Molluscicidal activity of cardiac glycosides isolated from <scp><i>Adenium obesum</i></scp>

Alzabib, Ali A.; Abobakr, Yasser; Al‐Sarar, Ali S.; Hussein, Heba A.; Basudan, Omer A.; El‐Gamal, Ali A.; Abdel-Kader, Maged S.; El_Komy, Mahmoud H.

doi:10.1002/ps.5388

Cited by 5 publications

(5 citation statements)

References 35 publications

(50 reference statements)

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“…The two molluscicidal active cardiac glycosides, cerberin 169 and neriifolin 170 (Table 1 ), were isolated from the stems of Adenium obesum (Alzabib et al 2019 ). Products 169 and 170 had significant molluscicidal activity against Monacha obstructa snails with LC 50 values of 5.39 and 4.30 ppm in 24 h, respectively.…”

Section: Development Of Plant Molluscicidesmentioning

confidence: 99%

Molluscicides against the snail-intermediate host of Schistosoma: a review

et al. 2021

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Schistosomiasis, a neglected tropical disease (NTD), is one of the most prevalent parasitoses in the World. Certain freshwater snail species are the intermediate host in the life cycle of schistosome species. Controlling snails employing molluscicides is an effective, quick, and convenient intervention strategy to prevent the spread of Schistosoma species in endemic regions. Advances have been made in developing both synthetic molluscicides and molluscicides derived from plants. However, at present, the development of molluscicides is not adapted to the actual demand for snails and schistosoma controlling. We undertake a systematic review of exploitation and application of synthetic molluscicides and molluscicides derived from plants to combat intermediate host snails. The detailed molluscicidal activity, structure–activity relationship, structural feature, and possible mechanism of some molluscicides are also highlighted, which may afford an important reference for the design of new, more effective molluscicides with low environmental impact and realize the aim of controlling schistosome at transmission stages. Supplementary Information The online version contains supplementary material available at 10.1007/s00436-021-07288-4.

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Section: Development Of Plant Molluscicidesmentioning

confidence: 99%

Molluscicides against the snail-intermediate host of Schistosoma: a review

et al. 2021

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“…Insecticidal effects of glycosides have been reported by several researchers [63][64][65][66][67][68][69].…”

Section: Glycosidesmentioning

confidence: 99%

Phytochemical Analysis and Efficacy Of Rosemary (Rosmarinus Officinalis) and Mint (Mentha Spicata) Extracts Against Fall Armyworm (Spodoptera Frugiperda) on Baby Corn (Zea Mays)

Kalinda

Rioba

2020

Acta Chemica Malaysia

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AbstractFall armyworm (Spodoptera frugiperda, J.E. Smith) is a pest with devasting effects on maize. A laboratory biassay was conducted to analyse the phytochemicals and determine the efficacy of M. spicata and R. officinalis extracts on FAW. Treatments were laid out in a Completely Randomized Design (CRD) with 3 replications. The factors included solvent [Methanol (Me), dichloromethane (DCM), distilled water (Di)] and the plant species (M. spicata and R. officinalis). Coragen SC 200 (Co) and Distilled water (Di) were the positive and negative controls, respectively. FAW rearing, plant extract preparation and phytochemical screening were done using standard procedure. Data collection and analysis was done using standard procedures. The extract yield was highest for R. officinalis regardless of the solvent used. Me-R. officinalis and Di-M. spicata extracts yielded the highest. Saponins, glycosides, alkaloid, flavonoids and tannins. Flavonoid contents were 7.9036 mg/mL and 6.0073 ± 0.6117 mg/mL in methanolic extract of M. spicata and R. officinalis, respectively. M. spicatha and R. officinalis extracts caused 100% mortality to 3rd instar larvae. Based on the findings, both M. spicata and R. officinalis have several secondary metabolites that confer insecticidal activity of the plants against FAW, hence should be evaluated under field conditions.

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“…[11][12][13] Thus, the scientific community recommends the search for new molluscicide candidates, of natural or synthetic origin, which are biosafe, stable, have selective action, considered cost-effective in production and application, and that have action against snails in embryonic and adult stages. [14][15][16] Among several natural secondary metabolites produced by plants used in traditional medicine and pharmaceutical industries, naphthoquinones, a class of naphthalene derivatives, have a broad pharmacological and biological spectrum. 17,18 Studies have reported the action of naphthoquinones against immature stages and adults of S. mansoni and S. haematobium, and toxicity against embryos and adults of the species B. alexandrina, B. glabrata and Bulinus truncatus, vectors of medical importance.…”

Section: Introductionmentioning

confidence: 99%

Toxic, cytotoxic and genotoxic effect of plumbagin in the developmental stages of Biomphalaria glabrata (Say, 1818‐intermediate host) and cercaricidal activity against the infectious agent of schistosomiasis mansoni

França

Silva

Diniz

et al. 2022

Pest Management Science

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BACKGROUND: Snails of the genus Biomphalaria are intermediate hosts of Schistosoma mansoni, the main etiological agent of schistosomiasis mansoni, which affects about 236.6 million people in tropical and subtropical regions of the world. The World Health Organization recommends the population control of vector snails as one of the strategies to reduce the prevalence and incidence of schistosomiasis. In this study, molluscicidal and antiparasitic activities of plumbagin, a naturally sourced naphthoquinone with a range of biological effects, were evaluated against B. glabrata and cercariae of S. mansoni. RESULTS:After 24 h of exposure, plumbagin demonstrated molluscicidal activity at low concentrations against embryos (LC 50 of 0.56, 0.93, 0.68, 0.51 and 0.74 ∼g mL −1 for the blastula, gastrula, trochophore, veliger and hippo stage, respectively) and adult snails (LC 50 of 3.56 ∼g mL −1 ). There were no changes in exposed snails' fecundity or fertility; however, plumbagin was able to increase the frequency of DNA damage and the number of hemocytes, with apoptosis and binucleation being the main hemocyte alterations. In addition, plumbagin showed death of S. mansoni cercariae in the concentration of 1.5 ∼g mL −1 in 60 min, while showing moderate toxicity to Artemia salina.CONCLUSION: Plumbagin proved to be a promising substance for the control of B. glabrata population, intermediate host of S. mansoni, as well as the cercariae, infective stage for humans (definitive host), while being moderately toxic to A. salina, a crustacean widely used in ecotoxicity tests.

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Molluscicidal activity of cardiac glycosides isolated from Adenium obesum

Cited by 5 publications

References 35 publications

Molluscicides against the snail-intermediate host of Schistosoma: a review

Molluscicides against the snail-intermediate host of Schistosoma: a review

Phytochemical Analysis and Efficacy Of Rosemary (Rosmarinus Officinalis) and Mint (Mentha Spicata) Extracts Against Fall Armyworm (Spodoptera Frugiperda) on Baby Corn (Zea Mays)

Toxic, cytotoxic and genotoxic effect of plumbagin in the developmental stages of Biomphalaria glabrata (Say, 1818‐intermediate host) and cercaricidal activity against the infectious agent of schistosomiasis mansoni

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