colorectal cancer patients

et al. 2014

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“…Furthermore, together with honeybees, they can be harmful to humans and animals due to their sting. Particularly aggressive is V. velutina nigritorax that can attack humans and animals if the nest is threatened [ 25 , 26 , 27 ].…”

Section: Insects and Diseasesmentioning

confidence: 99%

Insects and Public Health: An Overview

Belluco

Bertola

Montarsi

et al. 2023

Insects

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Insects are, by far, the most common animals on our planet. The ubiquity and plethora of ecological niches occupied by insects, along with the strict and sometimes forced coexistence between insects and humans, make insects a target of public health interest. This article reports the negative aspects historically linked to insects as pests and vectors of diseases, and describes their potential as bioindicators of environmental pollution, and their use as food and feed. Both negative and positive impacts of insects on human and animal health need to be addressed by public health professionals who should aim to strike a balance within the wide range of sometimes conflicting goals in insect management, such as regulating their production, exploiting their potential, protecting their health and limiting their negative impact on animals and humans. This requires increased insect knowledge and strategies to preserve human health and welfare. The aim of this paper is to provide an overview of traditional and emerging topics bridging insects and public health to highlight the need for professionals, to address these topics during their work. The present and future role and activities of public health authorities regarding insects are analyzed.

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“…Bioindicators can be further distinguished into four categories depending on the application, namely ecological, environmental, biodiversity, and pollution bioindicators [ 145 ]. A. mellifera represents, together with its products, the most complete biosensor (bioindicator and bioaccumulator), which can provide a considerable amount of data on the state of health of the environment [ 146 , 147 , 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 ]. Each forager bee manages to cover a foraging distance of more than 3 km from the hive and, in some cases, the area covered can be up to 100 km 2 [ 156 , 157 ].…”

Section: Honey Bees and Bee Products To Safeguard Ecosystems From Pol...mentioning

confidence: 99%

The Honey Bee Apis mellifera: An Insect at the Interface between Human and Ecosystem Health

Papa

Maier

Durazzo³

et al. 2022

Biology

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The concept of ecosystem services is widely understood as the services and benefits thatecosystems provide to humans, and they have been categorised into provisioning, regulating, supporting, and cultural services. This article aims to provide an updated overview of the benefits that the honey bee Apis mellifera provides to humans as well as ecosystems. We revised the role of honey bees as pollinators in natural ecosystems to preserve and restore the local biodiversity of wild plants; in agro-ecosystems, this species is widely used to enhance crop yield and quality, meeting the increasing food demand. Beekeeping activity provides humans not only with high-quality food but also with substances used as raw materials and in pharmaceuticals, and in polluted areas, bees convey valuable information on the environmental presence of pollutants and their impact on human and ecosystem health. Finally, the role of the honey bee in symbolic tradition, mysticism, and the cultural values of the bee habitats are also presented. Overall, we suggest that the symbolic value of the honey bee is the most important role played by this insect species, as it may help revitalise and strengthen the intimate and reciprocal relationship between humans and the natural world, avoiding the inaccuracy of considering the ecosystems as mere providers of services to humans.

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Monitoring of levels of polycyclic aromatic hydrocarbons in bees caught from beekeeping: remark 1

Cited by 15 publications

References 1 publication

A nineteen gene‐based risk score classifier predicts prognosis of colorectal cancer patients

A nineteen gene‐based risk score classifier predicts prognosis of colorectal cancer patients

Insects and Public Health: An Overview

The Honey Bee Apis mellifera: An Insect at the Interface between Human and Ecosystem Health

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