Monilethrix Treated with Minoxidil

Rossi, Alfredo; Iorio, Alessandra; Scali, Elisabetta; Fortuna, Maria Caterina; Mari, Elena; Palese, Emma; Greco, Peter M.; Carlesimo, Marta

doi:10.1177/039463201102400129

Cited by 31 publications

(34 citation statements)

References 8 publications

(10 reference statements)

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“…Moreover, trichoscopy is a noninvasive technique that does not require expensive instruments and is very well accepted by patients. Another advantage of the method is that it is useful not only for the diagnosis, but also to evaluate the activity phase of disease and the therapeutical response to the treatment [39]. In AA, for example, it is able to recognize and distinguish yellow spots, which are a sign of disease severity, from exclamation mark hairs, which are a sign of disease activity.…”

Section: Discussionmentioning

confidence: 99%

Clinical, Histological and Trichoscopic Correlations in Scalp Disorders

et al. 2015

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Trichoscopy is the term coined for the dermoscopic imaging of scalp and hair. This diagnostic technique, simple and noninvasive, can be used as a handy bedside tool for the diagnosis and follow-up of hair and scalp disorders. It allows the recognition of morphologic structures not visible by the naked eye and provides the clinician with a range of dermoscopic findings necessary for differential diagnosis. Trichoscopy observation can be broadly grouped as interfollicular patterns and follicular patterns. Recently, a third mixed class, called the follicular plus interfollicular pattern, has been introduced. Some of these features are specific to a certain scalp disease, while others can be found in many hair disorders. Although studies suggest that the use of trichoscopy can improve clinical accuracy, further investigation is needed. This review provides update information on the trichoscopic features of the most common scalp disorders, striving to show a histopathological and clinical correlation.

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Section: Discussionmentioning

confidence: 99%

Clinical, Histological and Trichoscopic Correlations in Scalp Disorders

et al. 2015

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“…[3] Various treatment modalities like griseofulvin, retinoids, topical 2% minoxidil etc., have shown improvement in isolated cases. [4] Karincoaglu et al . described that a very good clinical and cosmetic result was obtained while treatment was continued with oral acitretin in a 7-year-old girl.…”

Section: Discussionmentioning

confidence: 99%

Monilethrix: A rare hereditary condition

2013

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Monilethrix is a rare hereditary condition generally considered to be an autosomal-dominant disorder with variable penetrance. Here, we report a case of monilethrix in a 13-year-old boy with an affected sibling. A therapeutic trial with oral N-acetyl cysteine was attempted. There was slight improvement after 2 months of therapy. The hair density, however, did not show any further improvement subsequently. Monilethrix remains as a therapeutic challenge for dermatologists.

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“…When activated by diverse stimuli, mast cells mobilize arachidonic acid through cytosolic phospholipase A2, and rapidly generate both prostaglandin 02 (47)(48)(49)(50)(51). IL-33 induces biological effects on mast cells and T cells through its receptor IL-33Rf3-chain and may have pro-inflammatory potential effects similar to the cytokines from the same family (52)(53)(54)(55)(56).…”

Section: Discussionmentioning

confidence: 99%

Impact of IL-33 on PGD2 Generation by Activated Human Cord Blood-Derived Mast Cell: Lack of Effect on Tryptase Release

et al. 2012

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Mast cells are important not only in allergic reactions, but also in inflammation and are involved in a variety of responses including the immediate release of potent inflammatory mediators after activation by cross-linking of FCERI molecules. Prostaglandin D2 (PGD2) is a major cyclooxygenase metabolite of arachidonic acid produced by mast cells and it is released following allergen challenge in allergic diseases. IL-33 is an iflammatory cytokine which is critically involved in the regulation of in vitro and in vivo cyclooxygenase production, providing a potential therapeutic target for inflammatory disorders. In this study, using human derived umbelical cord blood mast cells, we show that IL-33 (50 ng/ml), and calcium ionophore A 23187 (0.5 f.1g/ml), compound 48/80 (10-5 M) or anti-IgE (10 ug/rnl), enhaced the production ofPGD2 and this effect was inhibited by indomethacin. However, IL-33 was unable to induce tryptase release in these cells. These effects confirm the inflammatory property of IL-33 by stimulating PGD2 but not tryptase in human mast cells. The inhibitory effect of this new cytokine may have a potential therapeutic response in allergic and inflammatory diseases.Cytokines are inflammatory and immuneregulatory proteins that play a central role in the pathogenesis of allergic diseases (1-9) and inflammation (10-14). However, some cytokines are anti-inflammatory such as IL-4, IL-l 0, IL-l receptor antagonist (IL-1RA) and IL-37. Cytokines of the interleukin-l (IL-l) family, such as IL-I alpha/beta, IL-18 and lL-33, have also an important function in host defence, immune regulation, and inflammation (15)(16)(17)(18)(19)(20). The mediators released by mast cells, such as histamine, tryptase, serotonin and arachodonic acid products: PGD 2 , LTC 4 , LTD 4 , LTE 4 induce, in general, vasodilation, ronchoconstriction, cellular chemotaxis and increased vascular permeability (21-25). Most of the eicosanoids generated by mast cells are either PGD 2 or LTC 4 (26-29).

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Monilethrix Treated with Minoxidil

Cited by 31 publications

References 8 publications

Clinical, Histological and Trichoscopic Correlations in Scalp Disorders

Clinical, Histological and Trichoscopic Correlations in Scalp Disorders

Monilethrix: A rare hereditary condition

Impact of IL-33 on PGD2 Generation by Activated Human Cord Blood-Derived Mast Cell: Lack of Effect on Tryptase Release

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