Monitoring of immunotherapy by measuring monocyte HLA-DR expression and stimulated TNFα production during sepsis after liver transplantation

Denzel, C.; Riese, Jutta; Hohenberger, Werner; Born, G.; Köckerling, F.; Tschaikowsky, K.; Reith, H. B.; Reck, T.; Haupt, W

doi:10.1007/s001340050775

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Transplant-related Immunosuppression1

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Cited by 6 publications

(2 citation statements)

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“…Although these were not controlled trials, these therapies were generally well tolerated and not associated with adverse events. Reports of cytokine therapy used in transplant patients have suggested at least the safety of IFNγ, which may be used without injury to the graft (51, 52).…”

Section: Discussionmentioning

confidence: 99%

Human leukocyte antigen‐DR expression on peripheral blood monocytes and the risk of pneumonia in pediatric lung transplant recipients

Hoffman¹,

Weinberg²,

Azen³

et al. 2004

Transplant Infectious Dis

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Persistent low monocyte HLA-DR expression was associated with the risk of post-LT pneumonia in these patients. This measurement may be useful for monitoring risk of infection and stratifying patients into higher and lower risk groups. Increased IL-10 levels may be protective for infection in this group of patients. At present it is unknown whether the predictive power of HLA-DR expression is indicative of a global defect in monocytic function or a specific abnormality.

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Section: Discussionmentioning

confidence: 99%

Human leukocyte antigen‐DR expression on peripheral blood monocytes and the risk of pneumonia in pediatric lung transplant recipients

Hoffman¹,

Weinberg²,

Azen³

et al. 2004

Transplant Infectious Dis

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show abstract

“…Some investigators have employed immunostimulatory therapy with either IFNγ or GM-CSF for the treatment of post-transplant septic disease [86,87], however prospective, standardized trials are lacking. Monocyte HLA-DR expression measurement and quantification of the ex vivo LPS-induced TNFα response both appear to have the potential to provide insight into the degree of functional immunosuppression following transplantation and are deserving of future study in this regard.…”

Section: Transplant-related Immunosuppressionmentioning

confidence: 99%