Molluscicidal activity of some Brazilian<i>Solanum</i>spp. (Solanaceae) against<i>Biomphalaria glabrata</i>

Silva, T. M. S.; Batista, M. M.; Câmara, Celso A.; Agra, María F.

doi:10.1179/136485905x36208

Cited by 49 publications

(36 citation statements)

References 26 publications

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“…Earlier it has been reported that organic (ether, chloroform and ethanol) extracts of B. variegata and M. elengi leaf and bark contain tannin, saponin, glycoside, terpenoids, flavonoids etc. 5,6,8,19,25 . Although large numbers Column purification: One hundred milliliters of B. variegata leaf ethanol extract and M. elengie bark ethanol extract were subjected to silica gel (60-120 mesh, Qualigens glass, Precious Electro Chemindus Private Limited, Mumbai, India) chromatography through 95×45cm column.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the molluscicidal activity of Bauhinia variegata and Mimusops elengi plant extracts against the fasciola vector lymnaea acuminata

Singh

2012

Rev. Inst. Med. trop. S. Paulo

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Section: Introductionmentioning

confidence: 99%

Characterization of the molluscicidal activity of Bauhinia variegata and Mimusops elengi plant extracts against the fasciola vector lymnaea acuminata

Singh

2012

Rev. Inst. Med. trop. S. Paulo

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“…The signifi cant correlation between the brine shrimp assay and in vitro growth inhibition of human solid tumor cell lines demonstrated by the National Cancer Institute (NCI, USA) is signifi cant because it shows the value of this bioassay as a pre-screening tool for antitumor drug research (Anderson et al, 1991). The wide distribution, anticancer properties (Kupchan et al, 1965;Cham et al, 1987;Cham, 1994;Daunter;Cham, 1990;Hu et al, 1999;Esteves-Souza et al, 2002;Lee et al, 2004;Friedman et al, 2005) of the glycoalkaloids and molluscicidal activity (Silva et al, 2005c) of the crude extracts, led us to the selection of these Solanum species for the present work.…”

Section: Introductionmentioning

confidence: 99%

Brine shrimp bioassay of some species of Solanum from Northestern Brazil

Silva¹,

Nascimento²,

Batista³

et al. 2007

Rev. bras. farmacogn.

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RESUMO: "Bioatividade em Artemia salina de várias espécies de Solanum do Nordeste Brasileiro". Os extratos metanólicos de 13 espécies de Solanum (Solanaceae) foram testados para verififi cação da bioatividade em Artemia salina. As espécies testadas (partes aéreas, raízes e frutos) foram: S. asperum, S. capsicoides, S. palinacantum, S. paludosum, S. paniculatum, S. paraibanum, S. sisymbriifolium, S. crinitum, S. diamantinense, S. megalonyx, S. torvum, S. asterophorum e S. stipulaceum. Das treze espécies testadas, quatro foram inativas. Os extratos dos frutos de S. asperum (CL 50 = 420,5 µg/mL) e S. paludosum (CL 50 = 548,0 µg/mL), partes aéreas de S. diamantinense (CL 50 = 481,0 µg/mL) e S. sisymbrifolium (CL 50 = 382,7 µg/mL), e das raízes S. asperum (CL 50 = 593,4 µg/mL) e S. stipulaceum (CL 50 = 823,1 µg/mL) que mostraram atividade moluscicida contra Biomphalaria glabrata também mostraram atividade tóxica em Artemia salina.Unitermos: Solanaceae, Solanum, Artemia salina, bioatividade. ABSTRACT:The methanolic extracts of 13 Specieis of the genus Solanum (Solanaceae) have been tested for bioactivity in Artemia salina. The extracts investigated were prepared from various parts (aerial parts, roots and fruits) of S. asperum, S. capsicoides, S. palinacantum, S. paludosum, S. paniculatum, S. paraibanum, S. sisymbriifolium, S. crinitum, S. diamantinense, S. megalonyx, S. torvum, S. asterophorum and S. stipulaceum. The lethal concentrations were determined for the extracts and among thirteen plants tested, four appear to be inactive. The extracts of the fruits of S. asperum (LC 50 = 420.5 µg/mL) and S. paludosum (LC 50 = 548.0 µg/mL), aerial parts of S. diamantinense (LC 50 = 481.0 µg/mL) and S. sisymbrifolium (LC 50 = 382.7 µg/mL), and the roots of S. asperum (LC 50 = 593.4 µg/mL) and S. stipulaceum (LC 50 = 823.1 µg/mL), all of which previously showed molluscicidal activity against Biomphalaria glabrata were also found to be active in the present study with brine shrimp.

