Molluscum Contagiosum

Schaffer, Julie V.; Berger, Emily

doi:10.1001/jamadermatol.2016.2367

Cited by 27 publications

(21 citation statements)

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“…Molluscum contagiosum is a viral infection that affects the skin and is caused by the dermatotropic poxvirus molluscum contagiosum virus (MCV) [237,238]. Unlike smallpox and human monkeypox diseases, MCV is nonlethal, mostly common in children and young adults and present worldwide [237,238]. However, MCV causes severe skin infections in immunosuppressed adults [237,238].…”

Section: Selenoproteins In Viral Genomesmentioning

confidence: 99%

“…Unlike smallpox and human monkeypox diseases, MCV is nonlethal, mostly common in children and young adults and present worldwide [237,238]. However, MCV causes severe skin infections in immunosuppressed adults [237,238]. A typical feature is the apparition of single or multiple papules on the skin, which may persist for a few years.…”

Section: Selenoproteins In Viral Genomesmentioning

confidence: 99%

“…A typical feature is the apparition of single or multiple papules on the skin, which may persist for a few years. Most cases resolve in six to nine months without specific treatments [237,238]. Such a prolonged infection implies that MCV successfully manipulates the host environment.…”

Section: Selenoproteins In Viral Genomesmentioning

confidence: 99%

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Selenium, Selenoproteins and Viral Infection

et al. 2019

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Reactive oxygen species (ROS) are frequently produced during viral infections. Generation of these ROS can be both beneficial and detrimental for many cellular functions. When overwhelming the antioxidant defense system, the excess of ROS induces oxidative stress. Viral infections lead to diseases characterized by a broad spectrum of clinical symptoms, with oxidative stress being one of their hallmarks. In many cases, ROS can, in turn, enhance viral replication leading to an amplification loop. Another important parameter for viral replication and pathogenicity is the nutritional status of the host. Viral infection simultaneously increases the demand for micronutrients and causes their loss, which leads to a deficiency that can be compensated by micronutrient supplementation. Among the nutrients implicated in viral infection, selenium (Se) has an important role in antioxidant defense, redox signaling and redox homeostasis. Most of biological activities of selenium is performed through its incorporation as a rare amino acid selenocysteine in the essential family of selenoproteins. Selenium deficiency, which is the main regulator of selenoprotein expression, has been associated with the pathogenicity of several viruses. In addition, several selenoprotein members, including glutathione peroxidases (GPX), thioredoxin reductases (TXNRD) seemed important in different models of viral replication. Finally, the formal identification of viral selenoproteins in the genome of molluscum contagiosum and fowlpox viruses demonstrated the importance of selenoproteins in viral cycle.

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Section: Selenoproteins In Viral Genomesmentioning

confidence: 99%

Section: Selenoproteins In Viral Genomesmentioning

confidence: 99%

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Selenium, Selenoproteins and Viral Infection

et al. 2019

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“…In immunocompetent patients, molluscum contagiosum can last for an average of one year and resolve spontaneously 3. Treatments include curettage, cryotherapy, and electrodesiccation but may risk scarring 4. Encourage patients to avoid autoinoculation and transmission to close contacts.…”

Section: Answermentioning

confidence: 99%

Umbilicated papules on the face

Qian

2019

BMJ

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“…An eczema type reaction, entitled molluscum dermatitis, consisting of erythema, scales and inflamed lesions may appear secondary to a local immune response, and this leads to clinical resolution 56 . In contrast, the appearance of molluscum contagiosum in the setting of atopic dermatitis (eczema molluscatum) may represent a clinical challenge, producing disseminated, inflammatory lesions, covered by scales or haemorrhagic crusts and associated with pruritus 57,58 …”

Section: Clinical Findingsmentioning

confidence: 99%

2020 European guideline on the management of genital molluscum contagiosum

Edwards¹,

Boffa

Janier

et al. 2020

Acad Dermatol Venereol

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Molluscum contagiosum is a benign viral epidermal infection associated with high risk of transmission. The guideline is focused on the sexually transmitted molluscum contagiosum. The diagnosis is clinical with characteristic individual lesions, termed ‘mollusca’, seen as dome‐shaped, smooth‐surfaced, pearly, firm, skin‐coloured, pink, yellow or white papules, 2 ‐ 5 mm in diameter with central umbilication. Dermoscopy may facilitate diagnosis. Therapeutic options are numerous, including physical treatments (cautery, curettage and cryotherapy), topical chemical treatments (e.g. podophyllotoxin and imiquimod) or waiting for spontaneous resolution in immunocompetent patients. In pregnancy, it is safe to use physical procedures (e.g. cryotherapy). Immunosuppressed patients develop severe and recalcitrant molluscum lesions that may require treatment with cidofovir, imiquimod or interferon. Patients with molluscum contagiosum infection should be offered to be screened for other sexually transmitted infections.

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Molluscum Contagiosum

Abstract: Molluscum contagiosum is a common viral infection that causes small bumps on the skin.

Cited by 27 publications

References 0 publications

Selenium, Selenoproteins and Viral Infection

Selenium, Selenoproteins and Viral Infection

Umbilicated papules on the face

2020 European guideline on the management of genital molluscum contagiosum

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