Mollusk allergy in shrimp-allergic patients: Still a complex diagnosis. An Italian real-life cross-sectional multicenter study

Scala, Enrico; Abeni, Damiano; Aruanno, Arianna; Boni, Elisa; Brusca, Ignazio; Cappiello, Francesco Liberato; Caprini, Elisabetta; Buzzulini, Francesca; Deleonardi, Gaia; Demonte, Antongiulio; Farioli, Laura; Rizzini, Fabio Lodi; Losappio, Laura; Macchia, Donatella; Manzotti, Giuseppina; Meneguzzi, Giorgia; Montagni, Marcello; Nucera, Eleonora; Onida, Rosa; Pastorello, Elide A.; Peveri, Silvia; Radice, Anna; Rivolta, Federica; Rizzi, A.; Giani, Mauro; Cecchi, Lorenzo; Pinter, Elena; Miglionico, Marzia; Vantaggio, Lorenzo; Pravettoni, Valerio; Villalta, Danilo; Asero, Riccardo

doi:10.1016/j.waojou.2022.100685

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…The major shrimp allergens among Hong Kong subjects were troponin C (Pen m 6) and glycogen phosphorylase (Pen m 14, 47.1%), tropomyosin (Pen m 1, 41.2%), and sarcoplasmic-calcium binding protein (Pen m 4, 35.3%), while those among Thai subjects were Pen m 1 (68.8%), Pen m 6 (50.0%), and fatty acidbinding protein (Pen m 13, 37.5%) [25]. In an Italian study conducted on individuals (aged 2-79 years) with a history of adverse reactions to shrimp, sensitization to Pen m 1 was predominant in the molecular sensitization profile; moreover, hypersensitivity to Pen m 1 was closely associated with an increased risk of a severe reaction to mollusks [26]. Shrimp tropomyosin (Pen m 1) is the leading IgE-binding protein in hypersensitivity to this allergen.…”

Section: Discussionmentioning

confidence: 99%

“…Protein profiles in shrimp with hypersensitivity may differ depending on the population, which is likely due to differences in genetics, environmental exposure, and dietary preferences. Therefore, it is important to determine the molecular profile for individual populations to ensure an optimal protein profile in shrimp allergy diagnostic tests [7,24,26,27].…”

Section: Discussionmentioning

confidence: 99%

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The Sensitization Profile for Selected Food Allergens in Polish Children Assessed with the Use of a Precision Allergy Molecular Diagnostic Technique

Knyziak-Mędrzycka,

Majsiak,

Gromek

et al. 2024

IJMS

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Individual populations show a variety of sensitization patterns, which may be associated with the geographic region, climate, dietary habits, or ways of preparing food. The purpose of this study was to comprehensively assess the food allergy sensitization profile in Polish children, particularly to eight food allergens (so-called “the Big 8”): cow milk, eggs, wheat, soybeans, fish, crustacean shellfish, tree nuts, and peanuts. To assess the prevalence and serum levels of specific immunoglobulins E (sIgE), we analyzed the results obtained from selected laboratories located in all regions of Poland that used the multiplex ALEX® test in the period from 2019 to 2022. Results from 3715 children were obtained. The mean age of the study population was 7.0 years. The results were stratified by age: <12 months (3.63%), 1–5 years (39.54%), 6–13 years (46.32%), and 14–18 years (10.0%). The final analysis included the sIgE results obtained with 95 food extracts and 77 food allergen molecules. The highest rates of sIgE to food allergen extracts were found for peanut (29.20%), hazel (28.20%), and apple (23.60%), and those to allergenic molecules were found for the PR-10 family of molecules (Cor a 1.0401 (23.77%), Mal d 1 (22.37%), Ara h 8 (16.93%), and globulin 7/8S (Ara h 1; 15.59%)). The lowest rates of sIgE reactivity to extracts were found for strawberry (0.40%), oregano (0.30%), and thornback ray (0.16%), and those to allergenic molecules were found for Mal d 2 (0.27%) (thaumatin-like protein, TLP), Ani s 1 (0.30%) (Kunitz-type serine protease inhibitor), and Che a 1 (0.43%) (Ole e 1 family). The rates of sensitization to storage proteins of the analyzed “the Big 8” molecules decreased significantly (p < 0.05) with age. Conversely, the rates of sensitization to PR-10 family proteins increased significantly with age. The three most common allergens in Poland, regardless of whether IgE was assayed against extracts or molecules of food allergens, were peanut, hazel, and apple (in different order depending on the ranking). A detailed analysis of sensitization to the extracts and molecules of main food allergens based on the results of a multiplex ALEX® test demonstrated the sensitization profile in Polish children (including molecular sensitization, particularly the “the Big 8” food allergen molecules), which shows considerable differences in comparison with those in other countries. Serum sIgE analysis of children from all regions of Poland revealed a food allergen molecular sensitization profile that changes with age.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Sensitization Profile for Selected Food Allergens in Polish Children Assessed with the Use of a Precision Allergy Molecular Diagnostic Technique

