Monitoramento De Interações Farmacocinéticas Entre Plantas Medicinais E Fitoterápicos E Os Medicamentos Convencionais Pelo Sistema De Farmacovigilância Brasileiro

Mazzari, Andre L. D. A.; Prieto, José M.

doi:10.14450/2318-9312.v26.e3.a2014.pp193-198

Cited by 7 publications

(8 citation statements)

References 21 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[12][13][14][15][16][17][18] Bornesitol elicits a potent angiotensinconverting enzyme (ACE) inhibition in vitro and molecular docking studies showed that this and other cyclitols bind to the same region of the human ACE, which is a tunnel directed towards the active site, distinct from the binding site of the classical ACE-inhibitors like captopril. 19) Interestingly, bornesitol is the major constituent (7.75 ± 0.78% (w/w)) of a refined dry extract from H. speciosa leaves, standardised according to EMA guideline, 20) which induced a dose-dependent, longlasting reduction in the systolic blood pressure in conscious deoxycorticosterone acetate (DOCA)-salt hypertensive mice. 17) The regulation of herbal medicinal products (HMP) in Brazil is in charge of the Brazilian Health Regulatory Agency (ANVISA), which establishes two types of markers for the quality control of HMP.…”

Section: Introductionmentioning

confidence: 99%

The Cyclitol L-(+)-Bornesitol as an Active Marker for the Cardiovascular Activity of the Brazilian Medicinal Plant <i>Hancornia speciosa</i>

Moreira

Silva

Câmara

et al. 2019

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

The cyclitol bornesitol is the main constituent of the leaves from the antihypertensive medicinal plant Hancornia speciosa. This study aimed to investigate the ability of bornesitol to reduce blood pressure and its mechanism of action. Normotensive Wistar rats were divided into control group and bornesitol groups treated intravenously with bornesitol (0.1, 1.0 and 3.0 mg/kg). Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded in non-anesthetized awake animals. Nitric oxide (NO) and angiotensinconverting enzyme (ACE) were measured in plasma by using colorimetric methods. Vascular reactivity study was performed in rat aorta rings and the involvement of nitric oxide synthase (NOS), calcium-calmodulin complex and phosphatidylinositol-3-kinase (PI3K)/Akt pathway in the vasodilator effect was investigated. Administration of bornesitol significantly reduced the SBP, increased the plasmatic level of nitrite, and decreased ACE activity in normotensive rats. In the rat aorta, bornesitol induced endothelium-dependent vasodilatation, which was abolished by NOS blockade. While calcium-calmodulin complex inhibition decreased the vasodilator effect of bornesitol, the inhibition of PI3K/Akt pathway did not alter it. Bornesitol reduced the blood pressure by a mechanism involving an increased production or bioavailability of NO, inhibition of ACE, and by an endothelium-and NO-dependent vasodilator effect. The present results support the use of bornesitol as an active marker for the cardiovascular activity of Hancornia speciosa.

show abstract

Section: Introductionmentioning

confidence: 99%

The Cyclitol L-(+)-Bornesitol as an Active Marker for the Cardiovascular Activity of the Brazilian Medicinal Plant <i>Hancornia speciosa</i>

Moreira

Silva

Câmara

et al. 2019

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…No Brasil, a introdução dessas plantas em rituais de cura vem desde a cultura indígena, permanecendo esse conhecimento empírico até os dias de hoje. Aproximadamente 66% da população brasileira sem acesso à medicina moderna faz uso de medicamentos populares, representando muitas vezes, o único recurso terapêutico de muitas comunidades e grupos étnicos (Mazzari & Prieto, 2014).…”

Section: Introductionunclassified

Atividade bactericida do óleo essencial e extrato hidroalcoólico das folhas de Eucalyptus globulus

