Molluscicidal activity of polyvinylpyrrolidone (PVP)-functionalized silver nanoparticles to Biomphalaria glabrata: Implications for control of intermediate host snail of Schistosoma mansoni

Araújo, Paula Sampaio; Caixeta, Maxwell Batista; Brito, Rafaella da Silva; Gonçalves, Bruno Bastos; Silva, Sueli Maria da; Lima, E.C.D.; Silva, Luciana Damacena; Bezerra, José Clecildo Barreto; Rocha, Thiago Lopes

doi:10.1016/j.actatropica.2020.105644

Cited by 21 publications

(6 citation statements)

References 35 publications

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“…Molluscicides capable of morphological changes in embryos are important as it can make the snail's hatching capacity unfeasible or reduce its reproductive capacity, consequently reducing the mollusc population and transmission risks of S. mansoni. 21,42 Embryos with developmental delays, malformed and hydropic were also the alterations found in the study by Santos et al, similar to our results. 21 Embryos with nonspecific malformations can be classified as teratomorphic, such as exogastrulation, or hydropic embryos.…”

Section: Discussionsupporting

confidence: 93%

Toxic, cytotoxic and genotoxic effect of plumbagin in the developmental stages of Biomphalaria glabrata (Say, 1818‐intermediate host) and cercaricidal activity against the infectious agent of schistosomiasis mansoni

França

Silva

Diniz

et al. 2022

Pest Management Science

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BACKGROUND: Snails of the genus Biomphalaria are intermediate hosts of Schistosoma mansoni, the main etiological agent of schistosomiasis mansoni, which affects about 236.6 million people in tropical and subtropical regions of the world. The World Health Organization recommends the population control of vector snails as one of the strategies to reduce the prevalence and incidence of schistosomiasis. In this study, molluscicidal and antiparasitic activities of plumbagin, a naturally sourced naphthoquinone with a range of biological effects, were evaluated against B. glabrata and cercariae of S. mansoni. RESULTS:After 24 h of exposure, plumbagin demonstrated molluscicidal activity at low concentrations against embryos (LC 50 of 0.56, 0.93, 0.68, 0.51 and 0.74 ∼g mL −1 for the blastula, gastrula, trochophore, veliger and hippo stage, respectively) and adult snails (LC 50 of 3.56 ∼g mL −1 ). There were no changes in exposed snails' fecundity or fertility; however, plumbagin was able to increase the frequency of DNA damage and the number of hemocytes, with apoptosis and binucleation being the main hemocyte alterations. In addition, plumbagin showed death of S. mansoni cercariae in the concentration of 1.5 ∼g mL −1 in 60 min, while showing moderate toxicity to Artemia salina.CONCLUSION: Plumbagin proved to be a promising substance for the control of B. glabrata population, intermediate host of S. mansoni, as well as the cercariae, infective stage for humans (definitive host), while being moderately toxic to A. salina, a crustacean widely used in ecotoxicity tests.

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Section: Discussionsupporting

confidence: 93%

Toxic, cytotoxic and genotoxic effect of plumbagin in the developmental stages of Biomphalaria glabrata (Say, 1818‐intermediate host) and cercaricidal activity against the infectious agent of schistosomiasis mansoni

França

Silva

Diniz

et al. 2022

Pest Management Science

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“…The freshwater snails Biomphalaria spp. have been one of the widely used invertebrate model system in laboratories [8][9][10][11][12][13][14][15][16], mainly due to their short life cycle, ease of maintenance and reproduction [9,10]. A lot of research has used the snail as a biomonitor in ecotoxicological risk assessments due to its high sensibility to several aquatic pollutants [8,[11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

New Insights into the Gametogenesis of Biomphalaria glabrata (Mollusca, Gastropoda, Pulmonata): Implications for Histopathological Assessment

Rodrigues

Caixeta

Rocha

2021

Braz. arch. biol. technol.

