Moment analysis of multibreath nitrogen washout with a variable input gas composition

Felton, C. R.; Saidel, Gerald M.; Montenegro, Hugo

doi:10.1007/bf02443860

Med. Biol. Eng. Comput.

1984

DOI: 10.1007/bf02443860

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Moment analysis of multibreath nitrogen washout with a variable input gas composition

C. R. Felton

Gerald M. Saidel

Hugo Montenegro

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1984

1992

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Cited by 2 publications

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“…In most described wash-out techniques [1 -4] a perfect stepwise change of the indicator gas fraction is not achieved due to gas remaining in the bellows and tubing of the ventilator at the beginning of a wash-out. To compensate for this, complex corrections are usually implemented [5]. Richardson et al [6] described an automated N2 washout method where a slider valve was used to achieve a step-wise change in the N 2 fraction.…”

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A simple device to inject indicator gas for wash-out tests during mechanical ventilation

et al. 1992

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Abstract.Objective: To evaluate a simple device which injects a constant fraction of indicator gas to the inspiratory mixture for performing multi-breath wash-out tests during controlled ventilation. Design: the technique in which the indicator gas is injected at the mouth of the patient (post-mix) is compared with the technique where the indicator gas is administered in the bellows of the ventilator (pre-mix). Setting." Surgical Intensive Care Unit of a University Hospital. Patients." 10 post-operative mechanically ventilated patients. Interventions: None. Measurements and results: 3 wash-out tests with the post-mix and 3 wash-out tests with the pre-mix method were performed within an hour on every patient. The calculated mean end expiratory lung volume (EEV) was 1.91 _+0.871 with the post-mix technique and 1.89_+0.881 with the premix technique. There was a good agreement with a mean difference of -1.9_+6.5% in the calculated EEV values by the two different techniques. Conclusion: The described injector is an affordable device, is easy to assemble and can be incorporated in most electronically regulated ventilators to perform multi-breath indicator gas wash-out tests for pulmonary monitoring at the bed side of ICU patients.

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A simple device to inject indicator gas for wash-out tests during mechanical ventilation

et al. 1992

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Inspiratory flow effects on mechanically ventilated patients: lung volume, inhomogeneity, and arterial oxygenation

1984

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Changes in the inspiratory flow rate of mechanically ventilated patients can affect arterial oxygenation. Although the mechanism producing this alteration is not certain, one possible mechanism is a change in ventilation inhomogeneity. This study was performed to determine if the inspiratory flow setting would affect ventilation inhomogeneity in patients who have minimal or no lung disease, but who require mechanical ventilation after cardiopulmonary bypass surgery. When inspiratory flows were doubled, PaO2 increased and FRC fell. However, no associated change in ventilation inhomogeneity was detected. It is concluded that inspiratory flow rate can affect arterial oxygenation of subjects without severe obstructive pulmonary disease through mechanisms other than altering ventilation inhomogeneity, such as changes in cardiac output or in distribution of perfusion.

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Moment analysis of multibreath nitrogen washout with a variable input gas composition

Cited by 2 publications

References 6 publications

A simple device to inject indicator gas for wash-out tests during mechanical ventilation

A simple device to inject indicator gas for wash-out tests during mechanical ventilation

Inspiratory flow effects on mechanically ventilated patients: lung volume, inhomogeneity, and arterial oxygenation

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