Abstract:Background
Hyperalphalipoprtoteinemia (HALP) is primarily caused by loss-of-function mutations in key genes in the reverse cholesterol transport pathway (RCT) such as cholesteryl ester transfer protein, hepatic lipase, and endothelial lipase. Angiopoietin-like protein 3 (ANGPTL3) is a natural inhibitor of hepatic lipase and endothelial lipase. We have previously shown that ANGPTL3 levels are higher in HALP subjects compared to those of control. Angiopoietin-like protein 8 (ANGPTL8) is known to promote ANGPTL3 … Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.