Monitoring of Cd, Hg, Pb, and As and Risk Assessment for Commercial Medicinal Plants

Kim, Hyuck-Soo; Kim, Kwon-Rae; Hong, Chang-Oh; Go, Woo-Ri; Jeong, Seon-Hee; Yoo, Ji‐Hyock; Cho, Namjun; Hong, Jin-Hwan; Kim, Won-Il

doi:10.5338/kjea.2015.34.4.43

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…Accordingly, the common involvement of IL-6 might explain the overlapping clinical parameters observed in HLH, IKD, SoJIA and PFAPA. KD had been described as a precursor of secondary HLH, particularly IKD or IVIG-nonresponsive KD (9)(10)(11)(45)(46)(47)(48), but HLH was also observed before the diagnosis of KD (49). MAS complicated with KD was observed in some cases (50)(51)(52).…”

Section: Discussionmentioning

confidence: 99%

“…MAS usually observed after the diagnoses of CTD, and HLH is the usually diagnosis for patients without diagnoses of CTD. KD was considered to be a precursor of HLH (9)(10)(11), and the incidence of SoJIA in HLH or KD patients has not been reported. HLH/MAS is only reported in one case from 114 cases of HIDS/MVKD (12) and not reported in FMF, CAPS, TRAPS and PFAPA.…”

Section: Introductionmentioning

confidence: 99%

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Severe Recurrent Fever Episodes With Clinical Diagnosis of Hemophagocytic Lymphohistiocytosis, Incomplete Kawasaki Disease and Systemic-Onset Juvenile Idiopathic Arthritis: A Case Report and Literature Review

Jiang

Yang

2020

Front. Pediatr.

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The pathogeneses of recurrent fever are quite complicated when excluding repeated infections. Recurrent fever is a common symptom for autoinflammatory diseases, relapse of Systemic-onset juvenile idiopathic arthritis (SoJIA) and recurrent Kawasaki disease (KD). There are no specific diagnostic laboratory tests for the diseases. Some studies showed that KD was the precursor of hemophagocytic lymphohistiocytosis (HLH). Macrophage activation syndrome (MAS) is another form of HLH in SoJIA. Cytokine disturbances are considered to be involved in the pathogenesis of the diseases. We describe a Chinese female toddler that developed three separate fever episodes with eventual diagnose of SoJIA within about 10 months. The first episode was diagnosed as IKD, immunoglobulin nonresponsive KD, and HLH. The second and third episodes were diagnosed as IKD and SoJIA, respectively. The fever was hard to be relieved by antipyretics, and the peak axillary temperature was above 40 • C. For every fever episode, infections were excluded. For the first episode, trends over time of hemoglobin, platelets, fibrinogen, and triglycerides indicated HLH, which was finally diagnosed and treated according to the HLH-2004 protocol. For the second episode 6 months later, after excluding an HLH relapse and infections, IKD was finally diagnosed. Oral aspirin was administered, and the HLH treatment was ceased. The third episode occurred 3 months later, and SoJIA was finally diagnosed. For each episode, except for relative tests, we only tested for cytokines interleukin-1β, interleukin-6, and interferon-γ, due to limited laboratory test availability. These cytokines were elevated during remission and rose much higher in the fever phases. The case showed the difficulty to differentiating the recurrent fever in clinical practice. Surveillance of routine laboratory parameters over time might reveal a trend that indicates possible disease, even when parameter values Jiang and Yang Severe Recurrent Fever Episodes do not meet diagnostic criteria. Changes in cytokine profiles are promising markers for differentiating recurrent fever diseases in future. An unknown immunological defect for the case may contribute to the recurrent immunological insults, and we are following up the recurrence of fever episode.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Severe Recurrent Fever Episodes With Clinical Diagnosis of Hemophagocytic Lymphohistiocytosis, Incomplete Kawasaki Disease and Systemic-Onset Juvenile Idiopathic Arthritis: A Case Report and Literature Review

Jiang

Yang

2020

Front. Pediatr.

