Monitoring of breast tissue thermo-ablation by means of impedance measurements

Lukaszewicz, K; Wtorek, Jerzy; Bujnowski, Adam; Skokowski, Jarosław

doi:10.1088/1742-6596/224/1/012136

Cited by 12 publications

(11 citation statements)

References 5 publications

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“…The management of breast cancer is achieved through various techniques like radiation, surgery, chemotherapy and endocrine therapy [37]. In this study majority patients of breast carcinoma, i.e.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Chemotherapy in Breast Cancer Patients

Anjum

Razvi²,

Saeed³

2017

Natl. j. health sci.

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Introduction: A descriptive, non-interventional study was conducted from April 2011 to September 2013, at KIRAN hospital, Karachi among n = 811 female breast cancer patients to assess the effects of chemotherapeutic agents that were employed for the treatment of breast cancer. The assessment was done so as to see the variation in response of the patients towards the drugs used specifically the adverse effects that have to be combated during therapy.Methodology: During 3-6 months, a follow up was done to collect data for ADEs (Adverse Drug Events) that occurred among patients after therapy. The SPSS version 16.0 was used for statistical analysis of the data. The adverse events that occurred due to adjuvant chemotherapy including severity, preventability and causality were evaluated using three International scales i.e. Modified Schumock and Thornton scale, modified Hartwig's and Siegal's scale and Naranjo's algorithm. Results and Discussion:Majority of the patients received 6 cycles of FAC therapy (5-fluorouracil, Adriamycin/doxorubicin, cyclophosphamide) and showed good response. The assessment of ADRs using different scales revealed hair loss, nausea, vomiting, anemia and neutropenia as the non-preventable definite effects that were experienced by the patients. Mild to moderate diarrhea/constipation was probably preventable and hence doubtful. Moderately probable effects included mucositis and mouth ulcers whereas possible effects included fever and chills. Conclusion:Through the right use of medicines, the mild effect of headache and pain could be certainly preventable. Hence chemotherapeutic agents must be chosen for each patient on individual basis to prevent or lessen the toxic effects rendered to them and be useful in the disease course.

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Section: Discussionmentioning

confidence: 99%

“…Breast carcinoma treatment includes different treatment modalities i.e. chemotherapy, adjuvant endocrine therapy and local treatment including radiation and surgery [10]. Due to their non-selectivity for cancer and normal cells, anti-cancer therapy causes adverse drug reactions along with their beneficial effects [11].…”

Section: Introductionmentioning

confidence: 99%

Effects of Chemotherapy in Breast Cancer Patients

Anjum

Razvi²,

Saeed³

2017

Natl. j. health sci.

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“…It measures electric permittivity and conductivity which are known to differ between normal and malignant tissue [12][13][14]. These parameters are lowest in fat tissue and are significantly lower than in cancerous tissue [15,16] thus allowing differentiation between these tissue states.…”

Section: Introductionmentioning

confidence: 99%

Dielectric-technique-assisted breast cancer surgery

Rząca¹,

Orzechowski²,

Wolny³

et al. 2017

Nowotwory. Journal of Oncology

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Introduction. In conservative breast cancer surgery, removing all carcinogenic lesions is a sound basis for achieving therapeutic success. The cleanness of the cutting margin is usually assessed after surgery and any residual cancerous tissue that are found, require further surgery. A simple and cheap assessment method is presented which can be used during surgery, the dielectric cancer probe (DCP), which allows the surgeon to take fast decisions on whether to extend incisions. Method. The DCP method consists of measuring and then differentiating between the electrical properties (permeability and conductivity) of healthy and cancerous breast tissue. A polyethylene strip is used to separate the examined tissue from the instrument probe and the procedure is carried out by the operating surgeon. Results. This method was found to allow correct identification of cancerous breast tissue based on taking 189 samples from 70 patients using the intraoperative hand probe. The sensitivity and specificity were respectively 87% and 99%. Conclusions. The DCP is a high sensitivity method and is totally safe for the patient and can be used intraoperatively. The device is an aid to the surgeon for differentiating between healthy and cancerous breast tissue. Its widespread use should reduce the number of reoperations in the conservative surgical management of breast cancer patients. NOWOTWORY J Oncol 2017; 67, 2: 108-114

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“…Excessive heat causes healthy tissue near the tumor to be destroyed, while insufficient heat will not lead to complete tumor irradiation. Although some of the methods such as those based on measuring tissue impedance 7 or MRI changes [8][9][10] have been developed, the methods either measure the treatment at limited areas or are significantly slow. This problem of temperature measurements decreases the efficiency of the ablation techniques and limits their clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Molecular thermometers for potential applications in thermal ablation procedures

et al. 2013

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Thermal ablation is a promising minimally invasive method for treating tumors without surgical intervention. Thermal ablation uses thermal sources such as lasers, radiowaves or focused ultrasound to increase the temperature of the tumor to levels lethal to cancer cells. This treatment based on heat therapy may be problematic as the temperature of the operation site is unknown. To address this problem, we developed optical molecular thermometers that can potentially measure the temperature on a molecular scale and be compatible with in vivo measurements. The thermometers are centered on a combination of two fluorophores emitting in two distinct spectral ranges and having different temperaturedependent emission properties. In this design, a fluorophore with relatively insensitive temperature-dependent fluorescence serves as a reference while another sensitive fluorophore serves as a sensor. We have demonstrated the feasibility of this approach using a coumarin-rhodamine conjugate. The sensitivity of the construct to the clinically relevant ablation temperatures (20-85 ºC) was demonstrated in vitro.

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Monitoring of breast tissue thermo-ablation by means of impedance measurements

Cited by 12 publications

References 5 publications

Effects of Chemotherapy in Breast Cancer Patients

Effects of Chemotherapy in Breast Cancer Patients

Dielectric-technique-assisted breast cancer surgery

Molecular thermometers for potential applications in thermal ablation procedures

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