Molluscum contagiosum: its clinical, histopathologic, and immunohistochemical spectrum

Smith, Kathleen J.; COL, .; Usa, M.; Yeager, Josef; Cdr,; Usn, MC.; Skelton, Henry G.

doi:10.1046/j.1365-4362.1999.00677.x

Cited by 89 publications

(77 citation statements)

References 22 publications

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“…MCV genotype1 has been observed to be the predominant infection causing agent and represents 98% cases in the United States and 75-90% cases in general, while other genotypes are found to be more common in the immune compromised, HIV infected individuals and in countries outside the United States. 1,4,10,11 However, these genotypes are clinically indistinguishable. Usually they present as characteristic umbilicated flesh colored papules 3-5mm in size.…”

Section: Discussionmentioning

confidence: 99%

Molluscum contagiosum simulating a sebaceous cyst: a rare presentation

et al. 2016

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<p>Molluscum contagiosum (MC) is a viral infection of the skin and mucous membrane that usually presents as umbilicated, flesh colored dome shaped papules and are mostly self-limiting in immune competent individuals, though extensive lesions and atypical presentations may be observed in the immune-compromised. Here we present an extremely rare incidence of MC presenting as a sebaceous cyst (SC) in the post auricular region, in a fourteen year old immune-competent male child. Though few incidences of MC within an epidermal cyst (EC) have been reported, this infection primarily presenting as a cystic lesion simulating a SC in an immune competent individual is extremely rare. Imaging findings were consistent with subcutaneous cyst in keeping with a SC, which was then treated by surgical excision. Histopathology of the surgically removed lesion revealed a cyst lined by stratified squamous epithelium containing numerous molluscum bodies. No further treatment was required since this was the only intact lesion present. </p>

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Section: Discussionmentioning

confidence: 99%

Molluscum contagiosum simulating a sebaceous cyst: a rare presentation

et al. 2016

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“…These patients tend to form giant molluscum plaques and verrucous lesions. 1 Immunocompetent patients can form uncharacteristic lesions due to hair follicle involvement and variable states of inflammation, including secondary abscess formation.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of Atypical Molluscum Contagiosum: The Utility of a Squash Preparation

Eleftheriou

Kerr²,

Stratman³

2010

Clinical Medicine & Research

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A 4-year-old boy was referred to the outpatient dermatology clinic for two growths on his scalp. The first lesion had been present on the vertex scalp for six months and was asymptomatic except for recent inflammation and drainage of white exudate. A second growth developed on the patient's posterior parietal scalp in recent weeks and reportedly resembled the original appearance of the initial lesion. Review of systems was negative, and the parents denied any affected close contacts. There had been no intervention to the lesions. On examination, the vertex of the scalp revealed a 0.3 cm hemorrhagic crusted papule with surrounding desquamation and minimal surrounding erythema. The left posterior parietal scalp had a 0.2 cm

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“…18,23 This allows the virus to persist for months in the skin of infected individuals without signs of inflammation, and to efficiently escape elimination by CTLs. Our study suggests that MC159 FLIP contributes to the particularly efficient protection of the virus-infected host cell by multiple mechanisms, including the extended inhibition of both caspase-dependent and caspaseindependent Fas-induced cell death.…”

Section: Discussionmentioning

confidence: 99%

“…In immunosuppressed patients, the MCV lesions are often verrucous and bigger in size. 18,23 MCV encodes two FLIP homologues, called MC159 and MC160, which differ from herpesviral FLIP proteins by their unique C-terminal extensions of 66 and 202 amino acids, respectively. [24][25][26] The molecular functions of the two MCV FLIPs, and especially of their unusually long C-terminal extensions, are only partly understood.…”

Section: Introductionmentioning

confidence: 99%

The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosis

et al. 2006

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Members of the viral Flice/caspase-8 inhibitory protein (v-FLIP) family prevent induction of apoptosis by death receptors through inhibition of the processing and activation of procaspase-8 and -10 at the level of the receptor-associated death-inducing signaling complex (DISC). Here, we have addressed the molecular function of the v-FLIP member MC159 of the human molluscum contagiosum virus. MC159 FLIP powerfully inhibited both caspase-dependent and caspase-independent cell death induced by Fas. The Cterminal region of MC159 bound TNF receptor-associated factor (TRAF)3, was necessary for optimal TRAF2 binding, and mediated the recruitment of both TRAFs into the Fas DISC. TRAF-binding-deficient mutants of MC159 showed impaired inhibition of FasL-induced caspase-8 processing and Fas internalization, and had reduced antiapoptotic activity. Our findings provide evidence that a MC159/TRAF2/ TRAF3 complex regulates a new aspect of Fas signaling, and identify MC159 FLIP as a molecule that targets multiple features of Fas-induced cell death.

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Molluscum contagiosum: its clinical, histopathologic, and immunohistochemical spectrum

Cited by 89 publications

References 22 publications

Molluscum contagiosum simulating a sebaceous cyst: a rare presentation

Molluscum contagiosum simulating a sebaceous cyst: a rare presentation

Diagnosis of Atypical Molluscum Contagiosum: The Utility of a Squash Preparation

The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosis

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