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“…Mean and maximum value of HQ and CR for As, Cd, Hg and Pb concentrations in Angelica gigas and Cnidium officinale grown at the major producing districts in Korea. (9.63 × 10 -2 ) † 6.17 × 10 -3 (2.17 × 10 -2 ) 3.12 × 10 -4 (1.05 × 10 -3 ) 7.22 × 10 -3 (4.26 × 10 -2 ) 4.41 × 10 -2 (1.62 × 10 -1 ) 1.37 × 10 -5 (4.33 × 10 -5 ) Cnidium officinale 1.27 × 10 -2 (3.91 × 10 -2 ) 3.45 × 10 -3 (1.22 × 10 -2 ) 2.35 × 10 -4 (3.37 × 10 -4 ) 2.18 × 10 -3 (6.12 × 10 -3 ) 1.85 × 10 -2 (5.77 × 10 -2 ) 5.71 × 10 -6 (1.76 × 10 -5 ) Introduction 오늘날 삶의 질적 수준이 향상되면서 건강에 대한 관심이 날로 증대되고 있고 과거 질병 치료 목적으로 이용되던 약 용작물이 최근에는 건강 예방 및 체력 회복을 위한 건강 기능성 식품으로도 활용되어 이로 인해 약용작물 관련 시장은 증가하는 추세이다 (Kim et al, 2015). 당귀 (Angelica gigas Nakai)는 조혈작용을 하여 혈허를 개선하고 혈액의 적혈 구 수치를 높이고, 비타민 E 결핍증에 작용하며 자궁발육을 촉진한다.…”

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Transition Characteristics and Risk Assessment of Heavy Metal(loid)s in Angelica gigas Nakai and Cnidium officinale Makino

Kim

Seo

et al. 2019

Korean J. Soil. Sci. Fert.

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This study was conducted to identify transition characteristics of heavy metal(loid)s and to assess dietary risk in the Angelica gigas and Cnidium officinale grown at the major medicinal plant producing districts in Korea. Average bio-concentration factor (BCF) values and range were 0.056 (0.006-0.511) in arsenic (As), 2.030 (0.021-15.678) in cadmium (Cd), 0.179 (0.052-0.393) in mercury (Hg), and 0.061 (0.013-0.474) in lead (Pb) in Angelica gigas. Average BCF values and range were 0.044 (0.011-0.264) in As, 0.557 (0.052-4.255) in Cd, 0.174 (0.069-0.286) in Hg, and 0.024 (0.012-0.057) in Pb in Cnidium officinale. The BCF values by heavy metal(loid)s in Angelica gigas and Cnidium officinale were high in Cd, copper (Cu) and zinc (Zn), while As and Pb were found to be less transferable. The BCF values calculated in this study will be useful for predicting the uptake of heavy metal(loid)s. Human exposure to As, Cd, Hg, and Pb through dietary intake of Angelica gigas and Cnidium officinale might not cause adverse health effects although some Angelica gigas were higher than the allowable value for Cd. Further study on uptake and accumulation mechanism of Cd by Angelica gigas is required to assess the human health risk associated with soil contamination.

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“…그동안 국내의 약용작물에 관한 연구는 재배적지 선정, 비배관리 및 작물체의 유효성분과 무기성분과의 관계 등에 대한 연구가 수행되었고 (Jung et al, 1996;Park et al, 1989) Kim et al, 2015;Lee et al, 2011;Mondal and Polya, 2008). Concern levels for soil contamination described in Soil Environmental Conservation Act (MOE, 2011).…”

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“…Concern levels for soil contamination described in Soil Environmental Conservation Act (MOE, 2011). 으로 조사되어 기존의 유사한 범위를 보였다 (Kim et al, 2015). 또한 우리나라 재배 도라지 중 납의 함량과 범위인 0.67 mg kg -1 (0.30~1.10 mg kg -1 DW)인 결과와도 유사 하였다 (Bae et al, 2014).…”

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Identification of Transition Characteristics and Bio-concentration Factors of Heavy Metal (loid)s in the Selected Perennial Root Medicinal Plants

Kim¹,

Noh²,

Hong³

et al. 2017

Korean J. Soil. Sci. Fert.

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This study was conducted to identify transition characteristics of arsenic (As), cadmium (Cd), and lead (Pb) and to calculate bio-concentration factors (BCF) in the three perennial root medicinal plants, namely The BCF values calculated in this study will be useful for predicting the uptake of heavy metal (loid)s. Further study on uptake and accumulation mechanism of toxic metal (loid)s by agricultural products is required to assess the human health risk associated with soil contamination.

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Monitoring of Cd, Hg, Pb, and As and Risk Assessment for Commercial Medicinal Plants

Cited by 7 publications

References 11 publications

Severe Recurrent Fever Episodes With Clinical Diagnosis of Hemophagocytic Lymphohistiocytosis, Incomplete Kawasaki Disease and Systemic-Onset Juvenile Idiopathic Arthritis: A Case Report and Literature Review

Severe Recurrent Fever Episodes With Clinical Diagnosis of Hemophagocytic Lymphohistiocytosis, Incomplete Kawasaki Disease and Systemic-Onset Juvenile Idiopathic Arthritis: A Case Report and Literature Review

Transition Characteristics and Risk Assessment of Heavy Metal(loid)s in Angelica gigas Nakai and Cnidium officinale Makino

Identification of Transition Characteristics and Bio-concentration Factors of Heavy Metal (loid)s in the Selected Perennial Root Medicinal Plants

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