Monitoring of Antibiotic Residues in Aquatic Products in Urban and Rural Areas of Vietnam

Uchida, Kôtarô; Konishi, Yoshimasa; Harada, Kaoru; Okihashi, Masahiro; Yamaguchi, Takahiro; Ngoc, Mai Hoang; Bui, Long Thi; Nguyen, Thinh D.; Nguyen, Phuc Do; Khong, Diep Thi; Tran, Hoa; Nguyen, Thang Nam; Le, Ha Viet; Chau, Vien Van; Dao, Khanh Thi Van; Nguyen, Hue Thi Ngoc; Kajimura, K.; Kumeda, Yuko; Pham, Khanh Tran; Pham, Khai Ngoc; Bui, Chien Trong; Vien, Mai Quang; Le, Ninh Hoang; Dang, Chinh Van; Hirata, Kazumasa; Yamamoto, Yoshimasa

doi:10.1021/acs.jafc.6b00091

Cited by 66 publications

(23 citation statements)

References 22 publications

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“…(100%). This result is in line with a previous survey of shrimps from local markets in the Red River and Mekong Delta regions of Vietnam (13.0% and 33.3%, respectively) (Pham et al, 2015), but higher than previous results reported from the Vietnamese provinces of HCMC, Thai Binh and Nha Trang (8.8, 1.8 and 3.2%, respectively) (Uchida et al, 2016). However, we were only able to establish the identity of the antimicrobial residue in 4 of 9 samples that tested positive by a bacterial inhibition test.…”

Section: Discussionsupporting

confidence: 92%

Antimicrobial residues, non-typhoidal Salmonella, Vibrio spp. and associated microbiological hazards in retail shrimps purchased in Ho Chi Minh city (Vietnam)

et al. 2020

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We investigated antimicrobial residues, non-typhoidal Salmonella (NTS), Vibrio spp. and their associated antimicrobial resistance (AMR), in shrimps locally purchased in Ho Chi Minh City (Vietnam). In addition, we investigated the relationship between AMR in NTS, Vibrio spp. and antimicrobial residue in the same sample. A total of 40 samples of shrimp heads/shells from different retail sources was cultured using ISO 6579–1:2017 (NTS) and ISO/TS 21872–1:2007 (Vibrio spp.). Phenotypic antimicrobial susceptibility was investigated using Vitek (NTS, 34 antimicrobials) and disk diffusion (Vibrio spp., 12 antimicrobials). A total of 9 (22.5%) samples contained antimicrobial residue, including tetracyclines, fluoroquinolones, sulfonamides and macrolides (in 7.5%, 7.5%, 2.5% and 2.5% of samples, respectively). Shrimp samples from supermarkets had a higher prevalence of antimicrobial residue than those purchased in street markets (50% vs. 13.3%) (p = 0.049). A total of 30 (75%) samples were contaminated with NTS. All samples contained Vibrio spp., with V. parahaemolyticus being most common (87.5% samples). A total of 58.9% NTS isolates were multidrug resistant. With regards to the highest priority, critically important antimicrobials, the highest resistance corresponded to quinolones (14.4–47.8%), followed by 3rd and 4th generation cephalosporins (3.3–7.8%). Vibrio spp. isolates were characterised by their high resistance against ampicillin (82.7%) and 3rd generation cephalosporins (8.3–16.5%). Extended Spectrum Beta-Lactamase (ESBL) activity was detected in 28.1% V. parahaemolyticus isolates. Half of ESBL-positive V. parahaemolyticus strains harboured blaCTX-M1. We found an association between the presence of residues and the number of resistances for NTS (p = 0.075) and Vibrio spp. isolates (p = 0.093) from the same sample. These findings suggest that the presence of residues may contribute to the selection of AMR in foodborne pathogens in shrimps. Authorities should strengthen policies aiming at restricting inappropriate antimicrobial usage in shrimp farming, and step up monitoring of antimicrobial residues and food-borne pathogens at retail in Vietnam.

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Section: Discussionsupporting

confidence: 92%

Antimicrobial residues, non-typhoidal Salmonella, Vibrio spp. and associated microbiological hazards in retail shrimps purchased in Ho Chi Minh city (Vietnam)

et al. 2020

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“…Enrofloxacin was most prevalent antimicrobial, which was detected in 13.4 and 7.5% of fish and shrimp in Ho Chi Minh city, respectively. Fish was not contaminated with oxolinic acid, while shrimp was not contaminated with e Modified by the data described in Uchida et al (2016). Chicken, pork, and beef include meat and internal organs such as heart, river, etc.…”

Section: Residual Antimicrobial In Various Foods and Environmental Wamentioning

confidence: 99%

Prevalence of extended-spectrum β-lactamase-producing Escherichia coli and residual antimicrobials in the environment in Vietnam

Yamasaki

Vien

et al. 2017

Anim. Health. Res. Rev.

