Molt‐independent growth inhibition of <i>Daphnia magna</i> by a vertebrate antiandrogen

LeBlanc, Gerald A.; McLachlan, James B.

doi:10.1002/etc.5620180715

Cited by 28 publications

(3 citation statements)

References 33 publications

(46 reference statements)

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“…The anti-androgen cyproterone acetate severely reduced growth of D. magna without eliciting any discernible effect on moult frequency (145). Effects of several anti-androgens (cyproterone acetate, linuron, vinclozolin, p,p'-DDE) on the reproductive system of copepods revealed varied effects, although consistent among the treatments were degeneration of spermatocytes and deformed spermatophores (163).…”

Section: Responses To Endocrine Disruptorsmentioning

confidence: 96%

“…Whether or not crustaceans utilize estrogen, androgen, and progestogen signaling pathways has been debated for decades (145). Evidence in support of these signaling pathways is based largely upon observational studies; while, evidence against the existence of these signaling pathways is supported by genomic investigations and evolutionary biology.…”

Section: Vertebrate-type Sex Steroidsmentioning

confidence: 99%

“…The NOEC or LOEC was used as a surrogate for the CV where both values were not available 2. Value was determined using EC50 with Neomysis and maximum acceptable toxicant concentration (MATC) with Gammarus 3 (192),4 (193),5 (20),6 (145).…”

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confidence: 99%

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A Crab Is Not a Fish: Unique Aspects of the Crustacean Endocrine System and Considerations for Endocrine Toxicology

2021

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Crustaceans—and arthropods in general—exhibit many unique aspects to their physiology. These include the requirement to moult (ecdysis) in order to grow and reproduce, the ability to change color, and multiple strategies for sexual differentiation. Accordingly, the endocrine regulation of these processes involves hormones, receptors, and enzymes that differ from those utilized by vertebrates and other non-arthropod invertebrates. As a result, environmental chemicals known to disrupt endocrine processes in vertebrates are often not endocrine disruptors in crustaceans; while, chemicals that disrupt endocrine processes in crustaceans are often not endocrine disruptors in vertebrates. In this review, we present an overview of the evolution of the endocrine system of crustaceans, highlight endocrine endpoints known to be a target of disruption by chemicals, and identify other components of endocrine signaling that may prove to be targets of disruption. This review highlights that crustaceans need to be evaluated for endocrine disruption with consideration of their unique endocrine system and not with consideration of the endocrine system of vertebrates.

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Section: Responses To Endocrine Disruptorsmentioning

confidence: 96%

Section: Vertebrate-type Sex Steroidsmentioning

confidence: 99%

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A Crab Is Not a Fish: Unique Aspects of the Crustacean Endocrine System and Considerations for Endocrine Toxicology

2021

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Metabolomic responses to sublethal contaminant exposure in neonate and adult Daphnia magna

Wagner

Simpson

2016

Enviro Toxic and Chemistry

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The use of consumer products and pharmaceuticals that act as contaminants entering waterways through runoff and wastewater effluents alters aquatic ecosystem health. Traditional toxicological endpoints may underestimate the toxicity of contaminants, as lethal concentrations are often orders of magnitude higher than those found within freshwater ecosystems. While newer techniques examine the metabolic responses of sublethal contaminant exposure, there has been no direct comparison with ontogeny in Daphnia. It was hypothesized that Daphnia magna would have distinct metabolic changes after 3 different sublethal contaminant exposures, because of differences in the toxic mode of action and ontogeny. To test this hypothesis, the proton nuclear magnetic resonance metabolomic profiles were measured in D. magna aged day 0 and 18 after exposure to 28% of the lethal concentration of 50% of organisms tested (LC50) of atrazine, propranolol, and perfluorooctanesulfonic acid (PFOS) for 48 h. Principal component analysis revealed significant separation of contaminants from the control daphnids in both neonates and adults exposed to propranolol and PFOS. In contrast, atrazine exposure caused separation from the controls in only the adult D. magna. Minimal ontogenetic changes in the targeted metabolites were seen after exposure to propranolol. For both atrazine and PFOS exposures ontogeny exhibited unique changes in the targeted metabolites. These results indicate that, depending on the contaminant studied, neonates and adults respond uniquely to sublethal contaminant exposure. Environ Toxicol Chem 2017;36:938-946. © 2016 SETAC.

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Use of freshwater rotifer Brachionus calyciflorus in screening assay for potential endocrine disruptors

Preston

Snell

Robertson

et al. 2000

Enviro Toxic and Chemistry

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eports of the effectsofendocrinedisruptorsonaquatic invertebrates arebecoming increasingly common. However, little is known about the endocrine systems of most aquatic invertebrates, limiting the development of assays based on endocrine mechanisms. As a result, endocrine disruption is often inferred through the effects caused by the chemical of interest, making it difficult to rule out other mechanisms of toxicity. To be a good candidate for an endocrine disruptor, effects should be observed in processes known to be under endocrine control, at life stages where endocrine signals are known to be active, and at concentrations below acute and chronic toxic effects. We developed a 96‐h reproductive assay using the freshwater rotifer Brachionus calyciflorus to screen for potential endocrine disruptors and examined cadmium, chlorpyrifos, naphthol, pentachlorophenol, estradiol, methoprene, precocene, nonylphenol, flutamide, and testosterone for effects on asexual and sexual reproduction. Flutamide, testosterone, and nonylphenol inhibited fertilization of sexual females at concentrations of 1, 10, and 50 μg/L, respectively. The fertilization no‐observable‐effect concentrations (NOECs) for these compounds were 5 to 200 times lower than previously described reproduction NOECs for B. calyciflorus. Sexual reproduction was inhibited with no effects on asexual reproduction, increasing the likelihood that these specific reproductive effects occurred through an endocrine mechanism. Rotifer reproduction assays may be a useful, rapid, and inexpensive method for screening compounds suspected to have endocrine disrupting activity in aquatic invertebrates.

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Molt‐independent growth inhibition of Daphnia magna by a vertebrate antiandrogen

Cited by 28 publications

References 33 publications

A Crab Is Not a Fish: Unique Aspects of the Crustacean Endocrine System and Considerations for Endocrine Toxicology

A Crab Is Not a Fish: Unique Aspects of the Crustacean Endocrine System and Considerations for Endocrine Toxicology

Metabolomic responses to sublethal contaminant exposure in neonate and adult Daphnia magna

Use of freshwater rotifer Brachionus calyciflorus in screening assay for potential endocrine disruptors

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