Monitoring of high-load dose formulations based on co-processed and non co-processed excipients

Sierra-Vega, Nobel O.; Karry, Krizia M.; Romañach, Rodolfo J.; Méndez, Rafael

doi:10.1016/j.ijpharm.2021.120910

Cited by 7 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development of these co-processed excipients often involved fluid-bed granulation and spray drying, among others [ 44 , 46 ]. In the earlier studies, the aim of co-processed pharmaceutical excipients is to acquire a new composite excipient with better functional properties than the raw excipient [ 46 , 47 ]. The co-processed excipients are also popular in direct compaction since they have excellent key direct compaction properties that could effectively improve the direct compaction properties of drug powders.…”

Section: Introductionmentioning

confidence: 99%

Surface Modifiers on Composite Particles for Direct Compaction

Chen

Liu²,

Zhu³

et al. 2022

Pharmaceutics

View full text Add to dashboard Cite

Direct compaction (DC) is considered to be the most effective method of tablet production. However, only a small number of the active pharmaceutical ingredients (APIs) can be successfully manufactured into tablets using DC since most APIs lack adequate functional properties to meet DC requirements. The use of suitable modifiers and appropriate co-processing technologies can provide a promising approach for the preparation of composite particles with high functional properties. The purpose of this review is to provide an overview and classification of different modifiers and their multiple combinations that may improve API tableting properties or prepare composite excipients with appropriate co-processed technology, as well as discuss the corresponding modification mechanism. Moreover, it provides solutions for selecting appropriate modifiers and co-processing technologies to prepare composite particles with improved properties.

show abstract

Section: Introductionmentioning

confidence: 99%

Surface Modifiers on Composite Particles for Direct Compaction

Chen

Liu²,

Zhu³

et al. 2022

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…In recent years, NIR and Raman spectroscopy have been used to monitor drug concentrations at the feed frame, immediately before tablets are compressed. [8][9][10] The feed frame, and a stream sampler currently under development, are the main agents for meeting the Fundamental Sampling Principle (FSP) in which all parts of a moving lot must have the same opportunity of being sampled for analysis. 11 NIR and Raman spectroscopic methods are essential parts of real-time monitoring and control approaches within the field of PAT.…”

Section: Sampling Special Section Sampling Special Sectionmentioning

confidence: 99%