Molybdenum disulfide—gold nanoparticle nanocomposite in field-effect transistor back-gate for enhanced C-reactive protein detection

Dalila, N R; Arshad, M.K. Md; Gopinath, Subash C. B.; Nuzaihan, M. N. M.; Fathil, M. F. M.

doi:10.1007/s00604-020-04562-7

Cited by 20 publications

(11 citation statements)

References 50 publications

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“…Dalila et al [ 65 ] used a molybdenum disulfide–gold nanoparticle nanocomposite in a back-gated FET for the femtomolar detection of CRP. The presence of the nanocomposite provided large plane properties, which resulted in the stable composition of matter in liquid and gaseous states.…”

Section: Infection-mediated Clinical Biomarkers and Their Electrical Biosensorsmentioning

confidence: 99%

“… ( A ) Electrochemical biosensors: ( a ) origami paper-based sensing of CRP (reprinted with permission from [ 59 ]), ( b ) interdigitated wave-shaped microelectrode-based impedimetric sensor (reprinted from [ 60 ]), ( c ) electrochemical sensing of CRP with ferrocene thiol-coated gold electrode (reprinted from [ 61 ]), and ( d ) sandwich-type sensor with nanohybrid materials for CRP detection (reproduced from [ 62 ]). ( B ) Electronic biosensors: ( a ) PAMAM-modified CNT-based FET (reprinted with permission from [ 63 ]), ( b ) nanowire-based FET (reprinted from [ 64 ]), and ( c ) nanocomposite-based FET for CRP detection (reprinted with permission from [ 65 ]). …”

Section: Figurementioning

confidence: 99%

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Infection-Mediated Clinical Biomarkers for a COVID-19 Electrical Biosensing Platform

Selvarajan

Gopinath

Zin

et al. 2021

Sensors

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The race towards the development of user-friendly, portable, fast-detection, and low-cost devices for healthcare systems has become the focus of effective screening efforts since the pandemic attack in December 2019, which is known as the coronavirus disease 2019 (COVID-19) pandemic. Currently existing techniques such as RT-PCR, antigen–antibody-based detection, and CT scans are prompt solutions for diagnosing infected patients. However, the limitations of currently available indicators have enticed researchers to search for adjunct or additional solutions for COVID-19 diagnosis. Meanwhile, identifying biomarkers or indicators is necessary for understanding the severity of the disease and aids in developing efficient drugs and vaccines. Therefore, clinical studies on infected patients revealed that infection-mediated clinical biomarkers, especially pro-inflammatory cytokines and acute phase proteins, are highly associated with COVID-19. These biomarkers are undermined or overlooked in the context of diagnosis and prognosis evaluation of infected patients. Hence, this review discusses the potential implementation of these biomarkers for COVID-19 electrical biosensing platforms. The secretion range for each biomarker is reviewed based on clinical studies. Currently available electrical biosensors comprising electrochemical and electronic biosensors associated with these biomarkers are discussed, and insights into the use of infection-mediated clinical biomarkers as prognostic and adjunct diagnostic indicators in developing an electrical-based COVID-19 biosensor are provided.

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Section: Infection-mediated Clinical Biomarkers and Their Electrical Biosensorsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Infection-Mediated Clinical Biomarkers for a COVID-19 Electrical Biosensing Platform

Selvarajan

Gopinath

Zin

et al. 2021

Sensors

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“…For that, 1 M of diluted ethanolamine was placed on the gold-nanourchin-antibody modified IDE and waited for 30 min to mask the uncovered APTES surface. 25 Further, the electrode was washed by PBS, and then, the level of current was noted at this point. Initially, 1 nM of NfL was interacted on the gold-urchin-antibody surface and kept for 10 min.…”

Section: Detection Of Nfl Antigen On Gold-nanourchin-antibody Modifiementioning

confidence: 99%

Gold-nanourchin complexed silicon dioxide-probe on gap-fingered interdigitated electrode surface for Parkinson’s Disease determination by current–volt measurement

Shi²,

Zhang

et al. 2021

Nanomaterials and Nanotechnology

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Parkinson’s disease (PD) is a nervous disorder, affects physical movement, and leads to difficulty in balancing, walking, and coordination. A novel sensor is mandatory to determine PD and monitor the progress of the treatment. Neurofilament light chain (NfL) has been recognized as a good biomarker for PD and also helps to distinguish between PD and atypical PD syndromes. Immunosensor was generated by current–volt measurement on gap-fingered interdigitated electrode with silicon dioxide surface to determine NfL level. To enhance the detection, anti-NfL antibody was complexed with gold-nanourchin and immobilized on the sensing electrode. The current–volt response was gradually increased at the linear detection range from 100 fM to 1 nM. Limit of detection and sensitivity were 100 fM with the signal-to-noise ratio at n = 3 on a linear curve ( y = 0.081 x + 1.593; R 2 = 0.9983). Limit of quantification falls at 1 pM and high performance of the sensor was demonstrated by discriminating against other neurogenerative disease markers, in addition, it was reproducible even in serum-spiked samples. This method of detection system aids to measure the level of NfL and leads to determine the condition with PD.

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“…16 The stability of the sensor can be obtained by implementing a good surface chemistry between biomolecules and also the sensor surface. 17 Hence, due to an elevating number of stress cardiomyopathy cases associating with global pandemic, presently biosensor is capable to decline the amount new cases evolving every day. The integration of nanomaterial could help by increasing the sensing performance.…”

Section: Highlightsmentioning

confidence: 99%

“…The conjugation between targets and nanomaterial can be covalent binding or noncovalent binding 16 . The stability of the sensor can be obtained by implementing a good surface chemistry between biomolecules and also the sensor surface 17 . Hence, due to an elevating number of stress cardiomyopathy cases associating with global pandemic, presently biosensor is capable to decline the amount new cases evolving every day.…”

Section: Introductionmentioning

confidence: 99%

Current strategies with sensing technologies to eliminate stress cardiomyopathy

Sun

et al. 2021

Biotech and App Biochem

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Stress cardiomyopathy refers weakening of heart muscle due to the continuous stress. Generally, the severe status of stress cardiomyopathy has been revealed after damaging the muscles and measured by the physical changes in the heart system. To overcome this issue, biosensor can be used, which could eliminate the late identification stress cardiomyopathy. With biosensors, different stress markers such as epinephrine, dopamine, catecholamine, α‐amylase, norepinephrine, serotonin and cortisol have been identified by a wide range of developments. These biosensors are available from laboratory to industry at the ranges of nano to macrodevices. To merge with the identification of stress cardiomyopathy, the above strategies might be utilized properly and can aid to reduce the stress‐related problems. This overview gleaned the currently available biosensing methods and the associated biomarkers at various stages of the developments and implementations of stress cardiomyopathy.

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Molybdenum disulfide—gold nanoparticle nanocomposite in field-effect transistor back-gate for enhanced C-reactive protein detection

Cited by 20 publications

References 50 publications

Infection-Mediated Clinical Biomarkers for a COVID-19 Electrical Biosensing Platform

Infection-Mediated Clinical Biomarkers for a COVID-19 Electrical Biosensing Platform

Gold-nanourchin complexed silicon dioxide-probe on gap-fingered interdigitated electrode surface for Parkinson’s Disease determination by current–volt measurement

Current strategies with sensing technologies to eliminate stress cardiomyopathy

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