Molluscum Contagiosum Eyelid Lesions as the Initial Manifestation of Acquired Immunodeficiency Syndrome

Leahey, Alan B.; Shane, John J.; Listhaus, Alan D.; Trachtman, Mark S.

doi:10.1016/s0002-9394(14)70791-3

Cited by 28 publications

(19 citation statements)

References 2 publications

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“…Molluscum contagiosum lesions of the eyelid have even been reported as the initial clinical manifestation of HIV disease 52,53. It is characterized by pink or pearly white wart-like nodules on the skin.…”

Section: Anterior Segment Lesions Due To Hiv Diseasementioning

confidence: 99%

Anterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome

Biswas¹,

Sudharshan²

2008

Indian J Ophthalmol

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Ocular complications are known to occur as a result of human immunodeficiency virus (HIV) disease. They can be severe leading to ocular morbidity and visual handicap. Cytomegalovirus (CMV) retinitis is the commonest ocular opportunistic infection seen in acquired immune deficiency syndrome (AIDS). Though posterior segment lesions can be more vision-threatening, there are varied anterior segment manifestations which can also lead to ocular morbidity and more so can affect the quality of life of a HIV-positive person. Effective antiretroviral therapy and improved prophylaxis and treatment of opportunistic infections have led to an increase in the survival of an individual afflicted with AIDS. This in turn has led to an increase in the prevalence of anterior segment and adnexal disorders. Common lesions include relatively benign conditions such as blepharitis and dry eye, to infections such as herpes zoster ophthalmicus and molluscum contagiosum and malignancies such as squamous cell carcinoma and Kaposi′s sarcoma. With the advent of highly active antiretroviral therapy, a new phenomenon known as immune recovery uveitis which presents with increased inflammation, has been noted to be on the rise. Several drugs used in the management of AIDS such as nevirapine or indinavir can themselves lead to severe inflammation in the anterior segment and adnexa of the eye. This article is a comprehensive update of the important anterior segment and adnexal manifestations in HIV-positive patients with special reference to their prevalence in the Indian population.

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Section: Anterior Segment Lesions Due To Hiv Diseasementioning

confidence: 99%

Anterior segment manifestations of human immunodeficiency virus/acquired immune deficiency syndrome

Biswas¹,

Sudharshan²

2008

Indian J Ophthalmol

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“…Widespread infection of the face with molluscum contagiosum is, however, common and highly characteristic of late HIV disease, with lesions persisting and responding poorly to treatment (6). Eyelid molluscum lesions may be the initial manifestation of AIDS (7). The prevalence of molluscum contagiosum in AIDS patients ranges from 5% to 18%, and is thought to be a clinical sign of marked HIV progression and very low CD4 cell counts (8).…”

Section: Discussionmentioning

confidence: 99%

Disseminated and Disfiguring Molluscum Contagiosum in a Child

Dave

Thappa

Karthikeyan

2003

Pediatric Dermatology

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We report widely disseminated and disfiguring lesions of molluscum contagiosum occurring in a 4-year-old girl secondary to a primary immunodeficiency disorder. The child, born of consanguineous parents, had multiple, asymptomatic, raised, skin-colored and whitish lesions since 2 years of age. On physical examination she had growth retardation features with grade II protein energy malnutrition. Cutaneous examination revealed numerous, widespread, skin-colored to translucent, firm, umbilicated papules of varying sizes (pinpoint to larger than 10 mm). They were distributed bilaterally over all four limbs, including the dorsum of the hands and feet, trunk, face (including lips), eyelids, auriculae, and perineal and gluteal areas. In places, they were linearly disposed and had coalesced to form plaques. A biopsy specimen from a representative skin lesion (arm) demonstrated lobulated epidermal growth consisting of keratinocytes with large intracytoplasmic eosinophilic inclusion bodies and a central crater. These findings were consistent with the diagnosis of molluscum contagiosum. Topical therapies with phenol and trichloroacetic acid were ineffective The child succumbed to a fulminant systemic infection at home, 2 months after discharge from the hospital. The extent and distribution of molluscum contagiosum in our patient was remarkably vivid and has been hitherto reported only rarely.

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“…Mollusca contagiosa der Augenlider treten nicht selten als Primärmanifestation im Stadium Aids auf [7]. Die Anwendung hochpotenter, topischer Kortikosteroide kann bei Patienten mit atopischem Ekzem zur Entwicklung von Hunderten von Mollusca contagiosa beitragen (Eczema molluscatum).…”

Section: Diskussionunclassified