Momordica charantia extract, a herbal remedy for type 2 diabetes, contains a specific 11β-hydroxysteroid dehydrogenase type 1 inhibitor

Blum, Andreas; Loerz, Christine; Martin, Hans-Joerg; Staab-Weijnitz, Claudia A.; Maser, Edmund

doi:10.1016/j.jsbmb.2011.09.003

Cited by 34 publications

(22 citation statements)

References 52 publications

(52 reference statements)

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“…These results might be related to a study indicating that the extracts of M. charantia inhibited the activity of α-amylase and α-glucosidase, reducing blood glucose levels (Poovitha and Parani, 2016). These results can be corroborated by other numerous studies that report antidiabetic activity of the São Caetano melon (Blum et al, 2012;Chaturvedi, 2012;Hasan and Khatoon, 2012;Xu et al, 2015;Mishra et al, 2015;Tayyab and Lal, 2016;Yousaf et al, 2016). Thus, this medicinal herb could potentially be used to treat diabetes.…”

Section: Antidiabetic Activitysupporting

confidence: 70%

Phytochemical profile and biological activities of Momordica charantia L. (Cucurbitaceae): A review

Oliveira¹,

Costa²,

Bezerra³

et al. 2018

Afr. J. Biotechnol.

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This study discusses the bioactive composition, supercritical fluid extraction and biological activities of Momordica charantia L. from the last five years. Numerous compounds that have been identified in the extracts of M. charantia, including phytosterols, terpenoids, fatty acids, phenolic compounds, phenolic acids and flavonoids were also discussed. Although, several studies reported the use of organic solvents in the extraction of these compounds, this review emphasized on supercritical fluid extraction (SFE), good selectivity, varied fractions in terms of mass yields and chemical composition obtained, in addition to providing a solvent-free extract. Moreover, the biological effects of M. charantia extracts, including their antidiabetic, neuroprotective, anti-obesogenic, antimalarial, antioxidant, antiinflammatory, antimicrobial and allelopathic activities, were discussed. These biological effects of the extracts of M. charantia can directly affect human health. The findings of this review are important, as they can guide future studies related to obtaining bioactive compounds from M. charantia and its applications.

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Section: Antidiabetic Activitysupporting

confidence: 70%

Phytochemical profile and biological activities of Momordica charantia L. (Cucurbitaceae): A review

Oliveira¹,

Costa²,

Bezerra³

et al. 2018

Afr. J. Biotechnol.

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“…The aqueous extract of the unripe fruit of M. charantia has been shown to partially stimulate insulin release from isolated Betacells of the pancreas in rats, while the fruit juice significantly increased the number of Beta-cells 6 . M. charantia has also been reported to inhibit 11Beta-hydroxysteroid dehydrogenase, a potential antidiabetes target 45 . Major active principles in M. charantia are sterols, triterpenes, glycosides notably momordin Ic, charantin, goyaglycosides, momordicosides and other cucurbitane glycosides, goyasaponins, the alkaloid momordicin, phenolic compounds, tannins, flavonoids, carotenoids and bioactive proteins like polypeptide p and alpha-momorcharin 12,44,[46][47][48][49][50] .…”

Section: Discussionmentioning

confidence: 99%

In vivo hypoglycemic effect of methanolic fruit extract of <i>Momordica charantia L</i>

Nkambo¹,

Anyama²,

Onegi³

2014

Afr H. Sci.

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Background: Momordica charantia L. is a medicinal plant commonly used in the management of diabetes mellitus. Objectives: We investigated the blood glucose lowering effect of the methanolic fruit extract of the Ugandan variety of M. charantia L. in alloxan-induced diabetic albino rats. Methods: 500g of M. charantia powder were macerated in methanol and the extract administered to two groups of alloxaninduced diabetic rats. The first group received 125mg/kg, the second 375mg/kg and a third group 7mg/ kg of metformin. A fourth group received 1ml normal saline. Fasting blood glucose (FBG) levels were measured at 0.5,1,2,3,5,8 and 12 hours and compared using one-way ANOVA. Results: There was an initial rise in FBG for 1 hour after administration of extracts followed by steep reductions. Significant reduction in FBG occurred at 2 hours for 125mg/kg of extract (-3.2%, 313±25.9 to 303±25.0mg/dL, p = 0.049), 375mg/ kg of extract (-3.9%, 356±19.7 to 342±20.3mg/dL, p = 0.001), and metformin (-2.6%, 344±21.7 to 335±21.1mg/dL, p = 0.003) when compared to normal saline. The maximum percentage reduction in FBG by both extracts occurred between 3 and 12 hours post dose. Conclusions: The methanolic fruit extract of M. charantia exhibits dose dependent hypoglycaemic activity in vivo.

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“…Recently, several proteins were isolated from M. charantia which were involved in the insulin signaling pathway. Isolated compounds such as insulin-like peptide (plant (p)-insulin), charantin, vicine, glycosides, karavilosides, fruit and seed extract, juices and powders have demonstrated potential effects in lowering blood sugar by increasing glucose uptake and glycogen synthesis in the liver, muscles, and fat cells and activating insulin receptor substrate 1 (IRS1) in skeletal muscle by tyrosine phosphorylation [46]. Some other reports stated that the hypoglycemic effects might be due to the significant increase in ␤ cell number, glucose uptake by skeletal muscle and adipose tissue, and activation of AMPK pathway that stimulates the insulin secretion [47].…”

Section: Anti-diabetic Activitymentioning

confidence: 99%

Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources – A review

Nagarani

Abirami

Siddhuraju

2014

Food Science and Human Wellness

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Plants with potential therapeutic values have been used from time immemorial to cure various ailments and infectious diseases. Of late, scientific evidences have been provided on the potential therapeutic agent exhibited by certain traditionally used vegetable extracts. The importance of wild edible plants may be traced to antiquity but systemic studies are recent. All the Momordica species have been consumed as vegetable and traditionally used for various disorders. The whole plant parts are ascribed to possess the anti-diabetic effect in traditional medicinal system. The active constituents of Momordica plant parts were cucurbitane type triterpenoids, phenolics, glycosides, and several kinds of peptides including Momordica anti-HIV protein (MAP 30). Recent reports revealed the presence of several kinds of cucurbitane type triterpenoids in leaf, stem and fruits of Momordica species having several pharmacological activities. There is lack of scientific information available on the wild species which also having several bioactive components with potential activities. So the present review compares and highlights the current knowledge of the nutritional value, phytochemistry and physiological effects of wild species with known variety.

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Momordica charantia extract, a herbal remedy for type 2 diabetes, contains a specific 11β-hydroxysteroid dehydrogenase type 1 inhibitor

Cited by 34 publications

References 52 publications

Phytochemical profile and biological activities of Momordica charantia L. (Cucurbitaceae): A review

Phytochemical profile and biological activities of Momordica charantia L. (Cucurbitaceae): A review

In vivo hypoglycemic effect of methanolic fruit extract of <i>Momordica charantia L</i>

Food prospects and nutraceutical attributes of Momordica species: A potential tropical bioresources – A review

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