Monitoring Cerebral Oxygenation: Experimental Studies and Preliminary Clinical Results of Continuous Monitoring of Cerebrospinal Fluid and Brain Tissue Oxygen Tension

Maas, Andrew I. R.; Fleckenstein, W.; Jong, D. A. de; Santbrink, Henk van

doi:10.1007/978-3-7091-9302-0_9

Cited by 105 publications

(98 citation statements)

References 9 publications

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“…The Clark-type LX-sensors used in this study have a diameter of 0.45 mm, a pO 2 -sensitive sensor length of 5 mm and a surface area for measuring pO 2 mentioned in the literature between 7.1 and 15 mm 2 [4,13]. The NT sensor used in this report integrates three optical sensors (pH sensor is anchored to the tip of the sensor, followed by pCO 2 -and pO 2 -sensor) and a thermocouple in one catheter probe.…”

Section: Methodsmentioning

confidence: 99%

Brain oxygen monitoring: in-vitro accuracy, long-term drift and response-time of Licox- and Neurotrend sensors

Hoelper

Alessandri

Heimann

et al. 2005

Acta Neurochir (Wien)

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SummaryBackground. Oxygen tension sensors have been used to monitor tissue oxygenation in human brain for several years. The working principals of the most frequently used sensors, the Licox (LX) and Neurotrend (NT), are different, and they have never been validated independently for correct measurement in vitro. Therefore, we tried to clarify if the two currently available sensors provide sufficient accuracy and stability.Method. 12 LX oxygen tension sensors and NT sensors were placed into a liquid-filled tonometer chamber. The solution was kept at 37 AE 0.2 C and equilibrated with five calibration gases containing different O 2 -and CO 2 -concentrations. After equilibration, readings were taken for each gas concentration (accuracy test). Afterwards, the sensors were left in 3% O 2 and 9% CO 2 and readings were taken after 24, 48, 72, 96 and 120 hours (drift test). Thereafter, a 90% response time test was performed transferring sensors from 1% to 5% oxygen concentration and back, using pre-equilibrated tonometers.Findings. All Licox oxygen probes [12] were used for this study. Two of 14 Neurotrend sensors did not calibrate, revealing a failure rate of 14% for NT. Oxygen tension during the accuracy test was measured as follows: 1% O 2 (7.1 mmHg): LX 6.5 AE 0.4, NT 5.3 AE 2.3 mmHg, 2% O 2 (14.2 mmHg): LX 12.9 AE 0.6, NT 12.1 AE 2.2 mmHg, 3% O 2 (21.4 mmHg): LX 19.8 AE 0.7, NT 19.4 AE 2.4 mmHg, 5% O 2 (35.8 mmHg): LX 33.4 AE 1.0 mmHg, NT 33.5 AE 2.9 mmHg, 8% O 2 (57.0 mmHg): 53.8 AE 1.5, NT 53.6 AE 3.3 mmHg. After 120 hours in 3% O 2 (21 mmHg), LX measured 19.8 AE 1.9 mmHg, NT 17.9 AE 4.7 mmHg. 90% response time from 1% to 5%=5% to 1% oxygen concentration was 129 AE 27=174 AE 26 sec for LX, 55 AE 19=98 AE 39 sec for NT.Conclusions. Both systems are measuring oxygen tension sufficiently, but more accurately with LX probes. NT sensors read significantly lower pO 2 in 1% O 2 and show an increasing deviation with higher oxygen concentrations which was due to two of twelve probes. A slight drift towards lower oxygen tension readings for both sensors but more pronounced for the NT does not impair long-term use. NT measures pCO 2 and pH very accurately.

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Section: Methodsmentioning

confidence: 99%

Brain oxygen monitoring: in-vitro accuracy, long-term drift and response-time of Licox- and Neurotrend sensors

Hoelper

Alessandri

Heimann

et al. 2005

Acta Neurochir (Wien)

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“…[11][12][13] Several experimental studies have shown that the continuous measurement of the PbrO 2 in animals significantly reflects changes in blood oxygenation and ventilatory changes and changes in ICP and CPP. 14,15 Clinical experience with PbrO 2 monitoring has mainly been gained from patients with severe brain injury. 8,11,13,16 -18 We therefore extended our treatment procedures to multimodal, bilateral monitoring.…”

mentioning

confidence: 99%

Multimodal Online Monitoring in Middle Cerebral Artery Territory Stroke

Steiner

Pilz²,

Schellinger³

et al. 2001

Stroke

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“…Normal pbtO2 values based on Licox technology are around 25 to 30mmHg, based on animal research [119]. This was confirmed in patients with normal ICP and CPP [13,256].…”

Section: Definition Of Normal and Pathological Values -A Complex Taskmentioning

confidence: 76%

Systematic and Comprehensive Literature Review of Publications on Direct Cerebral Oxygenation Monitoring

Lang

Jaeger²

2013

TOCCMJ

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This review has been compiled to assess publications related to the clinical application of direct cerebral tissue oxygenation (pbtO2) monitoring published in international, peer-reviewed scientific journals, or major meeting reports published as journal supplements. Its goal was to extract relevant, i.e. positive and negative, information on indications, clinical application, safety issues and impact on clinical situations, as well as treatment strategies in neurosurgery, neurosurgical anaesthesiology, neurosurgical intensive care, neurology, and related specialties. For completeness' sake it also presents related basic science research and case reports. This review is an update of its previous edition published elsewhere in 2007. This review reflects publications from 2004 to 2012. Only relevant publications prior to 2004, which explicitly addressed or systematically examined the above issues, are included in this review and are listed in the reference section. Based on 349 citations it is the most comprehensive review available on direct cerebral oxygen monitoring to this date.Keywords: Review, cerebral oxygenation, raumedic, licox, neurotrend, cerebral partial pressure of oxygen, brain tissue oxygenation. METHODSThis review is based on a systematic "Medline" literature search using the following search terms: licox, neurotrend, neurovent, raumedic, brain tissue oxygen, brain tissue oxygenation, cerebral oxygenation, cerebral tissue oxygen, cerebral partial pressure of oxygen, btO2, ptiO2, pti(O)2, ptiO(2), pbrO2, PBr(O2), P(bt)O(2), P(br)O(2), PbrO(2), BTpO2, tP(O2), PbO2, PbtO2, Pbto, PbtO(2).Only few publications were not retrieved using this technique. They were, however, identified through personal communication with scientists in the field, meeting proceedings and reviewer assignments. This strategy provided sufficient certainty that relevant papers have not been missed. Unpublished meeting abstracts and published conference proceedings were excluded for this review expect for few which provided comparative studies between different probes. To address relevant matters, related to specific pbtO2 issues, selected non-peer reviewed papers published in supplements were also used only when no other peer-reviewed information was available. RESULTSThis review is based on a previous review [1]. It is currently based on 349 papers, 274 more papers compared to its previous version in 2007, which warrants the update.

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Monitoring Cerebral Oxygenation: Experimental Studies and Preliminary Clinical Results of Continuous Monitoring of Cerebrospinal Fluid and Brain Tissue Oxygen Tension

Cited by 105 publications

References 9 publications

Brain oxygen monitoring: in-vitro accuracy, long-term drift and response-time of Licox- and Neurotrend sensors

Brain oxygen monitoring: in-vitro accuracy, long-term drift and response-time of Licox- and Neurotrend sensors

Multimodal Online Monitoring in Middle Cerebral Artery Territory Stroke

Systematic and Comprehensive Literature Review of Publications on Direct Cerebral Oxygenation Monitoring

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