Monitoring of early nephrotoxic effects of industrial chemicals

Lauwerys, Robert; Bernard, Alfred; Cardenas, A

doi:10.1016/0378-4274(92)90170-o

Cited by 26 publications

(12 citation statements)

References 9 publications

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“…Higher serum β 2 -microglobulin was observed in acute lung injury due to increased glomerular permeability associated with a generalized inflammatorymediated increase in vascular permeability, in addition to that in the lung (Doyle et al, 1999). This pathological condition resulted in this study in the most characteristic manifestation of NOx occupational exposure-related changes-an enhanced level of β 2 M-S (Table 3 and Figure 2), postulated as an endogenous marker for the detection of reduction glomerular filtration rate after exposure to industrial chemicals such as cadmium (Mason et al, 1988;Lauwerys et al, 1992;Taylor et al, 1997).…”

Section: Figmentioning

confidence: 64%

Serum Clara-Cell Protein and β₂-Microglobulin as Early Markers of Occupational Exposure to Nitric Oxides

Hałatek

Gromadzińska

Wąsowicz

et al. 2005

Inhalation Toxicology

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Biochemical effects of NOx on 60 workers (both genders) of nitric acid production were studied. The control group consisted of 61 nonexposed people employed elsewhere in the plant. Although the actual threshold limit valuetime weighted averages (TLV-TWA) were not exceeded in the specific conditions of our study, the subjects were exposed to NO2 and NO during several exposure episodes with peak maximal concentrations of 140 ppm and 515 ppm, respectively. Additional cross-week evaluation of several biochemical biomarkers in 15 NOx-exposed workers from one shift was performed. The objective of the study was to evaluate the value of serum Clara-cell protein (CC16) as a marker of bronchoalveolar epithelium activity. Antioxidant status was assessed by measuring activity of enzymes: glutathione peroxidase (GSH-Px), ceruloplasmin (Cp) in plasma, or superoxide dismutase (SOD), gluthatione S-transferase (GST), and nonenzymatic alpha-tocopherol in erythrocytes and thiobarbituric acid-reactive substances (TBARS) in plasma. Serum hyaluronic acid (HA) determining the connective tissue matrix status of airways, and beta2-microglobulin in serum (beta2M-S) and urine (beta2M-U) as a marker of renal function in occupational exposure to NOx were also employed. Exposure to NOx initiates peroxidative chain depleting of lipoprotein pool (alpha-tocopherol) in blood. Serum CC16 levels in NOx-exposed workers were found to be closely connected with alpha-tocopherol content. In NOx-exposed workers, the beta2M-S level was significantly higher than in the nonexposed ones, with the exception of smokers. Results of the cross-week study confirm cumulative systemic effects of NOx on several examined biomarkers. SOD and GST were found to be depleted. A transient higher level of HA after a 5-d shift significantly inversely correlated with CC16 level. The data imply that NOx-depleted levels of CC16 are detectable already after an 8-h shift. Our results demonstrate that even low NOx human exposure can cause characteristic changes in bronchiolar epithelium cells and renal effects. Serum CC16 level, although a nonspecific marker, was lowest in NOx-exposed subjects. The most sensitive parameters in exposed workers were beta2M-S and a-tocopherol. Spirometric assessment was not useful to describe low occupational exposure to NOx. In studying the effects of NOx on biomarkers, it is essential to carefully select suitable time of sampling. Screening of CC16, beta2M-S, and a-tocopherol can be successfully employed for biological monitoring of exposure to NOx.

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Section: Figmentioning

confidence: 64%

Serum Clara-Cell Protein and β₂-Microglobulin as Early Markers of Occupational Exposure to Nitric Oxides

Hałatek

Gromadzińska

Wąsowicz

et al. 2005

Inhalation Toxicology

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“…To accomplish it, we used markers of early renal disease, such as the NAG enzymatic activity (Lauwerys et al 1992;Mueller 1993;Price 2000Price , 2002, and the urinary albumin excretion (Mueller et al 1995;Weiner and Sarnak 2003). The values that we obtained for the NAG activity were less than 0.5 lmolmin À1 /mmol of creatinine (3.8 lmol*min À1 /g creatinine), as proposed by Stengel et al (1999).…”

Section: Discussionmentioning

confidence: 83%

Occupational exposure to toluene and its possible causative role in renal damage development in shoe workers

Ana-Lilia

Kornhauser

Wróbel

et al. 2005

Int Arch Occup Environ Health

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“…Diabetes-induced renal pathology may be observed earlier in patients that are exposed chronically to low levels of Cd compared with un-exposed patients. This theory is supported by studies comparing streptozotocin-induced diabetic Wistar rats and non-diabetic Wistar rats [201]. The findings from these studies showed that urinary levels of protein, NAG, and γ-glutamyltransferase were greater in diabetic rats than in controls, suggesting that renal damage was more extensive in diabetic rats [201].…”

Section: Environmentally Relevant Toxic Metalsmentioning

confidence: 90%

Chronic Kidney Disease and Exposure to Nephrotoxic Metals

Orr

Bridges

2017

IJMS

269

110

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Chronic kidney disease (CKD) is a common progressive disease that is typically characterized by the permanent loss of functional nephrons. As injured nephrons become sclerotic and die, the remaining healthy nephrons undergo numerous structural, molecular, and functional changes in an attempt to compensate for the loss of diseased nephrons. These compensatory changes enable the kidney to maintain fluid and solute homeostasis until approximately 75% of nephrons are lost. As CKD continues to progress, glomerular filtration rate decreases, and remaining nephrons are unable to effectively eliminate metabolic wastes and environmental toxicants from the body. This inability may enhance mortality and/or morbidity of an individual. Environmental toxicants of particular concern are arsenic, cadmium, lead, and mercury. Since these metals are present throughout the environment and exposure to one or more of these metals is unavoidable, it is important that the way in which these metals are handled by target organs in normal and disease states is understood completely.

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Monitoring of early nephrotoxic effects of industrial chemicals

Cited by 26 publications

References 9 publications

Serum Clara-Cell Protein and β₂-Microglobulin as Early Markers of Occupational Exposure to Nitric Oxides

Serum Clara-Cell Protein and β₂-Microglobulin as Early Markers of Occupational Exposure to Nitric Oxides

Occupational exposure to toluene and its possible causative role in renal damage development in shoe workers

Chronic Kidney Disease and Exposure to Nephrotoxic Metals

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Monitoring of early nephrotoxic effects of industrial chemicals

Cited by 26 publications

References 9 publications

Serum Clara-Cell Protein and β2-Microglobulin as Early Markers of Occupational Exposure to Nitric Oxides

Serum Clara-Cell Protein and β2-Microglobulin as Early Markers of Occupational Exposure to Nitric Oxides

Occupational exposure to toluene and its possible causative role in renal damage development in shoe workers

Chronic Kidney Disease and Exposure to Nephrotoxic Metals

Contact Info

Product

Resources

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Serum Clara-Cell Protein and β₂-Microglobulin as Early Markers of Occupational Exposure to Nitric Oxides

Serum Clara-Cell Protein and β₂-Microglobulin as Early Markers of Occupational Exposure to Nitric Oxides