Monitoring cortical hemodynamic changes after sumatriptan injection during migraine attack by near-infrared spectroscopy

Watanabe, Yuka; Tanaka, Hideaki; Dan, Ippeita; Sakurai, Kunihiko; Kimoto, Kazuhito; Takashima, Ryotaro; Hirata, Koichi

doi:10.1016/j.neures.2010.09.003

Cited by 16 publications

(13 citation statements)

References 38 publications

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“…A confounding effect of cutaneous blood flow on the NIRS-derived cerebral oxygenation seemed to have no effect on cerebral [HHb] as shown in a previous study (26). In addition, it has also been shown that sumatriptan induces both intra- and extracranial vasoconstriction (16). Thus, we argue that the NIRS findings observed in migraineurs do reflect impaired cerebrovascular responses.…”

Section: Discussionmentioning

confidence: 99%

“…Near-Infrared Spectroscopy (NIRS), evaluating a regional balance between microvascular O 2 delivery and utilization, has been applied to monitor cerebral hemodynamics (15). Using NIRS, a reduction of cortical oxyhaemoglobin ([O 2 Hb]) after sumatriptan injection has been reported during a migraine attack (16). Also, NIRS measurements performed interictally on migraineurs have demonstrated abnormal cerebrovascular responses e.g., to hypercapnia (17).…”

Section: Introductionmentioning

confidence: 99%

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Tooth Clenching Induces Abnormal Cerebrovascular Responses in Migraineurs

et al. 2018

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Prevalence of masticatory parafunctions, such as tooth clenching and grinding, is higher among migraineurs than non-migraineurs, and masticatory dysfunctions may aggravate migraine. Migraine predisposes to cerebrovascular disturbances, possibly due to impaired autonomic vasoregulation, and sensitization of the trigeminovascular system. The relationships between clenching, migraine, and cerebral circulation are poorly understood. We used Near-Infrared Spectroscopy to investigate bilateral relative oxy- (%Δ[O2Hb]), deoxy- (%Δ[HHb]), and total (%Δ[tHb]) hemoglobin concentration changes in prefrontal cortex induced by maximal tooth clenching in twelve headache-free migraineurs and fourteen control subjects. From the start of the test, migraineurs showed a greater relative increase in right-side %Δ[HHb] than controls, who showed varying reactions, and right-side increase in %Δ[tHb] was also greater in migraineurs (p < 0.001 and p < 0.05, respectively, time-group interactions, Linear mixed models). With multivariate regression model, migraine predicted the magnitude of maximal blood pressure increases, associated in migraineurs with mood scores and an intensity of both headache and painful signs of temporomandibular disorders (pTMD). Although changes in circulatory parameters predicted maximal NIRS responses, the between-group differences in the right-side NIRS findings remained significant after adjusting them for systolic blood pressure and heart rate. A family history of migraine, reported by all migraineurs and four controls, also predicted maximal increases in both %Δ[HHb] and %Δ[tHb]. Presence of pTMD, revealed in clinical oral examination in eight migraineurs and eight controls, was related to maximal %Δ[HHb] increase only in controls. To conclude, the greater prefrontal right-side increases in cerebral %Δ[HHb] and %Δ[tHb] may reflect disturbance of the tooth clenching-related cerebral (de)oxygenation based on impaired reactivity and abnormal microcirculation processes in migraineurs. This finding may have an impact in migraine pathophysiology and help to explain the deleterious effect of masticatory dysfunctions in migraine patients. However, the role of tooth clenching as a migraine trigger calls for further studies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tooth Clenching Induces Abnormal Cerebrovascular Responses in Migraineurs

et al. 2018

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“…None of the 164 subjects who “mixed triptans” at least once experienced a serious adverse event clearly related to administration of those drugs. Within the 24 hours following administration of the second triptan, 7 subjects whose migraine symptoms failed to respond to this self‐administered therapy sought treatment at an emergency department, 3 physician's office, 3 or urgent care center; 1 in no case did review of the related medical records indicate any evidence of cardiovascular or cerebrovascular morbidity or of other morbidity directly attributable to the triptans.…”

Section: Resultsmentioning

confidence: 99%

“…The triptans are agonists at 5HT‐1B receptors and consequently possess the potential for causing vasoconstriction. While there is abundant evidence that these drugs exert a vasoconstrictive effect upon scalp and cerebral vessels, that effect is less prominent in the coronary bed 2,3 . When used as indicated for the treatment of acute migraine headache, the triptans appear to be exceedingly safe medications.…”

Section: Discussionmentioning

confidence: 99%

“Mixing Triptans”: Patient Satisfaction

Rothrock

Morey

2011

Headache

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“…Interestingly, Tsujii et al (2010) were able show the difference in cerebral oxygenation following sedating and non-sedating anti-histamine variants, with reductions in CBF only being observed for the sedating variety. In adults, NIRS has been used to show decreased frontal lobe oxygenation following sumatriptan administration in migraine sufferers (Watanabe et al, 2011) and also following the vasopressor agent phenylephrine, wherein the technique has been instrumental in providing evidence in support of sympathetic regulation of cerebral circulation (Brassard et al, 2010; Ogoh et al, 2011). Conversely, increased frontal CBF has also been demonstrated following the vasodilator vinpocetine in stroke patients (Bonoczk et al, 2002).…”

Section: Validity Of Nirs Examinationsmentioning

confidence: 99%

The application of near infrared spectroscopy in nutritional intervention studies

Jackson¹,

Kennedy²

2013

Front. Hum. Neurosci.

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Functional near infrared spectroscopy (NIRS) is a non-invasive optical imaging technique used to monitor cerebral blood flow (CBF) and by proxy neuronal activation. The use of NIRS in nutritional intervention studies is a relatively novel application of this technique, with only a small, but growing, number of trials published to date. These trials—in which the effects on CBF following administration of dietary components such as caffeine, polyphenols and omega-3 polyunsaturated fatty acids are assessed—have successfully demonstrated NIRS as a sensitive measure of change in hemodynamic response during cognitive tasks in both acute and chronic treatment intervention paradigms. The existent research in this area has been limited by the constraints of the technique itself however advancements in the measurement technology, paired with studies endeavoring increased sophistication in number and locations of channels over the head should render the use of NIRS in nutritional interventions particularly valuable in advancing our understanding of the effects of nutrients and dietary components on the brain.

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Monitoring cortical hemodynamic changes after sumatriptan injection during migraine attack by near-infrared spectroscopy

Cited by 16 publications

References 38 publications

Tooth Clenching Induces Abnormal Cerebrovascular Responses in Migraineurs

Tooth Clenching Induces Abnormal Cerebrovascular Responses in Migraineurs

“Mixing Triptans”: Patient Satisfaction

The application of near infrared spectroscopy in nutritional intervention studies

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