Knyziak-Mędrzycka,

Majsiak,

Gromek

et al. 2024

IJMS

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“…A noteworthy aspect of shellfish allergy is the diverse clinical expression between tolerance and intolerance to the consumption of mollusks (cephalopods and bivalves) in patients reactive to crustaceans. A recent multicentric cross-sectional Italian study [88 ▪ ] explored this aspect showing that the sensitization profile of patients with allergic reactions to both crustaceans and mollusks is dominated by sensitization to tropomyosin, arginine kinase, and SCP, compared with mollusk-tolerant patients. The study highlighted regional variations in sensitization, with higher mollusk reactivity in Central-Southern Italy.…”

Section: Models Of Molecular Allergologymentioning

confidence: 99%

What molecular allergy teaches us about genetics and epidemiology of allergies

Biagioni,

Scala,

Cecchi

2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review To delineate pertinent information regarding the application of molecular allergology within the realm of both genetic and epidemiological facets of allergic diseases. Recent findings The emergence of molecular allergy has facilitated the comprehension of the biochemical characteristics of allergens originating from diverse sources. It has allowed for the exploration of sensitization trajectories and provided novel insights into the influence of genetics and environmental exposure on the initiation and development of allergic diseases. This review delves into the primary discoveries related to the genetics and epidemiology of allergies, facilitated by the application of molecular allergy. It also scrutinizes the impact of environmental exposure across varied geoclimatic, socioeconomic, and lifestyle contexts. Additionally, the review introduces specific models of molecular allergy within the realms of plants and animals. Summary The utilization of molecular allergy in clinical practice holds crucially acknowledged diagnostic and therapeutic implications. From a research standpoint, there is a growing need for the widespread adoption of molecular diagnostic tools to achieve a more profound understanding of the epidemiology and natural progression of allergic diseases.

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“…In clinical practice, open OFCs are suitable for patients with consistent history. Although OFCs are usually performed to confirm or rule out the diagnosis of the culprit allergen, they may be performed to introduce a cross-reactive food in the children’s diet since a multicenter Italian study on adult and pediatric patients showed that the cross-reactivity between crustaceans and mollusks is not adequately predicted by the available diagnostic methods [ 117 ].…”

Section: Diagnosismentioning

confidence: 99%

IgE-Mediated Shellfish Allergy in Children

et al. 2023

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Shellfish, including various species of mollusks (e.g., mussels, clams, and oysters) and crustaceans (e.g., shrimp, prawn, lobster, and crab), have been a keystone of healthy dietary recommendations due to their valuable protein content. In parallel with their consumption, allergic reactions related to shellfish may be increasing. Adverse reactions to shellfish are classified into different groups: (1) Immunological reactions, including IgE and non-IgE allergic reactions; (2) non-immunological reactions, including toxic reactions and food intolerance. The IgE-mediated reactions occur within about two hours after ingestion of the shellfish and range from urticaria, angioedema, nausea, and vomiting to respiratory signs and symptoms such as bronchospasm, laryngeal oedema, and anaphylaxis. The most common allergenic proteins involved in IgE-mediated allergic reactions to shellfish include tropomyosin, arginine kinase, myosin light chain, sarcoplasmic calcium-binding protein, troponin c, and triosephosphate isomerase. Over the past decades, the knowledge gained on the identification of the molecular features of different shellfish allergens improved the diagnosis and the potential design of allergen immunotherapy for shellfish allergy. Unfortunately, immunotherapeutic studies and some diagnostic tools are still restricted in a research context and need to be validated before being implemented into clinical practice. However, they seem promising for improving management strategies for shellfish allergy. In this review, epidemiology, pathogenesis, clinical features, diagnosis, and management of shellfish allergies in children are presented. The cross-reactivity among different forms of shellfish and immunotherapeutic approaches, including unmodified allergens, hypoallergens, peptide-based, and DNA-based vaccines, are also addressed.

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Mollusk allergy in shrimp-allergic patients: Still a complex diagnosis. An Italian real-life cross-sectional multicenter study

Cited by 5 publications

References 21 publications

The Sensitization Profile for Selected Food Allergens in Polish Children Assessed with the Use of a Precision Allergy Molecular Diagnostic Technique

The Sensitization Profile for Selected Food Allergens in Polish Children Assessed with the Use of a Precision Allergy Molecular Diagnostic Technique

What molecular allergy teaches us about genetics and epidemiology of allergies

IgE-Mediated Shellfish Allergy in Children

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