The purpose of this study is to optimize the bonding method of the plywood suitable for cross-laminated timber (CLT) with plywood as a core by analyzing the flexural performance and failure mode according to the lamina species, the method of bonding plywood in the longitudinal direction, and whether or not adhesive is applied to the joint. In the case of the Douglas fir lamina layer, the modulus of elasticity decreased by about 11.5% due to longitudinal bonding, and the modulus of rupture increased or decreased according to the adhesive application and bonding method. The optimal conditions were derived as the butt joint without adhesive, half lap joint with adhesive, and butt joint. In the case of the larch lamina layer, the modulus of rupture and the modulus of elasticity decreased by about 15% and 40%, respectively. When using the half lab joint and tongue & groove joint, it is believed that it reduces the load transmitted to the middle layer by primarily preventing the failure on flexure at the joint of the plywood layer. From the results of this study, the larch lamina layer used in the manufacturing process of Ply-lam CLT did not show any difference based on the bonding method. Butt joint and half lap joint bonding method are determined to be suitable when using Douglas fir lamina layer.