Monetite, an important calcium phosphate compound–Its synthesis, properties and applications in orthopedics

Zhou, Huan; Yang, Lei; Gbureck, Uwe; Bhaduri, Sarit B.; Sikder, Prabaha

doi:10.1016/j.actbio.2021.03.050

Cited by 57 publications

(41 citation statements)

References 128 publications

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“…Multi-component calcium phosphate (CaP) compositions containing predominantly monetite (CaHPO 4 ) with smaller additions of beta-tricalcium phosphate ( β -Ca 3 (PO 4 ) 2 , β -TCP) and calcium pyrophosphate (Ca 2 P 2 O 7 , Ca-PP) exhibit osteoinductive behaviour [ 18 ] and long-term volumetric balance between rates of bone formation and CaP degradation [ 19 ]. Although the osteoinductive properties of monetite-containing materials [ 20 ], including bone repair cements [ 21 ], and β - TCP [ 22 ] are reported, the precise role and eventual fate of Ca-PP warrants further investigation. Pyrophosphate ions (P 2 O 7 4− ) act as inhibitors of calcification and actively prevent pathological mineralisation [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Bone without borders – Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope

Shah

Jolic

Micheletti

et al. 2023

Bioactive Materials

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Section: Introductionmentioning

confidence: 99%

Bone without borders – Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope

Shah

Jolic

Micheletti

et al. 2023

Bioactive Materials

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“… 22 − 24 In addition, some other forms of doped apatite, such as fluor-carbonate hydroxyapatite, are found in fish enameloids. 25 Other biologically relevant CPCs are amorphous calcium phosphate (ACP), 26 , 27 monetite (dibasic calcium phosphate anhydrate, DCPA; CaHPO 4 ), 28 , 29 brushite (dibasic calcium phosphate dihydrate, DCPD; CaHPO 4 .2H 2 O), 30 octacalcium phosphate (OCP); Ca 8 H 2 (PO 4 ) 6 .H 2 O), 31 calcium pyrophosphate; Ca 2 P 2 O 7 ), 32 α-tricalcium phosphate (α-TCP), 33 β-tricalcium phosphate (β-TCP; Ca 3 (PO 4 ) 2 ), 34 and tetracalcium phosphate; Ca 4 (PO 4 ) 2 O). 35 Nevertheless, HA is not a resorbable form of CPC because the resorptive capacity of CPCs increases with their reduced crystallinity, such that ACP ≫ brushite > monetite > OCP > α-TCP ≫ β-TCP > HA.…”

Section: Introductionmentioning

confidence: 99%

Probing the Structure, Cytocompatibility, and Antimicrobial Efficacy of Silver-, Strontium-, and Zinc-Doped Monetite

Adawy

Dı́az

2022

ACS Appl. Bio Mater.

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Calcium phosphate phases are among the most widely accepted compounds for biomaterial applications, of which the resorbable phases have gained particular attention in recent years. Brushite and its anhydrous form monetite are among the most interesting resorbable calcium phosphate phases that can be applied as cements and for in situ fabrication of three-dimensional (3D) implants. Of these two dicalcium phosphate compounds, monetite is more stable and undergoes slower degradation than brushite. The purpose of the current study is to synthesize and dope monetite with the antimicrobial elements silver and zinc and the osteoinductive element strontium and investigate the possible structural variations as well as their biocompatibility and antimicrobial effectiveness. For this, powder X-ray diffraction (PXRD), energy-dispersive X-ray spectroscopy (EDX), scanning electron microscopy (SEM), and cryo-transmission electron microscopy (cryo-TEM) were used to thoroughly study the synthesized structures. Moreover, the ASTM E-2149-01 protocol and a cell proliferation assay were used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) and the cytocompatibility of the different phases with the Soas-2 cell line, respectively. The results confirm the successful synthesis and doping procedures, such that zinc was the most incorporated element into the monetite phase and strontium was the least incorporated element. The microbiological studies revealed that silver is a very effective antimicrobial agent at low concentrations but unsuitable at high concentrations because its cytotoxicity would prevail. On the other hand, doping the compounds with zinc led to a reasonable antimicrobial activity without compromising the biocompatibility to obviously high concentrations. The study also highlights that strontium, widely known for its osteoinductivity, bears an antimicrobial effect at high concentrations. The generated doped compounds could be beneficial for prospective studies as bone cements or for scaffold biomaterial applications.

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“…CaHPO 4 particles are soluble in bodily fluids and promote additional ion elution, nucleation, and growth of bone apatite during the biomineralization. Moreover, its biological (in vitro and in vivo) properties are discussed [68].…”

Section: Discussionmentioning

confidence: 99%

Amorphous–Crystalline Calcium Phosphate Coating Promotes In Vitro Growth of Tumor-Derived Jurkat T Cells Activated by Anti-CD2/CD3/CD28 Antibodies

et al. 2021

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A modern trend in traumatology, orthopedics, and implantology is the development of materials and coatings with an amorphous–crystalline structure that exhibits excellent biocopatibility. The structure and physico–chemical and biological properties of calcium phosphate (CaP) coatings deposited on Ti plates using the micro-arc oxidation (MAO) method under different voltages (200, 250, and 300 V) were studied. Amorphous, nanocrystalline, and microcrystalline statesof CaHPO4 and β-Ca2P2O7were observed in the coatings using TEM and XRD. The increase in MAO voltage resulted in augmentation of the surface roughness Ra from 2.5 to 6.5 µm, mass from 10 to 25 mg, thickness from 50 to 105 µm, and Ca/P ratio from 0.3 to 0.6. The electrical potential (EP) of the CaP coatings changed from −456 to −535 mV, while the zeta potential (ZP) decreased from −53 to −40 mV following an increase in the values of the MAO voltage. Numerous correlations of physical and chemical indices of CaP coatings were estimated. A decrease in the ZP magnitudes of CaP coatings deposited at 200–250 V was strongly associated with elevated hTERT expression in tumor-derived Jurkat T cells preliminarily activated with anti-CD2/CD3/CD28 antibodies and then contacted in vitro with CaP-coated samples for 14 days. In turn, in vitro survival of CD4+ subsets was enhanced, with proinflammatory cytokine secretion of activated Jurkat T cells. Thus, the applied MAO voltage allowed the regulation of the physicochemical properties of amorphous–crystalline CaP-coatings on Ti substrates to a certain extent. This method may be used as a technological mechanism to trigger the behavior of cells through contact with micro-arc CaP coatings. The possible role of negative ZP and Ca2+ as effectors of the biological effects of amorphous–crystalline CaP coatings is discussed. Micro-arc CaP coatings should be carefully tested to determine their suitability for use in patients with chronic lymphoid malignancies.

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Monetite, an important calcium phosphate compound–Its synthesis, properties and applications in orthopedics

Cited by 57 publications

References 128 publications

Bone without borders – Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope

Bone without borders – Monetite-based calcium phosphate guides bone formation beyond the skeletal envelope

Probing the Structure, Cytocompatibility, and Antimicrobial Efficacy of Silver-, Strontium-, and Zinc-Doped Monetite

Amorphous–Crystalline Calcium Phosphate Coating Promotes In Vitro Growth of Tumor-Derived Jurkat T Cells Activated by Anti-CD2/CD3/CD28 Antibodies

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