Everton¹,

Pereira²,

Rosa³

et al. 2020

RSD

View full text Add to dashboard Cite

The study aimed to evaluate the toxicity, total phenolics and antimicrobial activity using essential oil (OE) and hydroalcoholic extract (EH) of Eucalyptus globulus leaves against pathogenic microorganisms of clinical importance. The HE was prepared using the cold maceration method and the EO was extracted by hydrodistillation at 100°C for 3h. The toxicity assay was performed using the Artemia salina Leach bioassay. For antimicrobial activity, the Disc Diffusion technique was used against the bacteria Escherichia coli and Staphylococcus aureus. The toxicity LC50 obtained for EO was 595.2 mg L-1 and for HE it was 574.18 mg L-1 both classified as nontoxic. Regarding antimicrobial activity, EO presented inhibition halos for S. aureus and E. coli of 15 mm, while HE presented halos of 22 mm for S. aureus and E. coli of 17 mm. EO and HE showed antimicrobial activity and atoxicity, being important parameters to point out the products as a therapeutic alternative, encouraging their potential for application.

show abstract

“…Such data is necessary in order to predict and avoid interactions that may occur between the extracts and conventional drugs. These types of interactions are called herb-drug interactions (HDI) ( Mazzari and Prieto, 2014b ). In a previous literature review, we revealed that such data are known for only half of the medicinal plants traditionally used in Brazil ( Mazzari and Prieto, 2014a ).…”

Section: Introductionmentioning

confidence: 99%

In vitro Effects of Four Native Brazilian Medicinal Plants in CYP3A4 mRNA Gene Expression, Glutathione Levels, and P-Glycoprotein Activity

Mazzari¹,

Milton

Frangos³

et al. 2016

Front. Pharmacol.

View full text Add to dashboard Cite

Erythrina mulungu Benth. (Fabaceae), Cordia verbenacea A. DC. (Boraginaceae), Solanum paniculatum L. (Solanaceae) and Lippia sidoides Cham. (Verbenaceae) are medicinal plant species native to Brazil shortlisted by the Brazilian National Health System for future clinical use. However, nothing is known about their effects in metabolic and transporter proteins, which could potentially lead to herb-drug interactions (HDI). In this work, we assess non-toxic concentrations (100 μg/mL) of the plant infusions for their in vitro ability to modulate CYP3A4 mRNA gene expression and intracellular glutathione levels in HepG2 cells, as well as P-glycoprotein (P-gp) activity in vincristine-resistant Caco-2 cells (Caco-2 VCR). Their mechanisms of action were further studied by measuring the activation of human pregnane X receptor (hPXR) in transiently co-transfected HeLa cells and the inhibition of γ-glutamyl transferase (GGT) in HepG2 cells. Our results show that P-gp activity was not affected in any case and that only Solanum paniculatum was able to significantly change CYP3A4 mRNA gene expression (twofold decrease, p < 0.05), this being correlated with an antagonist effect upon hPXR (EC50 = 0.38 mg/mL). Total intracellular glutathione levels were significantly depleted by exposure to Solanum paniculatum (-44%, p < 0.001), Lippia sidoides (-12%, p < 0.05) and Cordia verbenacea (-47%, p < 0.001). The latter plant extract was able to decrease GGT activity (-48%, p < 0.01). In conclusion, this preclinical study shows that the administration of some of these herbal medicines may be able to cause disturbances to metabolic mechanisms in vitro. Although Erythrina mulungu appears safe in our tests, active pharmacovigilance is recommended for the other three species, especially in the case of Solanum paniculatum.

show abstract

Monitoramento De Interações Farmacocinéticas Entre Plantas Medicinais E Fitoterápicos E Os Medicamentos Convencionais Pelo Sistema De Farmacovigilância Brasileiro

Abstract: Monitoramento de interações farmacocinéticas entre plantas medicinais e fitoterápicos e os medicamentos convencionais pelo sistema de farmacovigilância brasileiro Pharmacovigilance in Brazil: the monitoring of herb-drug interactions using pharmacokinetic data

Cited by 7 publications

References 21 publications

The Cyclitol L-(+)-Bornesitol as an Active Marker for the Cardiovascular Activity of the Brazilian Medicinal Plant <i>Hancornia speciosa</i>

The Cyclitol L-(+)-Bornesitol as an Active Marker for the Cardiovascular Activity of the Brazilian Medicinal Plant <i>Hancornia speciosa</i>

Atividade bactericida do óleo essencial e extrato hidroalcoólico das folhas de Eucalyptus globulus

In vitro Effects of Four Native Brazilian Medicinal Plants in CYP3A4 mRNA Gene Expression, Glutathione Levels, and P-Glycoprotein Activity

Contact Info

Product

Resources

About