1992
DOI: 10.1258/002367792780745904
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Monitoring of blood gas parameters and acid-base balance of pregnant and non-pregnant rabbits (Oryctolagus cuniculus) in routine experimental conditions

Abstract: SummaryBlood gas parameters and acid-base balance values were determined in adult pregnant New Zealand rabbits (Oryctolagus cuniculus) in standard laboratory housing conditions and during anaesthesia with an association of ketamine-chlorpromazine, administered before surgical procedures. All the variables were also studied in adult non-pregnant female, used as controls. No differences in pH, S02C, 02Hb, COHb, s02m and a-vD02 were found between pregnant and non-pregnant rabbits in physiologicalconditions and d… Show more

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Cited by 24 publications
(29 citation statements)
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“…While arterial blood gas values in rabbits have been reported before, these have been from small groups of animals, often as part of anaesthesia studies. Most of these studies have involved sedated or anaesthetised rabbits with variable fraction of inspired oxygen (FiO 2 ) values, or using intermittent positive pressure ventilation, which will influence the values reported (Raemer and others 1983, Egbrink and others 1989, Sakai and others 1999, Allweiler and others 2010) There is only one previous report from non-anaesthetised New Zealand laboratory rabbits, which produced mean values of 102 mm Hg which is higher than the values reported here (Barzago and others 1992). The difference with the results reported here may be due to a breed or health status difference, or the fact this study was small, using only five rabbits.…”
Section: Discussionmentioning
confidence: 64%
“…While arterial blood gas values in rabbits have been reported before, these have been from small groups of animals, often as part of anaesthesia studies. Most of these studies have involved sedated or anaesthetised rabbits with variable fraction of inspired oxygen (FiO 2 ) values, or using intermittent positive pressure ventilation, which will influence the values reported (Raemer and others 1983, Egbrink and others 1989, Sakai and others 1999, Allweiler and others 2010) There is only one previous report from non-anaesthetised New Zealand laboratory rabbits, which produced mean values of 102 mm Hg which is higher than the values reported here (Barzago and others 1992). The difference with the results reported here may be due to a breed or health status difference, or the fact this study was small, using only five rabbits.…”
Section: Discussionmentioning
confidence: 64%
“…Tal fato não constituiu surpresa, visto que este parâmetro tem relação direta com a porcentagem de O2 inspirado (CORTOPASSI et al, 2002). Na literatura consultada, os valores normais para a PaO2 em coelhos são de 85 a 91mmHg, 100 a 137mmHg; 140 a 169mmHg, 160 a 217mmHg e 228 a 304mmHg, para as FiO2 de 0,1; 0,4; 0,6; 0,8 e 1,0, respectivamente (BARZAGO et al, 1992;HARCOURT, 2002;JEFFERSON et al, 2002;QUESENBERRY & CARPENTER, 2004;EGI et al, 2007).…”
Section: Esses Resultados Foram Semelhantes Aos Observadosunclassified
“…A PAO2 máxima considerada fisiológica é de 110mmHg para animais respirando ar ambiente, ou seja, contendo 21% de O2 (BARZAGO et al, 1992). Dessa forma, somente as médias do G20 permaneceram abaixo desse valor, enquanto que no restante dos grupos foram observados valores maiores, uma vez que a PAO2 é dependente da FiO2.…”
Section: Esses Resultados Foram Semelhantes Aos Observadosunclassified
“…Os valores de PaCO 2 considerados normais para coelhos variam entre 20 e 46mmHg (Barzago et al, 1992). Neste estudo, todos os animais apresentaram hipercapnia em todos os tempos avaliados, inclusive na avaliação da PaCO 2 basal (Fig.…”
Section: Resultsunclassified
“…(Forster et al, 1980;Chang et al, 2009) A PaO 2 demonstra o balanço entre a quantidade de oxigênio fornecida pela ventilação e o quanto é transferido dos alvéolos para os capilares (Amaral et al, 1992). O valor estimando da PaO 2 em coelhos respirando ar ambiente é 90mmHg (Barzago et al, 1992 A autorregulação da PIC é a ocorrência de mecanismos para manter constantes os componentes da cavidade craniana (parênquima encefálico, LCE e sangue) e controlar o FSC quando a PAM estiver entre 50-150mmHg (Dewey e Fletcher, 2016). Outro mecanismo para a autorregulação da PIC é a química (Carlotti et al, 1998), que se baseia na capacidade de resposta direta da vasculatura cerebral quando houver variação na pressão parcial de dióxido de carbono no sangue arterial (PaCO 2 ).…”
Section: Resultsunclassified