Molluscum contagiosum of the cervix

Lang, Tee U.; Michelow, Pam; Khalbuss, Walid E.; Pantanowitz, Liron

doi:10.1002/dc.21699

Cited by 6 publications

(4 citation statements)

References 3 publications

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“…The patient's history of steroid treatment may also explain the lack of inflammation seen, although MCV typically does not incite a robust inflammatory response, unless the lesions Diagnostic Cytopathology DOI 10.1002/dc themselves rupture and become secondarily infected. 1,7 Furthermore, if we take into account the assertion that CA are proteins involved in acute inflammation, this may indeed be evidence of a cervical response to MCV infection.…”

Section: Discussionmentioning

confidence: 99%

Corpora amylacea and molluscum contagiosum on a cervical pap smear

Buckley

2016

Diagnostic Cytopathology

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When evaluating a Papanicolaou (Pap) smear, the cytology of the squamous epithelial cells is of utmost importance. This is what cytopathologists use to render a diagnosis, ranging from normal to atypical squamous cells of undetermined significance (ASCUS) to high grade squamous intraepithelial lesions, or even squamous cell carcinoma. However, occasionally the pathologist will run into microscopic noncellular material as in our case, such as corpora amylacea on the slides, or even uncommon viral inclusions such as Molluscum contagiosum (MCV). When these less common entities make their way on to a cervical Pap smear, it is important not only to correctly recognize them, but to understand their clinical implications as well. Diagn. Cytopathol. 2017;45:179-181. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Corpora amylacea and molluscum contagiosum on a cervical pap smear

Buckley

2016

Diagnostic Cytopathology

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“…Sexually transmitted molluscum contagiosum usually involves the anogenital area including the external genital organs, the inguinal folds, inner thighs or the suprapubic region 22 . Less frequently involved sites are the areola and nipple, 23–27 cervix, 28,29 oral mucosa, 30–34 palms and plantar surfaces of the foot 35,36 …”

Section: Clinical Findingsmentioning

confidence: 99%

2020 European guideline on the management of genital molluscum contagiosum

Edwards¹,

Boffa

Janier

et al. 2020

Acad Dermatol Venereol

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Molluscum contagiosum is a benign viral epidermal infection associated with high risk of transmission. The guideline is focused on the sexually transmitted molluscum contagiosum. The diagnosis is clinical with characteristic individual lesions, termed ‘mollusca’, seen as dome‐shaped, smooth‐surfaced, pearly, firm, skin‐coloured, pink, yellow or white papules, 2 ‐ 5 mm in diameter with central umbilication. Dermoscopy may facilitate diagnosis. Therapeutic options are numerous, including physical treatments (cautery, curettage and cryotherapy), topical chemical treatments (e.g. podophyllotoxin and imiquimod) or waiting for spontaneous resolution in immunocompetent patients. In pregnancy, it is safe to use physical procedures (e.g. cryotherapy). Immunosuppressed patients develop severe and recalcitrant molluscum lesions that may require treatment with cidofovir, imiquimod or interferon. Patients with molluscum contagiosum infection should be offered to be screened for other sexually transmitted infections.

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“…In adults, the virus may spread by sexual contact. [29–32] Infection follows close contact with an infected person or contaminated object, and results in an umbilicated, dome-shaped papule. Early lesions on the genitalia may be mistaken for herpes simplex or warts but, unlike herpes, these lesions are painless and the virus does not enter latency.…”

Section: Molluscum-like Bodiesmentioning

confidence: 99%

“…Although the diagnosis of MCV infection can be made based solely on the cytologic finding of molluscum bodies, electron microscopy and molecular techniques (eg, PCR) can be used to confirm the diagnosis. [29] In difficult cases, negative immunohistochemical staining for HSV and CMV can also help. As MCV is recognized as a sexually transmitted disease, specimens should be carefully screened for the presence of other sexually transmitted infections.…”

Section: Molluscum-like Bodiesmentioning

confidence: 99%

Cytomorphology of unusual infectious entities in the Pap test

et al. 2012

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Rare entities in the Pap test, including neoplastic and non-neoplastic conditions, pose challenges due to their infrequent occurrence in the daily practice of cytology. Furthermore, these conditions give rise to important diagnostic pitfalls. Infections such as tuberculosis cervicitis may be erroneously diagnosed as carcinoma, whereas others, such as schistosomiasis, are associated with squamous cell carcinoma. These cases include granuloma inguinale (donovanosis), tuberculosis, coccidioidomycosis, schistosomiasis, taeniasis, and molluscum contagiosum diagnosed in Pap tests. Granuloma inguinale shows histiocytes that contain intracytoplasmic bacteria (Donovan bodies). Tuberculosis is characterized by necrotizing granulomatous inflammation with Langhans-multinucleated giant cells. Coccidioidomycosis may show large intact or ruptured fungal spherules associated with endospores. Schistosoma haematobium is diagnosed by finding characteristic ova with a terminal spine. Molluscum contagiosum is characterized by the appearance of squamous cells with molluscum bodies. This article reviews the cytomorphology of selected rare infections and focuses on their cytomorphology, differential diagnosis, and role of ancillary diagnostic studies.

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Molluscum contagiosum of the cervix

Cited by 6 publications

References 3 publications

Corpora amylacea and molluscum contagiosum on a cervical pap smear

Corpora amylacea and molluscum contagiosum on a cervical pap smear

2020 European guideline on the management of genital molluscum contagiosum

Cytomorphology of unusual infectious entities in the Pap test

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