The aim of this study was to examine the lifespan or number of cycles to failure of tapered rotary nickel-titanium (Ni-Ti) endodontic instruments. Simulated root canals with different curvatures were used to determine a relation between canal curvature and instrument lifespan. Using a novel mathematical model for the deformation of pseudoelastic Ni-Ti alloy, it was shown that maximum stress need not necessarily occur at the outer layer. On the basis of this observation, the Coffi n-Manson relation was modifi ed with parameters determined from this experiment. Results showed that the number of cycles to failure was infl uenced by the angle and radius of canal curvature and the size of instrument at the beginning of canal curvature. The resulting quantitative mathematical relation could be used to predict the lifespan of rotary Ni-Ti endodontic instruments under clinical conditions and thereby reduce the incidence of instrument failure in vivo.