Monitoring of<i>Clostridium difficile</i>Colonization in Preterm Infants in Neonatal Intensive Care Units

Chang, Ju Young; Shim, Jung Ok; Ko, Jae Sung; Lee, Jin A; Kim, Han Suk; Choi, Jung Hwan; Shin, Sue; Shin, Son Moon

doi:10.5223/pghn.2012.15.1.29

Cited by 4 publications

(3 citation statements)

References 35 publications

(45 reference statements)

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“…The most likely source in infants is from environmental contamination rather than direct maternal infant transmission. Chang et al [ 13 ] reported that the toxin positivity rate is significantly higher in the infants with persistent C. difficile colonization than in those with transient colonization (66.7% vs. 24.5%, p =0.001). Exclusive breast-milk feeding decreases the risk of persistent colonization compared to formula or mixed feeding.…”

Section: Characteristics Of Clostridium Difficile mentioning

confidence: 99%

Clostridium difficilein Children: To Treat or Not to Treat?

Shim

2014

Pediatr Gastroenterol Hepatol Nutr

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Clostridium difficile infection has been increasing since 2000 in children and in adults. Frequent antibiotics use, comorbidity, and the development of hypervirulent strains have increased the risk of infection. Despite the high carriage rates of C. difficile, infants rarely develop clinical infection. Discontinuing antibiotics and supportive management usually leads to resolution of disease. Antibiotics use should be stratified depending on the patient's age and severity of the disease.

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Section: Characteristics Of Clostridium Difficile mentioning

confidence: 99%

Clostridium difficilein Children: To Treat or Not to Treat?

Shim

2014

Pediatr Gastroenterol Hepatol Nutr

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“…Notably, most strains isolated by culture were non-toxigenic (92.9%). The reported rates of C. difficile colonization in PN are highly variable and originate primarily from outdated, singlecenter, culture-based studies (Cardines et al, 1988;Chang et al, 2012;Pichler et al, 2018). The C. difficile colonization rates depend on the detection method used.…”

Section: Discussionmentioning

confidence: 99%

“…Asymptomatic Clostridioides difficile colonization with both toxigenic and non-toxigenic strains has been reported in 17–70% of healthy children less than three years of age ( Enoch et al., 2011 ; Jangi and Lamont, 2010 ; Rousseau et al., 2011 ; Stoesser et al., 2017 ). Among pediatric populations, few studies have targeted C. difficile colonization in preterm neonates (PN); moreover, these studies are either outdated or based on culturing approaches ( Cardines et al., 1988 ; el-Mohandes et al., 1993 ; Tina et al., 1994 ; Chang et al., 2012 ; Ferraris et al., 2012 ; Pichler et al., 2018 ). Depending on the study, the colonization rate in PN ranges from 0% ( Tina et al., 1994 ) to 63% ( Cardines et al., 1988 ) and increases during the first month of life.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota Diversity of Preterm Neonates Is Associated With Clostridioides Difficile Colonization

Couturier

Lepage

Jolivet

et al. 2022

Front. Cell. Infect. Microbiol.

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In adults, Clostridioides difficile infections are associated with alterations of the intestinal bacterial populations. Although preterm neonates (PN) are frequently colonized by C. difficile, limited data are available regarding the relationship between C. difficile and the intestinal microbiota of this specific population. Therefore, we studied the intestinal microbiota of PN from two multicenter cohorts using high-throughput sequencing of the bacterial 16S rRNA gene. Our results showed that alpha diversity was significantly higher in children colonized by C. difficile than those without colonization. Beta diversity significantly differed between the groups. In multivariate analysis, C. difficile colonization was significantly associated with the absence of postnatal antibiotherapy and higher gestational age. Taxa belonging to the Lachnospiraceae, Enterobacteriaceae, Oscillospiraceae families and Veillonella sp. were positively associated with C. difficile colonization, whereas Bacteroidales and Bifidobacterium breve were negatively associated with C. difficile colonization. After adjustment for covariables, Clostridioides, Rothia, Bifidobacterium, Veillonella, Eisenbergiella genera and Enterobacterales were more abundant in the gut microbiota of colonized children. There was no significant association between C. difficile colonization and necrotizing enterocolitis in PN. Our results suggest that C. difficile colonization in PN is related to the establishment of physiological microbiota.

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A nationwide study of molecular epidemiology and antimicrobial susceptibility of Clostridioides difficile in South Korea

Byun

Kim

et al. 2019

Anaerobe

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Monitoring ofClostridium difficileColonization in Preterm Infants in Neonatal Intensive Care Units

Cited by 4 publications

References 35 publications

Clostridium difficilein Children: To Treat or Not to Treat?

Clostridium difficilein Children: To Treat or Not to Treat?

Gut Microbiota Diversity of Preterm Neonates Is Associated With Clostridioides Difficile Colonization

A nationwide study of molecular epidemiology and antimicrobial susceptibility of Clostridioides difficile in South Korea

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