Monitoring Occurrence of Liver-Related Events and Survival by Transient Elastography in Patients With Nonalcoholic Fatty Liver Disease and Compensated Advanced Chronic Liver Disease

Petta, Salvatore; Sebastiani, Giada; Viganò, Mauro; Ampuero, Javier; Wong, Vincent Wai‐Sun; Boursier, Jérôme; Berzigotti, Annalisa; Bugianesi, Elisabetta; Fracanzani, Anna Ludovica; Cammà, Calogero; Enea, Marco; Grottes, Marraud des; Marco, V. Di; Younes, Ramy; Keyrouz, Aline; Mazzola, S; Mendoza, Yuly; Pennisi, Grazia; Romero–Gómez, Manuel; Craxı̀, Antonio; Lédinghen, Victor de

doi:10.1016/j.cgh.2020.06.045

Cited by 117 publications

(94 citation statements)

References 30 publications

(27 reference statements)

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“…(18) More recently, similar results were obtained from patients with nonviral chronic liver disease. (19,20) Liver stiffness measurement by means of acoustic radiation force impulse (ARFI) imaging was a more recent addition to the elastography market. (21) Several studies have shown its clinical applicability and comparability to histology and other noninvasive methods, including TE, for the assessment of liver fibrosis.…”

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confidence: 99%

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Point Shear-Wave Elastography Using Acoustic Radiation Force Impulse Imaging for the Prediction of Liver-Related Events in Patients With Chronic Viral Hepatitis

Sampere

Vermehren

Mücke

et al. 2021

Hepatology Communications

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Chronic viral hepatitis is associated with substantial morbidity and mortality worldwide. The aim of our study was to assess the ability of point shear‐wave elastography (pSWE) using acoustic radiation force impulse imaging for the prediction of the following liver‐related events (LREs): new diagnosis of HCC, liver transplantation, or liver‐related death (hepatic decompensation was not included as an LRE). pSWE was performed at study inclusion and compared with liver histology, transient elastography (TE), and serologic biomarkers (aspartate aminotransferase to platelet ratio index, Fibrosis‐4, FibroTest). The performance of pSWE and TE to predict LREs was assessed by calculating the area under the receiver operating characteristic curve and a Cox proportional‐hazards regression model. A total of 254 patients with a median follow‐up of 78 months were included in the study. LRE occurred in 28 patients (11%) during follow‐up. In both patients with hepatitis B virus and hepatitis C virus (HCV), pSWE showed significant correlations with noninvasive tests and TE, and median pSWE and TE values were significantly different between patients with LREs and patients without LREs (both P < 0.0001). In patients with HCV, the area under the receiver operating characteristic curve for pSWE and TE to predict LREs were comparable: 0.859 (95% confidence interval [CI], 0.747‐0.969) and 0.852 (95% CI, 0.737‐0.967) (P = 0.93). In Cox regression analysis, pSWE independently predicted LREs in all patients with HCV (hazard ratio, 17.9; 95% CI, 5.21‐61‐17; P < 0.0001) and those who later received direct‐acting antiviral therapy (hazard ratio, 17.11; 95% CI, 3.88‐75.55; P = 0.0002). Conclusion: Our study shows good comparability between pSWE and TE. pSWE is a promising tool for the prediction of LREs in patients with viral hepatitis, particularly those with chronic HCV. Further studies are needed to confirm our data and assess their prognostic value in other liver diseases.

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confidence: 99%

“…( 18 ) More recently, similar results were obtained from patients with nonviral chronic liver disease. ( 19,20 )…”

mentioning

confidence: 99%

Point Shear-Wave Elastography Using Acoustic Radiation Force Impulse Imaging for the Prediction of Liver-Related Events in Patients With Chronic Viral Hepatitis

Sampere

Vermehren

Mücke

et al. 2021

Hepatology Communications

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“…Additional MR analysis of hepatic iron and fat content further increased the predictive capacity of the model. In more than a thousand patients with severe liver fibrosis in the course of NAFLD, the baseline liver stiffness value was strongly associated with the occurrence of both decompensation of liver function and hepatocellular carcinoma, along with liver-related mortality [ 106 ]. Subgroup analysis from the same study performed by Petta et al additionally provided evidence for the prognostic significance of the changes in liver stiffness measurement on TE by at least 20% with respect to those clinical outcomes and, furthermore, overall patient survival.…”

Section: Predictive Role Of Imaging Methods In Patients With Nafldmentioning

confidence: 99%

Usefulness of Different Imaging Modalities in Evaluation of Patients with Non-Alcoholic Fatty Liver Disease

