Moment Analysis Program available on Microsoft Excel.

Tabata, Kenji; Yamaoka, Kiyoshi; Kaibara, Atsunori; Suzuki, Shingo; Terakawa, Masato; Hata, Takehisa

doi:10.2133/dmpk.14.286

Cited by 83 publications

(67 citation statements)

References 7 publications

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“…The data obtained were statistically analyzed according to Stu- were estimated with noncompartmental methods as described previously (Tabata et al, 1999).…”

Section: Methodsmentioning

confidence: 99%

A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats

Kato

Ikushiro²,

Takiguchi³

et al. 2007

Drug Metab Dispos

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ABSTRACT:We have previously suggested that the decrease in the levels of serum total thyroxine (T 4 ) and free T 4 by a single administration to rats of Kanechlor-500 (KC500) at a dose of 100 mg/kg is not necessarily dependent on the increase in hepatic T 4 -UDP-glucuronosyltransferase (UDP-GT). In the present study, we determined whether or not a consecutive treatment with KC500 at a relatively low dose (10 mg/kg i.p., once daily for 10 days) results in a decrease in the level of serum total T 4 and further investigated an exact mechanism for the KC500-induced decrease in the T 4 . At 4 days after final treatment with KC500, the serum total T 4 and free T 4 levels were markedly decreased in both Wistar and UGT1A-deficient Wistar (Gunn) rats, whereas significant increases in hepatic T 4 -UDP-GT activity were observed in

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“…The data obtained were statistically analyzed according to Stu- were estimated with noncompartmental methods as described previously (Tabata et al, 1999).…”

Section: Methodsmentioning

confidence: 99%

A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats

Kato

Ikushiro²,

Takiguchi³

et al. 2007

Drug Metab Dispos

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“…The pharmacokinetic parameters of MDZ were obtained by non-compartmental analysis using MOMENT (Excel ® ) based on the moment analytic method (20,21). AUC 0-∞ was calculated according to the trapezoidal rule.…”

Section: Methodsmentioning

confidence: 99%

Effect of Benifuuki Tea on Cytochrome P450-mediated Metabolic Activity in Rats

Hirai

Nishimura

Kurata³

et al. 2018

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“…12,13) The area under the serum concentration-time curve (AUC 0-∞ ) was calculated according to the trapezoidal rule. The maximum serum concentrations (C max ) was obtained from the actual data.…”

Section: Determination Of Serum Midazolam Concentrationsmentioning

confidence: 99%

Inhibitory Effect of Oxethazaine on Midazolam Metabolism in Rats

Namba¹,

Nishimura²,

Kurata

et al. 2017

Biological & Pharmaceutical Bulletin

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There have been few reports concerning to the drug-drug interactions (DDIs) with OTC drugs although an increase in the use of OTC drugs in recent years. This current study was conducted to clarify the DDIs through CYP3A inhibition by oxethazaine (OXZ), an antacid available as an OTC drug. Midazolam (MDZ) was used as a probe drug for CYP3A activity. In an in vivo study, a single oral dose of OXZ (50 mg/kg) was administered to rats 30, 60, or 120 min before oral MDZ administration (15 mg/kg). Serum concentrations of MDZ were analyzed by HPLC, and its pharmacokinetic parameters were compared with a water-treated control group. The inhibitory effect of OXZ on MDZ 1′-hydroxylation (MDZ 1′-OH) activity was investigated in vitro using rat liver and intestinal microsomes. Pretreatment of OXZ 120 min before MDZ administration significantly increased the area under the serum concentration-time curve (AUC 0-∞ ) of MDZ six-fold compared to the control group without a change in elimination half-life (t 1/2 ). In contrast, OXZ pretreatment 30 or 60 min before MDZ administration did not show any remarkable change in MDZ pharmacokinetic parameters. The in vitro study showed that OXZ inhibited MDZ 1′-OH activity in a concentration-dependent manner both in liver and intestinal microsomes. These results suggested that OXZ increases serum MDZ concentration presumably by the inhibition of liver and/or intestinal CYP3A activity. OXZ was predicted to cause the DDIs mediated by CYP3A inhibition, although this effect depended on the dose interval.

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Moment Analysis Program available on Microsoft Excel.

Cited by 83 publications

References 7 publications

A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats

A Novel Mechanism for Polychlorinated Biphenyl-Induced Decrease in Serum Thyroxine Level in Rats

Effect of Benifuuki Tea on Cytochrome P450-mediated Metabolic Activity in Rats

Inhibitory Effect of Oxethazaine on Midazolam Metabolism in Rats

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