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“…A atividade moluscicida contra Biomphalaria glabrata foi estudada por Silva et al (2005) utilizando-se o extrato metanólico das raízes e por , testando o extrato alcaloídico de ramos e caule. Os estudos identificaram que tanto o extrato do caule como o da raiz apresentou bioatividade no controle da esquistossomose (CL50 = 45,2 μg/mL e CL50 = 48,49μg/mL, respectivamente).…”

Section: Resultsunclassified

A etnobotânica aplicada à úlcera gástrica e avaliação farmacológica de Solanum stipulaceum

et al. 2017

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ResumoO saber popular sobre plantas medicinais tem auxiliado estratégias de bioprospecção de espécies e direcionado o estudo para a descoberta de novas atividades farmacológicas. O objetivo desta pesquisa foi identificar espécies medicinais utilizadas contra úlcera gástrica pela comunidade do Povoado Vila Capim, Arapiraca, Alagoas e, avaliar a atividade antiulcerogênica gástrica da espécie mais saliente. Para a seleção dos informantes-chave utilizou-se a técnica da bola de neve e aplicadas entrevistas semiestruturadas. A análise das falas foi pela técnica do Discurso do Sujeito Coletivo. Para os testes farmacológicos foram utilizados ratos Wistar machos no modelo de lesão gástrica aguda induzida por etanol absoluto. A toxicidade aguda foi avaliada. Dezessete informantes-chave indicaram os sintomas e plantas medicinais utilizadas contra a úlcera gástrica. A espécie com maior valor de saliência foi a Solanum stipulaceum (sacatinga), escolhida para testes químicos e farmacológicos. O extrato aquoso bruto (SSaq) apresentou atividade significativa na dose de 200 mg kg -1 (p<0,05), sendo capaz de inibir lesões (91,35%). O extrato etanólico (SSet) demonstrou atividade gastroprotetora nas doses de 200 e 400 mg kg -1 (p<0.01), com inibição de 71,12% e 76,38%, respectivamente. É necessário aprofundar os estudos para a elucidação dos compostos químicos das folhas da espécie, toxicologia e identificação dos mecanismos de ação subjacentes à atividade gastroprotetora de S. stipulaceum.Palavras-chave: Plantas medicinais, bioprospecção, análise de saliência, ensaios in vivo. Applied ethnobotany to gastric ulcer and pharmacological evaluation of Solanum stipulaceum AbstractThe popular knowledge about medicinal plants has helped the bioprospecting strategies of species and directed to a discovery of new pharmacological activities. The aim of this study was to identify medicinal species used against gastric ulcer in the Vila Capim village, Arapiraca, Alagoas, and it evaluating a gastric anti -inflammatory activity of the most salient species. For a selection of key informants has used a snowball technique. The TCLE was signed and semi-structured interviews were applied. The analysis of the speeches was done on the Discourse of the Collective Subject technique. For pharmacological experimental tests, plant extract was underwent the Acute Gastric Lesion Model induced by absolute ethanol and using Wistar male rats. Acute toxicity was evaluated. Seventeen key informants indicated the symptoms and the medicinal plants used against gastric ulcer. The species with the highest salience value was Solanum stipulaceum Roem & Schult (sacatinga), chosen for chemical and pharmacological tests. The crude aqueous extract (SSaq) presented significant activity at a dose of 200 mg kg -1 (p<0.05), being able to inhibit lesions (91.35%). Ethanolic extract (SSet) showed gastroprotective activity at doses of 200 and 400 mg kg -1 (p <0.01), with inhibition of (71.12% and 76.38%), respectively. Further studies will be need for analysis of toxicit y and id...

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Molluscicidal activity of some BrazilianSolanumspp. (Solanaceae) againstBiomphalaria glabrata

Cited by 49 publications

References 26 publications

Characterization of the molluscicidal activity of Bauhinia variegata and Mimusops elengi plant extracts against the fasciola vector lymnaea acuminata

Characterization of the molluscicidal activity of Bauhinia variegata and Mimusops elengi plant extracts against the fasciola vector lymnaea acuminata

Brine shrimp bioassay of some species of Solanum from Northestern Brazil

A etnobotânica aplicada à úlcera gástrica e avaliação farmacológica de Solanum stipulaceum

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