Molybdenum (IV) Sulfide Nanosheet-Based Aptasensor for the Label-Free Determination of Bisphenol A (BPA) by Electrochemical Impedance Spectroscopy (EIS)

Bao, Yiwang; Ye, Sudan; Zhou, Chenyuan; Ling, Chen

doi:10.1080/00032719.2022.2039933

Cited by 5 publications

(4 citation statements)

References 23 publications

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“…The variation tendencies of electrical signals are similar to those of some previous reports. 44,45 The result also confirms the successful fabrication of electrochemical aptasensors based on these functional materials. In particular, the prepared sensors show greatly enhanced EIS Nyquist plots after immersing in the aptamer solution (0.1 μg mL −1 ) to obtain the electrochemical aptasensor.…”

Section: Resultssupporting

confidence: 58%

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An electrochemical impedimetric platform formed by a CNT@UiO-66 nanocomposite for quantitative analysis of oxytetracycline

et al. 2023

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Section: Resultssupporting

confidence: 58%

Section: Electrochemical Detectionsupporting

confidence: 65%

An electrochemical impedimetric platform formed by a CNT@UiO-66 nanocomposite for quantitative analysis of oxytetracycline

et al. 2023

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“…The limit of detection (LOD) for BPA was determined to be 0.1 μM based on the fact that the signal change was three times that of the standard deviation of the blank sample signal. Compared with other methods ( Table S3 ) [ 11 , 14 , 22 , 24 , 25 , 36 , 37 , 38 , 39 , 40 , 41 ], our method shows a medium sensitivity, because this aptamer has binding affinities with K d at the μM level and this aptasensor does not involve a signal amplification strategy. However, our electrochemical aptasensor shows advantages such as simple operation and rapid analysis.…”

Section: Resultsmentioning

confidence: 95%

The Characterization of Binding between Aptamer and Bisphenol A and Developing Electrochemical Aptasensors for Bisphenol A with Rationally Engineered Aptamers

Liu

Yu²,

Zhao³

2022

Biosensors

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Bisphenol A (BPA) is widely used in the manufacture of polycarbonate and epoxy-resin-based products, and BPA contamination often happens in a variety of types of environment and food stuffs. BPA can cause many harmful effects to health due to its high toxicity. The rapid detection of BPA is of great significance in environmental monitoring and food safety. Nucleic acid aptamers show advantages in biosensors due to good chemical stability, the ease of labeling functional groups, and target binding that induces conformation change. Here, we performed a thorough characterization of the binding performance of one 60-nt anti-BPA DNA aptamer with isothermal titration calorimetry (ITC). We found the crucial region of the aptamer sequence for affinity binding with BPA, and the aptamer was able to be truncated to 29-nt DNA without losing affinity. We then developed a simple reagent-less electrochemical aptamer-based sensor for rapid BPA detection with this engineered aptamer. The truncated aptamer with a redox tag methylene blue (MB) was immobilized on a gold electrode. BPA-binding induced the conformation change of the MB-labeled aptamer, moving the MB close to the electrode surface and causing a significant current increase in MB in square wave voltammetry (SWV). Under optimized conditions, we achieved the quantitative detection of BPA with a detection limit of BPA at 0.1 μM. This sensor showed quick response to BPA and could be regenerated by washing with deionized water. This sensor was selective, and it allowed detecting BPA in complex samples, showing its potential in practice. This study will help in further applications of the aptamers of BPA.

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“…Most recently, molybdenum disulfide (MoS 2 ) nanosheets were utilized to make electrochemical biosensors with good sensitivity [69]. Owing to their unique properties and graphene-like structures with an outstanding electron mobility and large surface-to-volume ratios, they have attracted an increasing number of scientists' interests.…”

Section: Molybdenum Disulfide Nanosheet-based Sensorsmentioning

confidence: 99%

Aptamer-Based Optical and Electrochemical Sensors: A Review

Farid,

Ghosh,

Dutta

et al. 2023

Chemosensors

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There is a pressing need to identify recent directions in the field of aptamer-based sensing. DNA aptamers that are synthetically generated by in vitro selection mechanisms using the SELEX technique are single-stranded oligonucleotides which are selected to bind to a target with favorable sensitivity and selectivity. These aptamers have attracted significant attention due to their high binding affinity and ability to be easily engineered and provide various detection modes in what are known as aptasensors. Our aim is to focus on specialized detection strategies that have gained less attention but are of vital importance, such as optical detection in live cells, fluorescence polarization sensing, multi-analyte detection, colorimetric bioassays, wavelength shifting, and electrochemical-based detection. This will provide us with a perspective to facilitate developments in aptasensor technology for various targets, promising a bright future for biological receptors in the field of biosensing.

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Molybdenum (IV) Sulfide Nanosheet-Based Aptasensor for the Label-Free Determination of Bisphenol A (BPA) by Electrochemical Impedance Spectroscopy (EIS)

Cited by 5 publications

References 23 publications

An electrochemical impedimetric platform formed by a CNT@UiO-66 nanocomposite for quantitative analysis of oxytetracycline

An electrochemical impedimetric platform formed by a CNT@UiO-66 nanocomposite for quantitative analysis of oxytetracycline

The Characterization of Binding between Aptamer and Bisphenol A and Developing Electrochemical Aptasensors for Bisphenol A with Rationally Engineered Aptamers

Aptamer-Based Optical and Electrochemical Sensors: A Review

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