Grąt

Rowiński

2020

Biomedicines

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Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are becoming some of the major health problems in well-developed countries, together with the increasing prevalence of obesity, metabolic syndrome, and all of their systemic complications. As the future prognoses are even more disturbing and point toward further increase in population affected with NAFLD/NASH, there is an urgent need for widely available and reliable diagnostic methods. Consensus on a non-invasive, accurate diagnostic modality for the use in ongoing clinical trials is also required, particularly considering a current lack of any registered drug for the treatment of NAFLD/NASH. The aim of this narrative review was to present current information on methods used to assess liver steatosis and fibrosis. There are several imaging modalities for the assessment of hepatic steatosis ranging from simple density analysis by computed tomography or conventional B-mode ultrasound to magnetic resonance spectroscopy (MRS), magnetic resonance imaging proton density fat fraction (MRI-PDFF) or controlled attenuation parameter (CAP). Fibrosis stage can be assessed by magnetic resonance elastography (MRE) or different ultrasound-based techniques: transient elastography (TE), shear-wave elastography (SWE) and acoustic radiation force impulse (ARFI). Although all of these methods have been validated against liver biopsy as the reference standard and provided good accuracy, the MRS and MRI-PDFF currently outperform other methods in terms of diagnosis of steatosis, and MRE in terms of evaluation of fibrosis.

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“…Although most noninvasive techniques were developed to detect advanced (F3) fibrosis, because it predicts liver-related outcomes, 3 identification of at-risk or fibrotic NASH (a composite of NASH þ NAFLD activity score 4 þ F2 fibrosis) has gained attention for the recruitment of patients in clinical trials. This histologic…”

Section: Conflicts Of Interestmentioning

confidence: 99%

Use of FibroScan–AST Score to Stratify High-Risk Nonalcoholic Steatohepatitis in US Veterans

Puri

Jain

Fuchs

2020

Clinical Gastroenterology and Hepatology

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US Veterans have a higher prevalence of nonalcoholic steatohepatitis (NASH) compared with the general US population. 1 Recently, vibration-controlled transient elastography (VCTE, FibroScan) proved valuable in evaluating hepatic steatosis and fibrosis in adolescents, and monitoring for liver-related events and survival in patients with nonalcoholic fatty liver disease (NAFLD)-related compensated advanced liver disease. 2,3 Validated noninvasive assessments are required as a surrogate to liver biopsy in stratifying patients with NASH, 4 particularly those at the highest risk for disease progression and liver-related outcomes (ie, NAFLD Activity Score [NAS] 4 and stage 2 fibrosis [F2]). 5 The FibroScan-AST (FAST) score combines VCTE liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) with aspartate aminotransferase (AST) that effectively risk stratifies patients with progressive NASH. 6 The utility of this test in the Veterans population is unknown. We examined the diagnostic accuracy of FAST score in the real world clinical setting to stratify subjects with low-and highrisk NASH. We performed a cross-sectional study from a prospectively evaluated cohort of suspected NAFLD in a tertiary care Veterans Affairs facility from January 1, 2017 to May 30, 2019. Of 448 Veterans, 249 were excluded (coexistent other liver diseases ¼ 170, biopsy and VCTE >12 months apart ¼ 58, VCTE failure ¼ 19, and FAST score unavailable ¼ 2). Thus, 199 US Veterans had AST, LSM by VCTE, CAP, and liver histology on an average within 3 months (0-12 months). A trained nurse did VCTE to measure LSM and CAP. Demographic, clinical, laboratory, and histologic data were collected. The NAS score and fibrosis stage, and NASH were defined using NASH Clinical Research Network 5 and Fatty Liver Inhibition of Progression criteria 4 , respectively. The FAST score was derived as recently

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Monitoring Occurrence of Liver-Related Events and Survival by Transient Elastography in Patients With Nonalcoholic Fatty Liver Disease and Compensated Advanced Chronic Liver Disease

Cited by 117 publications

References 30 publications

Point Shear-Wave Elastography Using Acoustic Radiation Force Impulse Imaging for the Prediction of Liver-Related Events in Patients With Chronic Viral Hepatitis

Point Shear-Wave Elastography Using Acoustic Radiation Force Impulse Imaging for the Prediction of Liver-Related Events in Patients With Chronic Viral Hepatitis

Usefulness of Different Imaging Modalities in Evaluation of Patients with Non-Alcoholic Fatty Liver Disease

Use of FibroScan–AST Score to Stratify High-Risk Nonalcoholic Steatohepatitis in US Veterans

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