Molybdenum-based hetero-nanocomposites for cancer therapy, diagnosis and biosensing application: Current advancement and future breakthroughs

Dhas, Namdev; Kudarha, Ritu; Garkal, Atul; Ghate, Vivek; Sharma, Shilpa; Panzade, Prabhakar; Khot, Shubham; Chaudhari, Pinal; Singh, Ashutosh; Paryani, Mitali; Lewis, Shaila; Garg, Neha; Singh, Narinder; Bangar, Priyanka; Mehta, Tejal

doi:10.1016/j.jconrel.2020.12.015

Cited by 46 publications

(15 citation statements)

References 261 publications

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“…However, the side effects of photosensitization and damages to skin tissues raise other concerns. 3 In recent years, the development of nanoparticles (NPs), especially multifunctional smart NPs, has exhibited many unprecedented properties for the application of NP-mediated drug delivery due to their capacities to noninvasively overcome the BBB for the treatment of CNS diseases. 4 The biggest advantage to apply smart NPs is that they can be engineered to react in a predictable and specific way to the external and internal stimuli, which improves the control of the drug delivery process.…”

Section: Introductionmentioning

confidence: 99%

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Zhang

Sigdel

Mintz

et al. 2021

IJN

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Drug delivery across the blood–brain barrier (BBB) is one of the biggest challenges in modern medicine due to the BBB’s highly semipermeable property that limits most therapeutic agents of brain diseases to enter the central nervous system (CNS). In recent years, nanoparticles, especially carbon dots (CDs), exhibit many unprecedented applications for drug delivery. Several types of CDs and CD-ligand conjugates have been reported successfully penetrating the BBB, which shows a promising progress in the application of CD-based drug delivery system (DDS) for the treatment of CNS diseases. In this review, our discussion of CDs includes their classification, preparations, structures, properties, and applications for the treatment of neurodegenerative diseases, especially Alzheimer’s disease (AD) and brain tumor. Moreover, abundant functional groups on the surface, especially amine and carboxyl groups, allow CDs to conjugate with diverse drugs as versatile drug nanocarriers. In addition, structure of the BBB is briefly described, and mechanisms for transporting various molecules across the BBB and other biological barriers are elucidated. Most importantly, recent developments in drug delivery with CDs as BBB-penetrating nanodrugs and drug nanocarriers to target CNS diseases especially Alzheimer’s disease and brain tumor are summarized. Eventually, future prospects of the CD-based DDS are discussed in combination with the development of artificial intelligence and nanorobots.

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Section: Introductionmentioning

confidence: 99%

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Zhang

Sigdel

Mintz

et al. 2021

IJN

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“…Photothermal therapy (PTT), utilizing photothermal agents [e.g., noble metal nanoparticles ( Liu et al, 2020 ; Zheng et al, 2020 ), transition metal sulfides ( Ai et al, 2021 ; Dhas et al, 2021 ), black phosphorus ( Jana et al, 2020 ), phthalocyanines (PCs) ( Taratula et al, 2015 ; Jin et al, 2019 ; Li et al, 2019 )], could efficiently absorb light and convert photon energy into heat and cause the thermal ablation of adjacent tumor cells ( Camidge et al, 2019 ). However, some drawbacks, particularly poor thermal stability and low biocompatibility, had severely limited its wide application in biomedicine.…”

Section: Introductionmentioning

confidence: 99%

Docetaxel-Loaded Novel Nano-Platform for Synergistic Therapy of Non-Small Cell Lung Cancer

Feng

Xiong

2022

Front. Pharmacol.

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Nowadays, non-small cell lung cancer (NSCLC) is threatening the health of all mankind. Although many progresses on treatment of lung cancer have been achieved in the past few decades, the current treatment methods are still traditional surgery, radiotherapy, and chemotherapy, which had poor selectivity and side effects. Lower-toxicity and more efficient treatments are in sore need. In this paper, a smart nanodelivery platform based on photothermal therapy, chemotherapy, and immunotherapy was constructed. The nanoparticles are composed of novel photothermal agents, Mn-modified phthalocyanine derivative (MnIIIPC), docetaxel (DTX), and an effective targeting molecule, hyaluronic acid. The nanoplatform could release Mn2+ from MnIIIPC@DTX@PLGA@Mn2+@HA(MDPMH) and probably activate tumor immunity through cGAS-STING and chemotherapy, respectively. Furthermore, DTX could be released in the process for removal of tumor cells. The “one-for-all” nanomaterial may shed some light on treating NSCLC in multiple methods.

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“…Molybdenum-based materials can be divided into two categories: transition metal oxides composed of molybdenum dioxide and molybdenum trioxide, and TMDCs composed of molybdenum disulfide. Transition metal molybdenum oxide has a similar, adjustable, local SPR effect to precious metal nanomaterials ( 110 ). Molybdenum trioxide nanoparticles have been reported to have excellent light absorption ability in the NIR region and can produce singlet oxygen under the irradiation of NIR light.…”

Section: Classification Of Photothermal Nanomaterialsmentioning

confidence: 99%

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

et al. 2022

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The aggressive growth of cancer cells brings extreme challenges to cancer therapy while triggering the exploration of the application of multimodal therapy methods. Multimodal tumor therapy based on photothermal nanomaterials is a new technology to realize tumor cell thermal ablation through near-infrared light irradiation with a specific wavelength, which has the advantages of high efficiency, less adverse reactions, and effective inhibition of tumor metastasis compared with traditional treatment methods such as surgical resection, chemotherapy, and radiotherapy. Photothermal nanomaterials have gained increasing interest due to their potential applications, remarkable properties, and advantages for tumor therapy. In this review, recent advances and the common applications of photothermal nanomaterials in multimodal tumor therapy are summarized, with a focus on the different types of photothermal nanomaterials and their application in multimodal tumor therapy. Moreover, the challenges and future applications have also been speculated.

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Molybdenum-based hetero-nanocomposites for cancer therapy, diagnosis and biosensing application: Current advancement and future breakthroughs

Cited by 46 publications

References 261 publications

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Carbon Dots: A Future Blood–Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Docetaxel-Loaded Novel Nano-Platform for Synergistic Therapy of Non-Small Cell Lung Cancer

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

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