Monitoring of Aromatic Amine Exposures in Workers at a Chemical Plant With a Known Bladder Cancer Excess

Abstract

The adduct data suggest that, among current workers, o-toluidine exposure substantially exceeds aniline exposure and that 4-ABP exposure, if it occurs at all, is not widespread. These data support the conclusion that occupational exposure to o-toluidine is the most likely causal agent of the bladder cancer excess observed among workers in the rubber chemicals department of the plant under study, although exposures to aniline and 4-ABP cannot be ruled out.

Health hazard evaluation report: evaluation of exposures and health at a specialty chemicals plant - West Virginia.

“…Many are classified as skin and eye irritants, and some have adverse reproductive effects, while others may be carcinogens [NIOSH 2010]. For example, aromatic amines have been linked to bladder cancer [Ward et al 1996] while solvent inhalation has been linked to neurotoxicity [Beningus et al 2007].…”

The effect of zinc rich diet to the cytokine profile in the Rat Bladder on cigarette smoke exposure

“…Bazı epidemiyolojik çalışmalar-da sigara içiminin mesane kanseri gelişimi riskini 2-4 kat arttırdığı gösterilmiştir (9). Sigara dumanındaki mesane kanserlerine neden olan en önemli etken aromatik aminlerin N-Nitroso bileşikleri (NOCs) olduğu bilinmesine rağmen kanserojen mekanizma tam olarak anlaşılama-mıştır (10,11). Bölgeler arasında farklılıklar olmakla beraber erkeklerde tüm kanser türleri-nin %4,5'unu ve kadınlarda %1,5'unu oluştu-ran mesane kanseri üriner sistemin en sık görü-len kanserlerinden biridir (12).…”

Perspectives on the chemical etiology of breast cancer.

“…Several polycyclic aromatic amines, such as benzidine, 4-aminobiphenyl, and β-naphthylamine, have been classified by the International Agency for Research on Cancer as known human carcinogens. Epidemiologic studies have suggested that monocyclic aromatic amines such as o-toluidine (2-methylaniline) and 4-chloro-o-toluidine are also human carcinogens (107,108). Comprehensive animal bioassays have determined that many aromatic amines are rodent carcinogens producing tumors at various sites including the mammary gland (109).…”