MOMSense: Metal-Oxide-Metal Elementary Glucose Sensor

Abunahla, Heba; Mohammad, Baker; Alazzam, Anas; Jaoudé, Maguy Abi; Al‐Qutayri, Mahmoud; Hadi, Sabina Abdul; Al-Sarawi, Said F.

doi:10.1038/s41598-019-41892-w

Cited by 41 publications

(18 citation statements)

References 71 publications

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“…Their application for non-enzymatic detection of glucose provided current against glucose concentration with a linear range from 2.2 mM to 10 mM at pH 7.0 ( Fig. 3b and c) (Abunahla et al, 2019). The MOMSense device was incorporated in microfluidic channels, fed by human sample solutions (i.e., fluids simulating body fluids) containing glucose, extracted using a suitable separation technique.…”

Section: Enzyme-free Electrochemical Glucose Sensorsmentioning

confidence: 99%

Recent advances of electrochemical and optical enzyme-free glucose sensors operating at physiological conditions

Adeel

Rahman

Caligiuri

et al. 2020

Biosensors and Bioelectronics

200

128

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Diabetes is a pathological condition that requires the continuous monitoring of glucose level in the blood. Its control has been tremendously improved by the application of point-of-care devices. Conventional enzyme-based sensors with electrochemical and optical transduction systems can successfully measure the glucose concentration in human blood, but they suffer from the low stability of the enzyme. Non-enzymatic wearable electrochemical and optical sensors, with low-cost, high stability, point-of-care testing and online monitoring of glucose levels in biological fluids, have recently been developed and can help to manage and control diabetes worldwide. Advances in nanoscience and nanotechnology have enabled the development of novel nanomaterials that can be implemented for the use in enzyme-free systems to detect glucose. This review summarizes recent developments of enzyme-free electrochemical and optical glucose sensors, as well as their respective wearable and commercially available devices, capable of detecting glucose at physiological pH conditions without the need to pretreat the biological fluids. Additionally, the evolution of electrochemical glucose sensor technology and a couple of widely used optical detection systems along with the glucose detection mechanism is also discussed. Finally, this review addresses limitations and challenges of current non-enzymatic electrochemical, optical, and wearable glucose sensor technologies and highlights opportunities for future research directions.

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Section: Enzyme-free Electrochemical Glucose Sensorsmentioning

confidence: 99%

Recent advances of electrochemical and optical enzyme-free glucose sensors operating at physiological conditions

Adeel

Rahman

Caligiuri

et al. 2020

Biosensors and Bioelectronics

200

128

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“…Most electrocatalytic processes take place via the adsorption of reactant molecules to active electrode sites. Adsorption of the reactant molecules is accompanied by breaking bonds and new intermediate formation ( Abunahla et al, 2019 ). The adsorption mechanism is affected by different factors such as non-metal catalysts deficiencies, unoccupied d-orbitals at transition metal (TM) centres, and the redox center’s optimal electronic state ( Niu et al, 2016 ).…”

Section: Electrochemical Detection Of Glucosementioning

confidence: 99%

Recent Advances in Non-Enzymatic Glucose Sensors Based on Metal and Metal Oxide Nanostructures for Diabetes Management- A Review

et al. 2021

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There is an undeniable growing number of diabetes cases worldwide that have received widespread global attention by many pharmaceutical and clinical industries to develop better functioning glucose sensing devices. This has called for an unprecedented demand to develop highly efficient, stable, selective, and sensitive non-enzymatic glucose sensors (NEGS). Interestingly, many novel materials have shown the promising potential of directly detecting glucose in the blood and fluids. This review exclusively encompasses the electrochemical detection of glucose and its mechanism based on various metal-based materials such as cobalt (Co), nickel (Ni), zinc (Zn), copper (Cu), iron (Fe), manganese (Mn), titanium (Ti), iridium (Ir), and rhodium (Rh). Multiple aspects of these metals and their oxides were explored vis-à-vis their performance in glucose detection. The direct glucose oxidation via metallic redox centres is explained by the chemisorption model and the incipient hydrous oxide/adatom mediator (IHOAM) model. The glucose electrooxidation reactions on the electrode surface were elucidated by equations. Furthermore, it was explored that an effective detection of glucose depends on the aspect ratio, surface morphology, active sites, structures, and catalytic activity of nanomaterials, which plays an indispensable role in designing efficient NEGS. The challenges and possible solutions for advancing NEGS have been summarized.

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“…Molecularly imprinted polymers (MIPs) have found wide application, particularly in sensing and biosensing, due to their high selectivity (translating into low cross-sensitivity to substances other than the intended analyte), high sensitivity to the intended analytes and fairly straightforward fabrication procedure, which does not involve as stringent purity requirements as in the case of inorganic semiconductor sensors [4]. The analytes, for which MIP-based sensors are reported, include a variety of small molecules, proteins, carbohydrates (particularly glucose) and even metal ions [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Electropolymerised Polypyrroles as Active Layers for Molecularly Imprinted Sensors: Fabrication and Applications

Glosz

Stolarczyk

2021

Materials

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Conjugated polymers are widely used in the development of sensors, but even though they are sensitive and robust, they typically show limited selectivity, being cross-sensitive to many substances. In turn, molecular imprinting is a method involving modification of the microstructure of the surface to incorporate cavities, whose shape matches that of the “template”—the analyte to be detected, resulting in high selectivity. The primary goal of this review is to report on and briefly explain the most relevant recent developments related to sensors utilising molecularly imprinted polypyrrole layers and their applications, particularly regarding the detection of bioactive substances. The key approaches to depositing such layers and the most relevant types of analytes are highlighted, and the various trends in the development of this type of sensors are explored.

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MOMSense: Metal-Oxide-Metal Elementary Glucose Sensor

Cited by 41 publications

References 71 publications

Recent advances of electrochemical and optical enzyme-free glucose sensors operating at physiological conditions

Recent advances of electrochemical and optical enzyme-free glucose sensors operating at physiological conditions

Recent Advances in Non-Enzymatic Glucose Sensors Based on Metal and Metal Oxide Nanostructures for Diabetes Management- A Review

Electropolymerised Polypyrroles as Active Layers for Molecularly Imprinted Sensors: Fabrication and Applications

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