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Emergence and spread of antimicrobial-resistant bacteria, including extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, have become serious problems worldwide. Recent studies conducted in Vietnam revealed that ESBL-producing E. coli are widely distributed in food animals and people. CTX-M-9 and CTX-M-1 are the most prevalent β-lactamases among the identified ESBLs. Furthermore, most of the ESBL-producing E. coli isolates were multi-drug resistant. Residual antimicrobials such as sulfamethoxazole, trimethoprim, sulfadimidine, cephalexin, and sulfadiazine were also detected at a high level in both animal meats and environmental water collected from several cities, including Ho Chi Minh city and Can Tho city. These recent studies indicated that improper use of antimicrobials in animal-originated food production might contribute to the emergence and high prevalence of ESBL-producing E. coli in Vietnam. Although clonal ESBL-producing E. coli was not identified, CTX-M-55 gene-carrying plasmids with similar sizes (105-139 kb) have been commonly detected in the ESBL-producing E. coli strains isolated from various food animals and human beings. This finding strongly suggests that horizontal transfer of the CTX-M plasmid among various E. coli strains played a critical role in the emergence and high prevalence of ESBL-producing E. coli in Vietnam.

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“…Yang et al 9 reported residues of quinolones in fish in Guangzhou. Antibiotics were detected in aquatic products of Ningbo, Beijing, Shanghai 10 , India 11 , Vietnam 12 , South Carolina, and Georgia 13 . China is not only a major producer of antibiotics but also a major user 14 , 15 .…”

Section: Introductionmentioning

confidence: 99%

Occurrence, distribution, and health risk assessment of quinolone antibiotics in water, sediment, and fish species of Qingshitan reservoir, South China

Huang

et al. 2020

Sci Rep

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The residual antibiotics in the environment have lately caused widespread concerns. However, little information is available on the antibiotic bioaccumulation and its health risk in drinking water resources of South China. Therefore, the occurrence, distribution, and health risk of four quinolone antibiotics including ofloxacin (OFX), norfloxacin (NOR), ciprofloxacin (CIP), and enrofloxacin (ENR) in the Qingshitan reservoir using high-performance liquid chromatography were investigated. Results revealed that the concentrations in water, sediment, and edible fish ranged from 3.49–660.13 ng/L, 1.03–722.18 μg/kg, and 6.73–968.66 μg/kg, respectively. The ecological risk assessment via the risk quotient (RQ) method showed that the values in sediment were all greater than 1, posing a high risk to the environment. The health risk index of water samples was at the maximum acceptable level, with OFX at the top while the rest were at the medium risk level. The main edible fish kinds of the reservoir had high dietary safety and the highest contaminations were found in carnivorous feeding habits and demersal habitat fishes with OFX as the highest magnitude. Source identification and correlation analysis using SPSS showed significant relationships between NOR with pH and turbidity (in water), as well as total phosphor (TP) and total organic carbon (TOC) in sediment. NOR was the highest in sediment which mostly sourced from livestock wastewater, croplands irrigation drain water, and stormwater. Correlations between CIP and ENR with TP were significant, while OFX was positively associated with total nitrogen (TN) which mainly originated from urban sewage as well as directly dosed drugs in fish farms. In conclusion, our results are of great significance for ensuring the safety of drinking water and aquatic products in this region.

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Monitoring of Antibiotic Residues in Aquatic Products in Urban and Rural Areas of Vietnam

Cited by 66 publications

References 22 publications

Antimicrobial residues, non-typhoidal Salmonella, Vibrio spp. and associated microbiological hazards in retail shrimps purchased in Ho Chi Minh city (Vietnam)

Antimicrobial residues, non-typhoidal Salmonella, Vibrio spp. and associated microbiological hazards in retail shrimps purchased in Ho Chi Minh city (Vietnam)

Prevalence of extended-spectrum β-lactamase-producing Escherichia coli and residual antimicrobials in the environment in Vietnam

Occurrence, distribution, and health risk assessment of quinolone antibiotics in water, sediment, and fish species of Qingshitan reservoir, South China

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