Momordica anti-HIV protein MAP30 abrogates the Epstein-Barr virus nuclear antigen 1 dependent functions in host cells

Huang, Wei-Hang; Su, Wen-Min; Wang, Chung-Wei; Fang, Yue-Hao; Jian, Yuan-Wei; Hsu, Hao-Jen; Peng, Chih-Wen

doi:10.1016/j.heliyon.2023.e21486

Cited by 1 publication

(1 citation statement)

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“…This anti-HIV role was demonstrated by the α- and β-momorcharin proteins present in the BM seed. In addition, the presence of anti-retroviral protein (MAP30) was studied for the probable anti-HIV, anti-HBV, and anti-herpes activities of the BM [ 28 , 30 ]. Yet again, there is a lack of research to establish the expected role of KV-VII, -X, and -XI in HIV inhibition.…”

Section: Discussionmentioning

confidence: 99%

Anti-Infective Activity of Momordica charantia Extract with Molecular Docking of Its Triterpenoid Glycosides

Aldholmi,

Ahmad,

Shaikh

et al. 2024

Antibiotics

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Momordica charantia, commonly known as bitter melon, is a fruiting plant that has been used for several diseases including infectious diseases. In this study, we report the antibacterial, antifungal, and antiviral activity of different bitter melon fruit parts originating from India and Saudi Arabia. The in vitro experiments are supported by the molecular docking of karavilosides to verify their role in the bioactivity. The antimicrobial assays revealed activity against Candida albicans, Escherichia coli, and Staphylococcus aureus. The extracts exhibited the potent inhibition of HIV-I reverse transcriptase, with an IC50 of 0.125 mg/mL observed for the pith extract originating from Saudi Arabia and the standard drug doxorubicin. The molecular docking of karavilosides exhibited a significant affinity to reverse transcriptase comparable to Rilpivirine and higher than that of doxorubicin. These outcomes encourage the precious bioactive components of the seed and pith of the Saudi bitter melon fruits to be further studied for isolation and structure elucidation.

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Section: Discussionmentioning

confidence: 99%