Molybdenum(ii) complexes with p-substituted BIAN ligands: synthesis, characterization, biological activity and computational study

Abstract

These complexes crystallize as the less common axial isomer and reach EC50 < 1.8 μM against HeLa cell lines.

Effect of the 2-R-Allyl and Chloride Ligands on the Cathodic Paths of [Mo(η3-2-R-allyl)(α-diimine)(CO)2Cl] (R = H, CH3; α-diimine = 6,6′-Dimethyl-2,2′-bipyridine, Bis(p-tolylimino)acenaphthene)

“…While most of the bipy complexes known exhibit this arrangement, it is worth noting that this structure is observed here for the first time in a complex of an N -aryl-Bian ligand. Indeed, all the analogous complexes with the large and strong π-acceptor, N -aryl-Bian, always adopt the less symmetrical type B (axial) structure. ,− As has been widely observed previously, in all three complexes, the open face of the allyl ligand lies over the CO ligands (i.e., the endo isomer is preferred).…”

Electrochemical and Mechanistic Study of Oxidative Degradation of Favipiravir by Electrogenerated Superoxide through Proton-Coupled Electron Transfer

“…T-1105 is a prodrug, which needs to be metabolized to its active form, pyrazine-RTP . Then, pyrazine-RTP prevents virus multiplication by their analogue effect but cannot kill the virus. , Therefore, the immune response must be used to kill the virus while also preventing it from multiplying . Considering these biological conditions for its mechanism of action in vivo , the effective concentration of its active form after the metabolization will be lower, although T-705 is available in both oral and intravenous formulations. ,, Regarding the favipiravir as a prodrug of the RNA polymerase inhibitor, the purpose is to supply favipiravir-RTP; the active form is a purine nucleic acid analogue vicinity of the virus in inflamed organs such as the lung.…”

Redox‐active BIAN‐based Diimine Ligands in Metal‐Catalyzed Small Molecule Syntheses**

“…BIAN ligands display an especially rich coordination and redox chemistry in metal complexes of many main group and transition elements. [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ] Despite numerous literature reports on metal/BIAN‐catalyzed reactions, this review will be limited to successful implementations that have documented a distinct behavior of BIAN ligands. Therefore, investigations in which various ligand families have been employed and the use of BIANs showed no beneficial effect over other (diimine) ligands are not specifically addressed.…”

“…[13] BIAN ligands have been reported to effectively coordinate to almost all main group elements [17][18][19][20][21] and transition metals. [22][23][24][25][26][27] The resultant stereoelectronic properties including coordination modes, redox states, magnetic properties as well as the applications to chemical transformations have been varied to a great extent. Although N-aryl substituted BIAN ( Ar BIAN) compounds were first described in the 1960s, [28,29] it was not until the 1990s that they were first employed in catalytic applications by the group of Elsevier.…”