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The reproductive system has a fundamental role in population dynamics and several reproduction strategies have been shaped by the environment over time. Many environmental pressures are generated by releasing pollutants, as endocrine disruptors, that can affect the reproductive system of individuals, among them invertebrates. The freshwater snails Biomphalaria spp. are used as biomonitor in several ecotoxicological studies; however, there are few studies about gametogenesis and morphology of reproductive snail cells, which could be used as a new biomarker. In this sense, the current study aims to characterize Biomphalaria glabrata gametogenesis, bringing new histomorphometric parameters for germinative cells. Results showed that the hermaphrodite tissue is formed by several acini with simple pavement epithelium with germinative and somatic cells. Oogenesis was classified into five developmental stages (OI to OV) according to diameter, nucleus area, total area, and follicular cell development, and then classified into previtellogenic and vitellogenic oocytes. The spermatogenesis was classified into spermatogonia (Spg), spermatocytes (Spc) and spermatids that were subdivided into five stages (Spt I to Spt V) according to cytoplasm losing, and nucleus spiralization along with Sertoli cells development. Thus, the HIGHLIGHTS  The gametogenesis of Biomphalaria glabrata was described. Oogenesis was classified into five developmental stages. New histomorphometric parameters were described for oocytes. Spermatogenesis was classified into seven stages of development. B. glabrata histomorphometric parameters as a tool for environmental and public health researches.2 Rodrigues, C.C.; et al.

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“…Authors described that due to embryos are surrounded by different membranes and substances they were protected against the pesticide. In concordance, low bioavailability and toxicity of silver nanoparticles ( Araújo et al, 2020 ) and ivermectin ( Katz et al, 2017 ) to B. glabrata embryos were associated with the protective role of the gelatinous membrane ( Caixeta et al, 2022 ). B. straminea snails exposed to water from Lugano Lake laid egg masses with morphological changes including eggs with abnormal forms such as non-round eggs, overlapping eggs and eggs with arrested development at different stages.…”

Section: Discussionmentioning

confidence: 93%

Aquatic Contamination in Lugano Lake (Lugano Lake Ecological Reserve, Buenos Aires, Argentina) Cause Negative Effects on the Reproduction and Juvenile Survival of the Native Gastropod Biomphalaria straminea

et al. 2022

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Lugano Lake is located in an Ecological Reserve of Buenos Aires City. Biomonitoring of its water quality is essential due to its importance as a place for recreation and protection of native species. Biomphalaria straminea is a native hermaphrodite aquatic gastropod that inhabits different freshwater bodies of Argentina and was recently selected as a potential bioindicator. We propose this study as a first approach to assessing specific organisms’ use in biomonitoring of urban wild reserves, and the usefulness of reproduction assays. B. straminea survival, behavior, reproduction success and offspring survival after the exposure to water samples from Lugano Lake (L1, L2, and L3) were evaluated. Temperature, pH, conductivity and dissolved oxygen were registered in situ. Samples were transported to the laboratory and chemical analysis and bioassays were performed using 20 snails per site. A control group with tap water was added. Egg masses were separated, exposed individually and observed daily using a stereoscopic microscope. After hatching, juveniles were placed in tap water and offspring survival was registered at the first, second, third and fourth months after the beginning of the assay. High levels of conductivity, turbidity and nutrients were obtained. Ammonium and nitrite were higher than the guideline level for the protection of aquatic life. During the bioassay 20% of the snails (L2 and L3) showed abnormally protruding of the head-food region. The number of eggs and embryonated eggs per mass did not differ between treatments. Egg masses exposed to water samples from the lake presented overlapping and abnormal eggs and arrested embryos. Besides, low % of hatching (L1: 33%, L2: 42%, and L3: 16%) and juvenile survival after the first (L1:14%; L2:78%) and second month (L1: 60%) were noted. In the control group, 85% of hatching and 100%–90% of survival were observed. Our results suggests the presence of pollutant in the lake. B. straminea seems to be a sensitive local species. Biomphalaria spp. reproduction assays can provide a valuable endpoint for toxicity and risk assessments and a usefulness tool for biomonitoring water quality.

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Molluscicidal activity of polyvinylpyrrolidone (PVP)-functionalized silver nanoparticles to Biomphalaria glabrata: Implications for control of intermediate host snail of Schistosoma mansoni

Cited by 21 publications

References 35 publications

Toxic, cytotoxic and genotoxic effect of plumbagin in the developmental stages of Biomphalaria glabrata (Say, 1818‐intermediate host) and cercaricidal activity against the infectious agent of schistosomiasis mansoni

Toxic, cytotoxic and genotoxic effect of plumbagin in the developmental stages of Biomphalaria glabrata (Say, 1818‐intermediate host) and cercaricidal activity against the infectious agent of schistosomiasis mansoni

New Insights into the Gametogenesis of Biomphalaria glabrata (Mollusca, Gastropoda, Pulmonata): Implications for Histopathological Assessment

Aquatic Contamination in Lugano Lake (Lugano Lake Ecological Reserve, Buenos Aires, Argentina) Cause Negative Effects on the Reproduction and Juvenile Survival of the Native Gastropod Biomphalaria straminea

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