Monitoring gold nanoparticle distribution with high resolution using photo-magnetic imaging

Luk, Alex; Nouizi, Farouk; Marks, Michael Lawrance; Kart, Turkay; Gülşen, Gültekin

doi:10.1117/12.2213852

Cited by 3 publications

(1 citation statement)

References 12 publications

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“…PMI is a noninvasive high-resolution imaging technique that accurately provides tissue optical absorption and overcomes several limitations of conventional diffuse optical imaging techniques. The superior performance of PMI has been proven using numerous simulation and experimental studies [26][27][28][29][30][31]. In PMI, a continuous wave laser is applied to induce a slight increase of temperature in the imaged tissue.…”

Section: Introductionmentioning

confidence: 99%

Multi‐Wavelength Photo‐Magnetic Imaging System for Photothermal Therapy Guidance

et al. 2020

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Background and Objectives: In photothermal therapy, cancerous tissue is treated by the heat generated from absorbed light energy. For effective photothermal therapy, the parameters affecting the induced temperature should be determined before the treatment by modeling the increase in temperature via numerical simulations. However, accurate simulations can only be achieved when utilizing the accurate optical, thermal, and physiological properties of the treated tissue. Here, we propose a multiwavelength photo-magnetic imaging (PMI) technique that provides quantitative and spatially resolved tissue optical absorption maps at any wavelength within the nearinfrared (NIR) window to assist accurate photothermal therapy planning. Study Design/Materials and Methods: The study was conducted using our recently developed multi-wavelength PMI system, which operates at four laser wavelengths (760, 808, 860, and 980 nm). An agar tissue-simulating phantom containing water, lipid, and ink was illuminated using these wavelengths, and the slight internal laserinduced temperature rise was measured using magnetic resonance thermometry (MRT). The phantom optical absorption was recovered at the used wavelengths using our dedicated PMI image reconstruction algorithm. These absorption maps were then used to resolve the concentration of the tissue chromophores, and thus deduce its optical absorption spectrum in the NIR region based on the Beer-Lambert law. Results: The optical absorption of the phantom was successfully recovered at the used four wavelengths with an average error of~1.9%. The recovered absorption coefficient was then used to simulate temperature variations inside the phantom. A comparison between the modeled temperature maps and the MRT measured ones showed that these maps are in a good agreement with an average pseudo R 2 statistic of 0.992. These absorption values were used to successfully recover the concentration of the used chromophores. Finally, these concentrations are used to accurately calculate the total absorption spectrum of the phantom in the NIR spectral window with an average error as low as~2.3%. Conclusions:Multi-wavelength PMI demonstrated a great ability to assess the distribution of tissue chromophores, thus providing its total absorption at any wavelength within the NIR spectral range. Therefore, applications of photothermal therapy applied at NIR wavelengths can benefit from the absorption spectrum recovered by PMI to determine important parameters such as laser power as well as the laser exposure time needed to attain a specific increase in temperature prior to treatment. Lasers Surg. Med.

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Section: Introductionmentioning

confidence: 99%

Multi‐Wavelength Photo‐Magnetic Imaging System for Photothermal Therapy Guidance

et al. 2020

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Improved Method of Study on the Photothermal Effect of Plasmonic Nanoparticles by Dynamic IR Thermography

et al. 2018

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Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging

Algarawi

Erkol

Luk

et al. 2020

Biomed. Opt. Express

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Photo-magnetic imaging (PMI) is an emerging optical imaging modality that showed great performance on providing absorption maps with high resolution and quantitative accuracy. As a multi-modality technology, PMI warms up the imaged object using a near infrared laser while temperature variation is measured using magnetic resonance imaging. By probing tissue at multiple wavelengths, concentration of the main tissue chromophores such as oxy- and deoxy-hemoglobin, lipid, and water are obtained then used to derive functional parameters such as total hemoglobin concentration and relative oxygen saturation. In this paper, we present a multi-wavelength PMI system that was custom-built to host five different laser wavelengths. After recovering the high-resolution absorption maps, a least-squared minimization process was used to resolve the different chromophore concentration. The performance of the system was experimentally tested on a phantom with two different dyes. Their concentrations were successfully assessed with high spatial resolution and average accuracy of nearly 80%.

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Monitoring gold nanoparticle distribution with high resolution using photo-magnetic imaging

Cited by 3 publications

References 12 publications

Multi‐Wavelength Photo‐Magnetic Imaging System for Photothermal Therapy Guidance

Multi‐Wavelength Photo‐Magnetic Imaging System for Photothermal Therapy Guidance

Improved Method of Study on the Photothermal Effect of Plasmonic Nanoparticles by Dynamic IR Thermography

Resolving tissue chromophore concentration at MRI resolution using multi-wavelength photo-magnetic imaging

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