Moniliasis in Pediatrics

Candida Granuloma

“…At least 25 in¬ stances of candidiasis associated with either hypoparathyroidism, adrenal insufficiency, or both have been observed in children, some of whom were siblings.2 Candidiasis has also been found in 25 children (ap¬ proximately 43%) with acrodermatitis enteropathica, a syndrome characterized by chronic diarrhea, periorificial dermatitis, alopecia, and apathy.26 A primary etiologic role for C albicans or its endotoxin has been postulated but an alternative possibility is that the fungous infection is superimposed on dystropic ectodermal changes associated with the basic disease. 2,22,26 Routine diagnostic examination of the patient did not elicit any systemic or local predisposing factors and in this respect is in general agreement with studies of other patients with Candida granuloma. The ad¬ ditional special research studies also did not disclose any specific property of the fungus or defect in the defense mechanisms of the patient to explain the development of this disease.…”

Autoimmune Hypoparathyroidism

“…86,101,102 However, autopsy studies never showed invasion of the parathyroid glands or viscera by C. albicans. 27,47,71 As an alternative to direct infection by Candida, in 1966 Sjöberg, 69 and in 1970 Windorfer, 103 postulated that this fungus elaborated a toxin that impaired endocrine gland function.…”

Congenital Mycosis <i>(Candida albicans)</i>

“…1957;Bret and Coupe, 1958;Kozinn cl at.. 1958;Sharma et al. 1965], Intra-uterine infection, although suspected as early as 1957 [Larroche, 1957;Dobias, 1957], is nevertheless considered as very uncommon [Ansel, 1965: Vialatte andCharlas. 1967;Nezeloff andSarrut, 1957: Dobias, 1957;Belter, 1959].…”

“…Type and repartition of these lesions lead to the concept of an ascending infection. There are many precise arguments for such an opinion: (I) the frequent and chronicvaginal infection during the pregnancy is virulent enough to infect the new born infant during delivery [Bret and Coupe, 1958: Dobias, 1957: Siiarma cl al., 1965Kozinn el al., 1958]: clinical findings [Bret and Coupe, 1958] and experimental facts [Kozinn el al.. I960] support this concept.…”