Monitoring innate immune cell dynamics in the glioma microenvironment by magnetic resonance imaging and multiphoton microscopy (MR-MPM)

Karimian-Jazi, Kianush; Münch, Philipp; Alexander, A.; Fischer, Manuel; Pfleiderer, Kira; Piechutta, Manuel; Karreman, Matthia A.; Solecki, Gergely; Berghoff, Anna Sophie; Friedrich, Mirco; Deumelandt, Katrin; Kurz, Felix T.; Wick, Wolfgang; Heiland, Sabine; Bendszus, Martin; Winkler, Frank; Platten, Michael; Breckwoldt, Michael O.

doi:10.7150/thno.38659

Cited by 33 publications

(24 citation statements)

References 45 publications

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“…They also demonstrated the efficacy of anti-VEGFA blockades for prohibiting GAMs infiltration [ 115 ]. Karimian-Jazi et al dissected the single steps of nanoparticle (NP) uptake by blood-borne monocytes that give rise to GAMs by magnetic resonance imaging and multiphoton microscopy (MR-MPM), allowing for innate immune cell tracking by MRI and multiphoton microscopy in the same animal to longitudinally investigate innate immune cell dynamics in the TME [ 116 ].…”

Section: The Next Stepmentioning

confidence: 99%

Macrophages/Microglia in the Glioblastoma Tumor Microenvironment

Chen

2021

IJMS

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The complex interaction between glioblastoma and its microenvironment has been recognized for decades. Among various immune profiles, the major population is tumor-associated macrophage, with microglia as its localized homolog. The present definition of such myeloid cells is based on a series of cell markers. These good sentinel cells experience significant changes, facilitating glioblastoma development and protecting it from therapeutic treatments. Huge, complicated mechanisms are involved during the overall processes. A lot of effort has been dedicated to crack the mysterious codes in macrophage/microglia recruiting, activating, reprogramming, and functioning. We have made our path. With more and more key factors identified, a lot of new therapeutic methods could be explored to break the ominous loop, to enhance tumor sensitivity to treatments, and to improve the prognosis of glioblastoma patients. However, it might be a synergistic system rather than a series of clear, stepwise events. There are still significant challenges before the light of truth can shine onto the field. Here, we summarize recent advances in this field, reviewing the path we have been on and where we are now.

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Section: The Next Stepmentioning

confidence: 99%

Macrophages/Microglia in the Glioblastoma Tumor Microenvironment

Chen

2021

IJMS

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“…Depending on the choice of the lineage-tracing mouse model and/or other labeling strategies, a plethora of cell types known to be involved in neuropathology can be visualized by IVM, including MG and other immune cells, neurons, astrocytes, oligodendrocytes, and (peri)vascular cells, while simultaneously monitoring the disease course by MRI. Future studies could even incorporate functional MRI or molecular MRI protocols to further extend the multimodal platform, similar to the imaging of iron oxide nanoparticle uptake in the TME by two-photon IVM and MRI ( Karimian-Jazi et al., 2020 ). Lastly, we also demonstrate the critical insights gained from applying data science tools initially developed for single-cell RNA sequencing data, which facilitated the deep interrogation of large IVM datasets.…”

Section: Discussionmentioning

confidence: 99%

Multimodal imaging of the dynamic brain tumor microenvironment during glioblastoma progression and in response to treatment

et al. 2022

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“…Although some SPIONs were approved for clinical use as pure T2 contrast agents, they have been gradually withdrawn from clinical application in recent years, mainly due to shortcomings of poor imaging specificity (such as confusion with bleeding and calcification) [ 73 ]. Nevertheless, the T2 contrast enhancement of MIONs has been widely used in recent years for image tracking and therapy guidance of the spatiotemporal position of MIONs in vivo, such as the use of T2–weighted MRI to track cells marked by MIONs [ 74 , 75 ].…”

Section: Basis Of Magnetic Nanomaterials Mediated Diagnosis and Therapy Of Cancermentioning

confidence: 99%

Design of Magnetic Nanoplatforms for Cancer Theranostics

et al. 2022

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Cancer is the top cause of death globally. Developing smart nanomedicines that are capable of diagnosis and therapy (theranostics) in one–nanoparticle systems are highly desirable for improving cancer treatment outcomes. The magnetic nanoplatforms are the ideal system for cancer theranostics, because of their diverse physiochemical properties and biological effects. In particular, a biocompatible iron oxide nanoparticle based magnetic nanoplatform can exhibit multiple magnetic–responsive behaviors under an external magnetic field and realize the integration of diagnosis (magnetic resonance imaging, ultrasonic imaging, photoacoustic imaging, etc.) and therapy (magnetic hyperthermia, photothermal therapy, controlled drug delivery and release, etc.) in vivo. Furthermore, due to considerable variation among tumors and individual patients, it is a requirement to design iron oxide nanoplatforms by the coordination of diverse functionalities for efficient and individualized theranostics. In this article, we will present an up–to–date overview on iron oxide nanoplatforms, including both iron oxide nanomaterials and those that can respond to an externally applied magnetic field, with an emphasis on their applications in cancer theranostics.

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Monitoring innate immune cell dynamics in the glioma microenvironment by magnetic resonance imaging and multiphoton microscopy (MR-MPM)

Cited by 33 publications

References 45 publications

Macrophages/Microglia in the Glioblastoma Tumor Microenvironment

Macrophages/Microglia in the Glioblastoma Tumor Microenvironment

Multimodal imaging of the dynamic brain tumor microenvironment during glioblastoma progression and in response to treatment

Design of Magnetic Nanoplatforms for Cancer Theranostics

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