MONFIT: Multi-omics factorization-based integration of time-series data sheds light on Parkinson’s disease
Katarina Mihajlović,
Noël Malod-Dognin,
Corrado Ameli
et al.
Abstract:Parkinson’s disease (PD) is a severe and complex multifactorial neurodegenerative disease with still elusive pathophysiology preventing the development of curative treatments. Molecular deep phenotyping by longitudinal multi-omics is a promising approach to identify mechanisms of PD aetiology and its progression. However, the heterogeneous data require new analysis frameworks to understand disease progression across biological entities and processes. Here, we present MONFIT, a holistic analysis pipeline that i… Show more
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