Molybdenum and sulphate in the diet and the effect on the molybdenum content of the milk of grazing sheep

Hogan, K. G.; Hutchinson, Anthony J.

doi:10.1080/00288233.1965.10419902

Cited by 9 publications

(5 citation statements)

References 5 publications

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“…SGOT activities were determined using the 2, 4-dinitrophenyl hydrazine method published by Dade Reagents (Inc.) (1965). Other analytical methods were as indicated elsewhere (Hogan and Hutchinson 1965) .…”

Section: Methodsmentioning

confidence: 99%

The effect of a molybdate and sulphate supplement on the accumulation of copper in the livers of penned sheep

Hogan¹,

Money²,

Blayney³

1968

New Zealand Journal of Agricultural Research

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ABSTRACf Four groups of 10 ewes each were housed in pens and fed, ad lib., a basal diet of lucerne chaff. A summary of additional treatments. given in the form of feed concentrates, is as follows:-Group 1 : 4 oz of sheep nuts containing added sodium molybdate Group 2 Group 3 Group 4 and calcium sulphate. 4 oz of sheep nuts containing added calcium carbonate. : 4 oz of sheep nuts only. : 16 oz of sheep nuts only. Analyses of feed components showed that copper concentrations were within normal limits. Nevertheless, two sheep in group 4 died from copper poisoning, about 15 months after the start of the experiment. After 14 months mean serum glutamic oxalacetic transaminase (SGOT) activities for groups 2, 3, and 4 were each greater than those for group 1, the differences in the cases of groups 2 and 4 being statistically significant. By means of li:ver samples taken by biopsy it was found that, over a 14-month period, mean liver copper concentrations (on a dry weight basis) had increased by 228 p.p.m., 798 p.p.m., 769 p.p.m., and 1,210 p.p.m. for groups 1, 2, 3, and 4 respectively, the differences between means for groups 2, 3, or 4 being statistically significant as compared with that for group 1. The differences between the means for group 2 or 3 as compared with that for group 1 were also significant. It was concluded that some dietary factor, probably associated with the concentrate, facilitated excessive storage of copper in liver, and that rate of accumulatioa was greatly reduced when a supplement of molybdate and sulphate was given.

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Section: Methodsmentioning

confidence: 99%

The effect of a molybdate and sulphate supplement on the accumulation of copper in the livers of penned sheep

Hogan¹,

Money²,

Blayney³

1968

New Zealand Journal of Agricultural Research

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“…Other studies provide evidence that molybdenum in milk rapidly raises when dietary molybdenum is high. In sheep milk, Hogan and Hutchinson (1965) found values of < 10 lg/L (unsupplemented-Mo feed) to 980 lg/L with 12.5 mg Mo/kg complete fed. Palmer et al (1989) reported a range of molybdenum concentration in normal cow's milk between 18 and 120 lg/kg; the highest level of molybdenum (2,100 lg/kg) was found for a cow fed 200 mg Mo/kg feed.…”

Section: Deposition Studiesmentioning

confidence: 95%

“…In ruminants, the molybdenum content of milk is low (Friesecke, 1994); appreciable molybdenum excretion in milk can only be observed following a high molybdenum intake (Hogan and Hutchinson, 1965;Palmer et al, 1989).…”

Section: Absorption Distribution Metabolism and Excretion (Adme)mentioning

confidence: 99%

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Safety and efficacy of a molybdenum compound (E7) sodium molybdate dihydrate as feed additive for sheep based on a dossier submitted by Trouw Nutrition International B.V.

Additives¹,

Bampidis²,

Azimonti³

et al. 2019

EFS2

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Safety and efficacy of a molybdenum compound (E7) sodium molybdate dihydrate as feed additive for sheep based on a dossier submitted by Trouw Nutrition International B.V. AbstractFollowing a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on safety and efficacy of sodium molybdate dihydrate for sheep, based on a dossier submitted for the re-evaluation of the additive. The additive is currently authorised in the EU for all animal species as 'Nutritional additive' -'Compounds of trace elements'. Taking the optimal Cu:Mo ratio of 3-10, and the highest total copper level authorised in complete feeds for sheep (15 mg/kg), the FEEDAP Panel concluded that 2.5 mg total Mo/kg complete feed is safe for sheep. Considering (i) a safe intake of 0.6 mg Mo/day, (ii) the estimate average intake figure from food in Europe (generally less than 100 lg/day), (iii) the contribution of foods of animal origin to the total molybdenum intake (estimated to be up to 22 %), and (iv) that molybdenum would not accumulate in edible tissues/products of sheep fed molybdenum supplemented diets up to the upper safe level, the FEEDAP Panel concluded that the use of sodium molybdate as a additive in sheep at 2.5 mg total Mo/kg complete feed is safe for consumers. The additive under assessment feed poses no risk by inhalation to users; it is a skin and eye irritant, but it is not considered as a skin sensitiser. Sodium molybdate used up to 2.5 mg Mo/kg complete sheep feed poses no concerns for the safety for the environment. The FEEDAP Panel recognises that molybdenum does not need to be added to diets to cover the nutritional needs of molybdenum of sheep. Molybdenum supplementation in sheep feed is considered effective in order to guarantee an adequate balance with copper, when the Cu:Mo ratio in the diet is in the range 3-10.

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“…In most cases, symptoms of the resulting tungsten toxicity can be partially or totally counteracted by supplementing the diet with molybdate, suggesting that tungstate competes with molybdate for sites of activity in the animal. ARCHIBALD (1951) and HAGAN and HUTCHINSON (1965) have independently found that increasing Mo in the diet of dairy cattle leads to higher Mo levels in the milk, while sulfate additions to the diet markedly reduced the levels of Mo in milk. When Mo levels in the diet of dairy WARD and SCOTf (1973) also measured increased Mo concentrations in milk from cows ingesting high levels of Mo in feed and water.…”

Section: B) Molybdenum In Animal Nutritionmentioning

confidence: 99%

Molybdenum in the environment

1980

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Molybdenum and sulphate in the diet and the effect on the molybdenum content of the milk of grazing sheep

Cited by 9 publications

References 5 publications

The effect of a molybdate and sulphate supplement on the accumulation of copper in the livers of penned sheep

The effect of a molybdate and sulphate supplement on the accumulation of copper in the livers of penned sheep

Safety and efficacy of a molybdenum compound (E7) sodium molybdate dihydrate as feed additive for sheep based on a dossier submitted by Trouw Nutrition International B.V.

Molybdenum in the environment

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